| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7054 |
Name | TH |
Synonymous | DYT14|DYT5b|TYH;tyrosine hydroxylase;TH;tyrosine hydroxylase |
Definition | dystonia 14|tyrosine 3-hydroxylase|tyrosine 3-monooxygenase |
Position | 11p15.5 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for TH | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
TH(h) --> tyrosine 3-monooxygenase isoform-3(h) (expression). | TH(h) --> tyrosine 3-monooxygenase(h) (expression). | DJ-1(h) --> tyrosine 3-monooxygenase(h) (increase of abundance) | NURR1(h) --> tyrosine 3-monooxygenase(h) (increase of abundance) | tyrosine 3-monooxygenase isoform-1(h) + ATP --ERK2(m.s.)--> tyrosine 3-monooxygenase isoform-1(h){pS31} + ADP (phosphorylation) | tyrosine 3-monooxygenase isoform-1(h) + ATP --ERK(r)--> tyrosine 3-monooxygenase isoform-1(h){pS31} + ADP (phosphorylation) | TH(h) --> tyrosine 3-monooxygenase isoform-1(h) (expression). | TH(h) --> tyrosine 3-monooxygenase isoform-2(h) (expression). | TH(h) --> tyrosine 3-monooxygenase isoform-4(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
19 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 62 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 71 | Phosphoserine (by PKA) (By similarity). | Swiss-Prot 53.0 | 18 | Phosphoserine (MAPKAPK2;CaM) | 11359875;7901013;1680128 | Phospho.ELM 6.0 | 39 | Phosphoserine (MAPKAPK2;PKA) | 11359875;7901013 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 2149111 - 2151111 | GSE27584 |
chr11 |
Promoter: 2149111 - 2151111 | GSE27584 |
chr11 |
Promoter: 2149111 - 2151111 | GSE27584 |
chr11 |
Promoter: 2149111 - 2151111 | E-GEOD-20553 |
chr11 |
Promoter: 2149111 - 2151111 | E-GEOD-20553 |
chr11 |
Promoter: 2149111 - 2151111 | E-GEOD-20553 |