Entrez Gene

Basic Information
Gene ID	6093
Name	ROCK1
Synonymous	P160ROCK\|ROCK-I;Rho-associated, coiled-coil containing protein kinase 1;ROCK1;Rho-associated, coiled-coil containing protein kinase 1
Definition	Rho kinase\|p160 ROCK-1\|p160-ROCK\|renal carcinoma antigen NY-REN-35\|rho-associated protein kinase 1\|rho-associated, coiled-coil-containing protein kinase 1\|rho-associated, coiled-coil-containing protein kinase I
Position	18q11.1
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB [Top]
	There is no record for ROCK1

Regulation From TransFac database
Transcription Factors [Top]
RhoA(h):GTP + Rock-1(h) <==> RhoA(h):GTP:Rock-1(h) (binding)
Rock-1(h) --> GATA-4(m) (activation; phosphorylation)
Rock-1(h) --> GATA-5(m) (activation; phosphorylation)
Rock-1(h) + Aurora-A(h) <==> Rock-1(h):Aurora-A(h) (binding)
Rock-1(h) + Aurora-A(h) + DDX3(h) + HLR2(h) <==> Rock-1(h):Aurora-A(h):DDX3(h):HLR2(h) (binding)
Rock-1(h) --Caspase(h)--> protein remnants + Rock-1-p130(h) (cleavage)
Rock-1(h) --> protein remnants + Rock-1-p30(h) (cleavage)
Rock-1(h) --Caspase-3(m.s.)--> protein remnants + Rock-1-p30(h) (cleavage)
RhoA(m.s.):GTP + Rock-1(h) <==> RhoA(m.s.):GTP:Rock-1(h) (binding)
Rock-1(h) + Gem(h) <==> Rock-1(h):Gem(h) (binding)
caveolin-1(h) + Rock-1(h) <==> caveolin-1(h):Rock-1(h) (binding)
RhoE(m.s.) + Rock-1(h) <==> RhoE(m.s.):Rock-1(h) (binding)
ROCK1(h) --> Rock-1(h) (expression).
LIMK2(r) + ATP --Rock-1(h)--> LIMK2(r){pT505} + ADP (phosphorylation)
MLC(m.s.) + ATP --Rock-1(h)--> MLC(m.s.){pS} + ADP (phosphorylation)
Rock-1(h) --> Rock-1(h) (translocation)
Rock-1(h) + RhoE(m) <==> Rock-1(h):RhoE(m) (binding)
RhoE(m.s.) + Rock-1(h) <==> RhoE(m.s.):Rock-1(h) (binding)
ROCK1(h) --> Rock-1(h) (expression).
Rock-1(h) --> Rock-1(h) (translocation)
MLC(m.s.) + ATP --Rock-1(h)--> MLC(m.s.){pS} + ADP (phosphorylation)
RhoE(m) + 2 ATP --Rock-1(h)--> RhoE(m){pS7}{pS11} + 2 ADP (phosphorylation)

Post Transcriptional Modification [Top]
	There is no record for ROCK1

ENCODE RegulomeDB [Top]