deTS Results for Underlying (primary) cause of death: ICD10: C71.9 Brain, unspecified

Traits Information:

Trait ID:

1917

40001_C719
Underlying (primary) cause of death: ICD10: C71.9 Brain, unspecified
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=40001
# cases = 270 | # controls = 8822
# SNPs = 7087989 | # genes = 21879
1.025
p (gene) < 0.05:  # TAGs = 1360
p (gene) < 0.01:  # TAGs = 355
p (gene) < 0.001:  # TAGs = 59
p (gene) < 1.0E-4:  # TAGs = 16
p (gene) < 1.0E-5: # TAGs = 12

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.09340.3530.2430.01880.005770.1560.1970.1220.3530.4770.1560.2950.05190.2430.1560.1220.2950.3530.1220.03770.6060.09340.7260.03770.2950.1970.8660.7260.8260.1970.4770.4140.8260.2950.2950.8660.7260.4140.2430.1970.3490.8260.7790.2950.1220.5420.2950.1210.5330.1920.03990.07160.2870.1920.7790.07160.1210.1920.2870.1210.2870.5330.7790.6620.5330.2870.1920.07160.1210.8710.1920.5330.7790.9350.9350.4040.7790.2870.8710.8710.03990.6620.7790.6620.9350.7790.7790.1910.7790.5330.5330.4040.7790.7790.2680.5430.8420.8420.8420.5430.8420.8420.2680.1030.8420.8420.2680.5430.8420.8420.5430.2680.2680.03210.1030.03210.5430.2680.8420.5430.8421.00.5430.5430.03211.01.00.1031.01.00.2680.5431.01.00.1030.8420.8420.8420.8420.2680.543Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.09020.350.6760.980.9070.2410.8710.7850.9530.3530.04920.6130.04720.3530.03530.6760.02490.1940.4810.7350.4160.7290.9340.2910.4780.1940.2950.6760.6130.4810.9040.1940.9690.1170.1510.2910.2950.1940.3530.9340.1530.8750.005080.1940.1410.3280.3290.8290.9850.08410.9850.9960.9590.3290.1410.720.220.2230.02470.3290.04690.2230.720.720.5910.4520.5910.8280.9090.8290.720.3290.5910.8290.4520.2230.9850.0120.2220.8280.9090.4550.9090.720.3290.08410.2230.08410.02540.08660.2390.2391.00.5111.00.8240.510.8240.0870.5110.02510.2390.0870.2390.02540.2390.8240.8240.8240.8241.01.00.8240.2390.5110.2391.00.8240.8240.5111.00.510.2381.01.00.8240.5111.00.8240.5110.2390.0254Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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