deTS Results for Diagnoses - main ICD10: K00 Disorders of tooth development and eruption

Traits Information:

Trait ID:

172

K00
Diagnoses - main ICD10: K00 Disorders of tooth development and eruption
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=41202
# cases = 123 | # controls = 361071
# SNPs = 5641715 | # genes = 21821
1.006
p (gene) < 0.05:  # TAGs = 1103
p (gene) < 0.01:  # TAGs = 202
p (gene) < 0.001:  # TAGs = 26
p (gene) < 1.0E-4:  # TAGs = 11
p (gene) < 1.0E-5: # TAGs = 4

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.1120.06060.1470.4240.1470.4240.4240.4240.7580.6980.8580.6980.6320.4240.4930.4930.8580.8120.2380.9260.8120.1470.2950.2380.8580.06060.02070.9790.7580.9920.9870.8120.009130.1890.6980.8120.7580.3570.8120.7580.8090.4240.6320.8580.4240.3570.2380.4750.3250.7840.6370.4750.9610.990.6370.7840.8950.990.990.990.9610.7840.8950.7840.7840.1160.6370.3250.1160.2030.3250.8950.4750.2030.7840.02950.6370.7840.2030.1160.7840.8950.6370.3250.3250.4750.4750.7830.7840.7840.2030.8950.2030.6371.01.00.07530.07530.002550.2640.2640.07530.2640.2640.2640.2640.6420.2640.2640.6420.07530.07530.6420.6421.00.6420.6420.6421.00.2640.6421.00.07531.01.00.6420.2641.01.01.00.6420.6421.01.00.6411.00.6420.6421.00.6421.0Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.03260.02170.4530.09010.9750.5250.9120.5210.7850.9610.1590.2050.6590.8810.09010.4530.1590.7880.03260.00970.1210.3760.4530.9950.9990.5960.9950.1590.04680.4530.20.7880.9420.7270.08870.02170.2050.4530.2580.730.9420.8810.1590.9150.270.08610.8680.4150.9860.580.9980.9860.9980.9860.01960.001170.8660.580.740.4150.580.740.4150.01960.270.1580.4150.9860.5780.740.9480.270.4150.740.7380.9480.9480.7390.4130.01940.0430.740.4150.740.8680.580.008260.581.01.00.05750.2251.00.6021.00.6011.00.6021.00.2251.01.01.00.6021.01.00.6020.2250.05750.6010.2251.01.01.01.00.6020.2250.6021.01.01.01.01.00.6011.01.01.00.6020.6020.6020.2250.225Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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