Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

387

Name

RHOA

Synonymous

ARH12|ARHA|RHO12|RHOH12;ras homolog family member A;RHOA;ras homolog family member A

Definition

Aplysia ras-related homolog 12|h12|oncogene RHO H12|ras homolog gene family, member A|rho cDNA clone 12|small GTP binding protein RhoA|transforming protein RhoA

Position

3p21.3

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr3:49396578-49450431chr3:49396751-49396751rs3448Single_Nucleotides|eQTL|APEH, Single_Nucleotides|eQTL|P4HTM, Motifs|Footprinting|Hand1:E47, Motifs|Footprinting|Hand1:E47, Motifs|Footprinting|Hand1:E47, Motifs|Footprinting|Hand1:E47, Motifs|Footprinting|Hand1:E47, Motifs|Footprinting|Hand1:E47, Motifs|PWM|Hand1:E47, Motifs|Footprinting|RP58, Motifs|Footprinting|RP58, Motifs|PWM|RP58, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|FAIRE|Helas3, Protein_Binding|ChIP-seq|ERG
chr3:49396578-49450431chr3:49411404-49411404rs7621003Single_Nucleotides|eQTL|QARS, Single_Nucleotides|eQTL|WDR6, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Monocd14
chr3:49396578-49450431chr3:49423976-49423976rs6797765Single_Nucleotides|eQTL|QARS, Single_Nucleotides|eQTL|WDR6, Motifs|Footprinting|C/EBP, Motifs|Footprinting|C/EBP, Motifs|Footprinting|C/EBP, Motifs|PWM|C/EBP, Motifs|Footprinting|C/EBP, Motifs|Footprinting|C/EBP, Motifs|Footprinting|C/EBP, Motifs|PWM|C/EBP, Motifs|Footprinting|, Chromatin_Structure|FAIRE|Hepg2, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|DNase-seq|Hcpe, Protein_Binding|ChIP-seq|CEBPB
chr3:49396578-49450431chr3:49439440-49439440rs2140270Single_Nucleotides|eQTL|APEH, Single_Nucleotides|eQTL|P4HTM, Chromatin_Structure|DNase-seq|Hl60
chr3:49396578-49450431chr3:49439725-49439725rs2177268Single_Nucleotides|eQTL|AMT, Motifs|PWM|FOXP1, Motifs|PWM|Sox12, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Lncap
chr3:49396578-49450431chr3:49443081-49443081rs13096474Single_Nucleotides|eQTL|APEH, Single_Nucleotides|eQTL|P4HTM, Single_Nucleotides|eQTL|AMT, Single_Nucleotides|eQTL|NCKIPSD, Single_Nucleotides|eQTL|NICN1, Single_Nucleotides|eQTL|WDR6, Chromatin_Structure|DNase-seq|Hasp
chr3:49396578-49450431chr3:49449638-49449638rs940045Single_Nucleotides|eQTL|APEH, Single_Nucleotides|eQTL|P4HTM, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Cll, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|Gm19240, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Gm18507, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Panislets, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Medullo, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|FAIRE|Htr8, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|FAIRE|Gm18507, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|FAIRE|Gm12891, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Jurkat, Chromatin_Structure|FAIRE|Gm19239, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|FAIRE|Gm12878, Chromatin_Structure|FAIRE|Nhek, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|FAIRE|Mcf7, Chromatin_Structure|FAIRE|Hepg2, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Ag04450, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Ag09319, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hmveclly, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Werirb1, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hct116, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hpf, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Sknmc, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Panc1, Chromatin_Structure|DNase-seq|Be2c, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|FAIRE|Panislets, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|DNase-seq|Cmk, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|TFAP2C, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|SP1, Protein_Binding|ChIP-seq|SP1, Protein_Binding|ChIP-seq|SP1, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|USF2, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|ZNF143, Protein_Binding|ChIP-seq|IRF1, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|GABPA, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|PAX5, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POU2F2, Protein_Binding|ChIP-seq|POU2F2, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|NRF1, Protein_Binding|ChIP-seq|MYC, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|PBX3, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TAL1, Protein_Binding|ChIP-seq|POU2F2, Protein_Binding|ChIP-seq|POU2F2, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TCF12, Protein_Binding|ChIP-seq|TAF1, Protein_Binding|ChIP-seq|MEF2A, Protein_Binding|ChIP-seq|MYC, Protein_Binding|ChIP-seq|PAX5, Protein_Binding|ChIP-seq|TAF7, Protein_Binding|ChIP-seq|HMGN3, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TAF1, Protein_Binding|ChIP-seq|TAF1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|GTF2B, Protein_Binding|ChIP-seq|NFYA, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|MEIS1, Protein_Binding|ChIP-seq|MEF2C, Protein_Binding|ChIP-seq|PAX5, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TAF1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|NRF1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|RFX5, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|GTF2F1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|GTF2F1, Protein_Binding|ChIP-seq|NFYB, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|ELF1

