| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 857 |
Name | CAV1 |
Synonymous | BSCL3|CGL3|MSTP085|VIP21;caveolin 1, caveolae protein, 22kDa;CAV1;caveolin 1, caveolae protein, 22kDa |
Definition | caveolin-1|cell growth-inhibiting protein 32 |
Position | 7q31.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr7:116164839-116201233 | chr7:116173064-116173064 | rs6466583 | Single_Nucleotides|eQTL|CAV2, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Hsmmt | chr7:116164839-116201233 | chr7:116182054-116182054 | rs959173 | Single_Nucleotides|eQTL|CAV2, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|DNase-seq|Hmveclly, Chromatin_Structure|DNase-seq|Hipe |
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Transcription Factors [Top] |
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Regulation From TransFac database |
caveolin-1(h) + uPAR(m.s.):beta1-integrin(h) <==> uPAR(m.s.):beta1-integrin(h):caveolin-1(h) (binding) | caveolin-1(h) + beta1-integrin(h) <==> caveolin-1(h):beta1-integrin(h) (binding) | H-Ras(h) + caveolin-1(h) <==> H-Ras(h):caveolin-1(h) (binding) | caveolin-1(h) --> caveolin-1(h) (translocation) | caveolin-1(h) --> FAK1(h){p} (increase of phosphorylation) | Cdc42(h) + caveolin-1(h) <==> Cdc42(h):caveolin-1(h) (binding) | Rac1(h) + caveolin-1(h) <==> Rac1(h):caveolin-1(h) (binding) | caveolin-1(h) --> Cdc42(h) (regulation of protein activity) | caveolin-1(h) --> AKT-1(h){pS473} (increase of phosphorylation) | 5alphaDHT:AR(h) + caveolin-1(h) <==> 5alphaDHT:AR(h):caveolin-1(h) (regulation of localization; binding) | SHP-1(h) + caveolin-1(h) <==> SHP-1(h):caveolin-1(h) (binding) | caveolin-1(h) + STAT3(h) <==> caveolin-1(h):STAT3(h) (binding) | Hsp90(h) + caveolin-1(h) + STAT3(h) <==> Hsp90(h):caveolin-1(h):STAT3(h) (binding) | caveolin-1(h) + STAT3(h){pY} <==> caveolin-1(h):STAT3(h){pY} (binding) | GRP58(h) + Hsp90(h) + STAT1(h) + caveolin-1(h) + STAT3(h) <==> GRP58(h):Hsp90(h):STAT1(h):caveolin-1(h):STAT3(h) (binding) | ErbB1(h) + caveolin-1(h) <==> ErbB1(h):caveolin-1(h) (binding) | caveolin-1(h) + ErbB2(h) <==> caveolin-1(h):ErbB2(h) (binding) | caveolin-1(h) + ErbB1(h){pY} <==> caveolin-1(h):ErbB1(h){pY} (binding) | PKCepsilon(m) + caveolin-1(h) <==> PKCepsilon(m):caveolin-1(h) (binding) | ER-beta(h){pal} + caveolin-1(h) <==> ER-beta(h){pal}:caveolin-1(h) (binding) | ER-alpha-L(h){palC447} + caveolin-1(h) <==> ER-alpha-L(h){palC447}:caveolin-1(h) (binding) | caveolin-1(h) + ATP --> caveolin-1(h){pY14} + ADP (phosphorylation) | caveolin-1(h) + Rock-1(h) <==> caveolin-1(h):Rock-1(h) (binding) | caveolin-1(h) + atp1a1(r) <==> caveolin-1(h):atp1a1(r) (binding) | caveolin-1(h) + nostrin(m.s.) <==> caveolin-1(h):nostrin(m.s.) (binding) | caveolin-1(h) + eNOS(h) + nostrin(h) <==> caveolin-1(h):eNOS(h):nostrin(h) (binding) | endoglin(h) + Hsp90(h) + caveolin-1(h) + eNOS(h) <==> endoglin(h):Hsp90(h):caveolin-1(h):eNOS(h) (binding) | caveolin-1(h) + ptrf(h) + SDR(h) <==> caveolin-1(h):ptrf(h):SDR(h) (binding) | CAV1(h) --> caveolin-1(h) (expression). | LDL(h) --> caveolin-1(h) (increase of abundance) | caveolin-1(h) --> caveolin-1(h) (translocation) | TRAF2(h) --> caveolin-1(h) (binding) | H2O2 --> caveolin-1(h) (increase of abundance) | slc7a11(h) --/ caveolin-1(h) (decrease of abundance) | CAV1(h) --> caveolin-1alpha(h) (expression). | CAV1(h) --> caveolin-1beta(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-acetylserine. | Swiss-Prot 53.0 | 6 | Phosphotyrosine. | Swiss-Prot 53.0 | 14 | Phosphotyrosine. | Swiss-Prot 53.0 | 25 | Phosphotyrosine. | Swiss-Prot 53.0 | 37 | Phosphoserine. | Swiss-Prot 53.0 | 133 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 143 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 156 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 13 | Phosphotyrosine (Fyn;Src) | 12921535;14992595 | Phospho.ELM 6.0 | 79 | Phosphoserine | 11078729 | Phospho.ELM 6.0 | 36 | Phosphoserine | 15219854;17081983 | Phospho.ELM 6.0 | 167 | Phosphoserine | 11078729 | Phospho.ELM 6.0 | 24 | Phosphotyrosine | 15951569 | Phospho.ELM 6.0 | 5 | Phosphotyrosine | 15951569 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 115950575 - 115952575 | Agilent_014791 |
chr7 |
Promoter: 115950575 - 115952575 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 115950575 - 115952575 | GSE27584 |
chr7 |
Promoter: 115950575 - 115952575 | PMID:16328005 |
chr7 |
Promoter: 115950575 - 115952575 | PMID:16952549 |
chr7 |
Promoter: 115950575 - 115952575 | PMID:16367923 |
chr7 |
Promoter: 115950575 - 115952575 | PMID:17341888 |
chr7 |
Promoter: 115950575 - 115952575 | PMID:15375584 |
chr7 |
Promoter: 115950575 - 115952575 | PMID:11170154 |