| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5566 |
Name | PRKACA |
Synonymous | PKACA;protein kinase, cAMP-dependent, catalytic, alpha;PRKACA;protein kinase, cAMP-dependent, catalytic, alpha |
Definition | PKA C-alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A catalytic subunit |
Position | 19p13.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for PRKACA | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
PKI-gamma(h) + PKACA(h) <==> PKI-gamma(h):PKACA(h) (binding) | PKA-RI-alpha(h) + PKACA(h) <==> PKA-RI-alpha(h):PKACA(h) (binding) | RelA-p65(h) + PKACA(h) <==> RelA-p65(h):PKACA(h) (binding) | AKAP95(m) + NF-kappaB1(m.s.) + PKACA(h) <==> AKAP95(m):NF-kappaB1(m.s.):PKACA(h) (binding) | PRKACA(h) --> PKACA(h) (expression). | Sp1(h) + ATP --PKACA(h)--> Sp1(h){p} + ADP (phosphorylation) | HCV-NS5A-1A-H(HCV1AH) + ATP --PKACA(h)--> HCV-NS5A-1A-H(HCV1AH){p} + ADP (phosphorylation) | GluR1(m.s.) + ATP --PKACA(h)--> GluR1(m.s.){pS845} + ADP (phosphorylation) | phenylalanine-4-hydroxylase(h) + ATP --PKACA(h)--> phenylalanine-4-hydroxylase(h){pS16} + ADP (phosphorylation) | PKACA-isoform1(h) + PDK1-isoform1(h) <==> PKACA-isoform1(h):PDK1-isoform1(h) (binding) | PRKACA(h) --> PKACA-isoform1(h) (expression). | PRKACA(h) --> PKACA-isoform2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
2 | N-myristoyl glycine (By similarity). | Swiss-Prot 53.0 | 3 | Deamidated asparagine (By similarity). | Swiss-Prot 53.0 | 11 | Phosphoserine; by autocatalysis (Bysimilarity). | Swiss-Prot 53.0 | 140 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 196 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 198 | Phosphothreonine. | Swiss-Prot 53.0 | 202 | Phosphothreonine. | Swiss-Prot 53.0 | 339 | Phosphoserine. | Swiss-Prot 53.0 | 338 | Phosphoserine | 12509440 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 14089059 - 14091059 | Agilent_014791 |
chr19 |
Promoter: 14085492 - 14087492 | Agilent_014791 |
chr19 |
Promoter: 14085492 - 14087492 | GSE27584 |
chr19 |
Promoter: 14089059 - 14091059 | GSE27584 |
chr19 |
Promoter: 14089059 - 14091059 | Agilent_014791_44K |
chr19 |
Promoter: 14089059 - 14091059 | Agilent_014791 |