Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	6648
Name	SOD2
Synonymous	IPOB\|MNSOD\|MVCD6;superoxide dismutase 2, mitochondrial;SOD2;superoxide dismutase 2, mitochondrial
Definition	Mn superoxide dismutase\|indophenoloxidase B\|manganese-containing superoxide dismutase\|mangano-superoxide dismutase\|superoxide dismutase [Mn], mitochondrial
Position	6q25.3
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr6:160100096-160183561	chr6:160100302-160100302	rs41448750	Single_Nucleotides\|eQTL\|SOD2, Single_Nucleotides\|eQTL\|CYP26A1, Single_Nucleotides\|eQTL\|SOD2, Motifs\|PWM\|NR3C1, Chromatin_Structure\|FAIRE\|Huvec, Chromatin_Structure\|DNase-seq\|Gm18507
chr6:160100096-160183561	chr6:160100302-160100302	rs7855	Single_Nucleotides\|eQTL\|SOD2, Single_Nucleotides\|eQTL\|CYP26A1, Single_Nucleotides\|eQTL\|SOD2, Motifs\|PWM\|NR3C1, Chromatin_Structure\|FAIRE\|Huvec, Chromatin_Structure\|DNase-seq\|Gm18507
chr6:160100096-160183561	chr6:160100640-160100640	rs8031	Single_Nucleotides\|eQTL\|TCP1, Motifs\|PWM\|HNF3, Motifs\|Footprinting\|Foxa2, Motifs\|Footprinting\|Foxa2, Motifs\|PWM\|Foxa2, Chromatin_Structure\|DNase-seq\|Hmec, Chromatin_Structure\|DNase-seq\|Hae, Chromatin_Structure\|DNase-seq\|Hgf, Chromatin_Structure\|DNase-seq\|Hipe, Chromatin_Structure\|DNase-seq\|Hrce, Chromatin_Structure\|DNase-seq\|Monocd14, Chromatin_Structure\|DNase-seq\|Hl60, Chromatin_Structure\|DNase-seq\|Hmveclbl, Chromatin_Structure\|FAIRE\|Gm18507, Chromatin_Structure\|DNase-seq\|Rptec
chr6:160100096-160183561	chr6:160113321-160113321	rs2842960	Single_Nucleotides\|eQTL\|TCP1, Motifs\|PWM\|Zscan4, Chromatin_Structure\|DNase-seq\|Gm12878, Chromatin_Structure\|DNase-seq\|Gm19240, Chromatin_Structure\|FAIRE\|Gm18507, Chromatin_Structure\|DNase-seq\|Helas3, Chromatin_Structure\|DNase-seq\|Hasp, Chromatin_Structure\|DNase-seq\|Hepatocytes, Chromatin_Structure\|DNase-seq\|H1hesc, Chromatin_Structure\|DNase-seq\|8988t, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A
chr6:160100096-160183561	chr6:160135577-160135577	rs9355747	Single_Nucleotides\|eQTL\|SOD2, Chromatin_Structure\|DNase-seq\|Hmvecdblad, Chromatin_Structure\|DNase-seq\|Hmvecdlyneo, Chromatin_Structure\|DNase-seq\|Hmvecdneo
chr6:160100096-160183561	chr6:160141592-160141592	rs2842966	Single_Nucleotides\|eQTL\|SOD2, Single_Nucleotides\|eQTL\|TCP1, Chromatin_Structure\|FAIRE\|Hepg2, Chromatin_Structure\|DNase-seq\|Cll
chr6:160100096-160183561	chr6:160154099-160154099	rs2758313	Single_Nucleotides\|eQTL\|SOD2, Single_Nucleotides\|eQTL\|TCP1, Chromatin_Structure\|DNase-seq\|Nhek, Chromatin_Structure\|DNase-seq\|Gm12878
chr6:160100096-160183561	chr6:160159425-160159425	rs9364534	Single_Nucleotides\|eQTL\|SOD2, Motifs\|PWM\|Oct-1, Chromatin_Structure\|FAIRE\|Gm19239, Chromatin_Structure\|DNase-seq\|Lncap
chr6:160100096-160183561	chr6:160159503-160159503	rs12204454	Single_Nucleotides\|eQTL\|SOD2, Motifs\|PWM\|Lef1, Motifs\|PWM\|Tcf7l2, Chromatin_Structure\|FAIRE\|Gm19239, Chromatin_Structure\|DNase-seq\|Lncap, Chromatin_Structure\|FAIRE\|Medullo, Chromatin_Structure\|DNase-seq\|Nhek
chr6:160100096-160183561	chr6:160161628-160161628	rs6899987	Single_Nucleotides\|eQTL\|SOD2, Chromatin_Structure\|DNase-seq\|Hnpce, Chromatin_Structure\|DNase-seq\|Lncap, Chromatin_Structure\|DNase-seq\|Hvmf, Chromatin_Structure\|DNase-seq\|Hipe, Protein_Binding\|ChIP-seq\|AR
chr6:160100096-160183561	chr6:160174456-160174456	rs1440	Single_Nucleotides\|eQTL\|TCP1, Chromatin_Structure\|DNase-seq\|Hsmm, Chromatin_Structure\|DNase-seq\|Skmc, Chromatin_Structure\|DNase-seq\|Hvmf, Protein_Binding\|ChIP-seq\|CEBPB
chr6:160100096-160183561	chr6:160181102-160181102	rs2146162	Single_Nucleotides\|eQTL\|SOD2, Chromatin_Structure\|DNase-seq\|Wi38, Chromatin_Structure\|DNase-seq\|K562, Chromatin_Structure\|DNase-seq\|Hah, Chromatin_Structure\|DNase-seq\|Hffmyc, Chromatin_Structure\|DNase-seq\|Nb4, Chromatin_Structure\|FAIRE\|K562, Chromatin_Structure\|DNase-seq\|Hcfaa, Chromatin_Structure\|DNase-seq\|Hepatocytes, Chromatin_Structure\|FAIRE\|K562
chr6:160100096-160183561	chr6:160182096-160182096	rs927450	Single_Nucleotides\|eQTL\|TCP1, Chromatin_Structure\|DNase-seq\|Huvec, Chromatin_Structure\|DNase-seq\|Hepatocytes, Chromatin_Structure\|DNase-seq\|Myometr, Chromatin_Structure\|DNase-seq\|H1hesc, Chromatin_Structure\|FAIRE\|Huvec, Chromatin_Structure\|FAIRE\|K562, Chromatin_Structure\|DNase-seq\|Hah, Chromatin_Structure\|DNase-seq\|Panc1, Protein_Binding\|ChIP-seq\|CEBPB, Protein_Binding\|ChIP-seq\|CEBPB

Regulation From TransFac database
Transcription Factors [Top]
SOD2(h) --> SOD2(h) (expression).
Aurora-A(h) + SOD2(h) <==> Aurora-A(h):SOD2(h) (binding)
SOD2(h) --> SOD2(h) (expression).
SIRT1(m) --> SOD2(h) (increase of abundance)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
68	N6-acetyllysine (By similarity).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr6	Promoter: 160033843 - 160035843	Agilent_014791
chr6	Promoter: 160033843 - 160035843	GSE27584
chr6	Promoter: 160033843 - 160035843	GSE27584
chr6	Promoter: 160033843 - 160035843	GSE27584
chr6	Promoter: 160033843 - 160035843	Agilent_014791_44K
chr6	Promoter: 160033843 - 160035843	Agilent_014791

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