Transcription Factors   [Top]

Regulation From TransFac database

RhoA(h) + RhoGEF(m) <==> RhoA(h):RhoGEF(m) (binding)
RhoA(h) + RhoGEF(mo) <==> RhoA(h):RhoGEF(mo) (binding)
RhoA(h) + RhoGAP5(m){p} <==> RhoA(h):RhoGAP5(m){p} (binding)
RhoA(h) + RhoGDI-2(h) <==> RhoA(h):RhoGDI-2(h) (binding)
IL-1RI(h) + RhoA(h) <==> IL-1RI(h):RhoA(h) (binding)
RhoA(h) + RhoGDI-1(h) <==> RhoA(h):RhoGDI-1(h) (binding)
RhoA(h) + AKAP13-Lbc(h) <==> RhoA(h):AKAP13-Lbc(h) (binding)
RhoA(h) + AKAP13-Lbc(h) + PKA-RII(h) <==> RhoA(h):AKAP13-Lbc(h):PKA-RII(h) (binding)
RhoA(h) + Kv1.2(m.s.) <==> RhoA(h):Kv1.2(m.s.) (binding)
AKAP13(h) + RhoA(h) <==> AKAP13(h):RhoA(h) (binding)
RhoA(h) + BPGAP1(h) <==> RhoA(h):BPGAP1(h) (binding)
RhoA(h) + RhoGDI(h) <==> RhoA(h):RhoGDI(h) (binding)
BNIP-2(h) + RhoA(h) <==> BNIP-2(h):RhoA(h) (binding)
plk1(h) + RhoA(h) <==> plk1(h):RhoA(h) (binding)
RhoA(h) + RhoGAP1(h) <==> RhoA(h):RhoGAP1(h) (binding)
RHOA(h) --> RhoA(h) (expression).
P2RX7(h) --> RhoA(h) (activation)
Ost(m.s.) --> RhoA(h) (increase of exchange)
arhgef5(h) --> RhoA(h) (increase of exchange)
LAMA5(h) --> RhoA(h) (activation)
VLA-2(h) --> RhoA(h) (activation)
fibronectin(m.s.) --> RhoA(h) (regulation of localization)
alpha5-integrin(m.s.) --> RhoA(h) (regulation of localization)
beta1-integrin(m.s.) --> RhoA(h) (regulation of localization)
RHOA(h) --> RhoA(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

41ADP-ribosylasparagine (by botulinumtoxin) (Probable).Swiss-Prot 53.0
190Cysteine methyl ester.Swiss-Prot 53.0
190S-geranylgeranyl cysteine.Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr3

 Promoter: 49424030 - 49426030GSE27584

chr3

 Promoter: 49424030 - 49426030Agilent_014791_44K

chr3

 Promoter: 49424030 - 49426030Agilent_014791

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