deTS Results for Cancer code, self-reported: thyroid cancer

Traits Information:

Trait ID:

2199

20001_1065
Cancer code, self-reported: thyroid cancer
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20001
# cases = 339 | # controls = 360802
# SNPs = 7486196 | # genes = 21887
1.011
p (gene) < 0.05:  # TAGs = 1213
p (gene) < 0.01:  # TAGs = 293
p (gene) < 0.001:  # TAGs = 46
p (gene) < 1.0E-4:  # TAGs = 7
p (gene) < 1.0E-5: # TAGs = 3

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.5710.3720.1250.2050.5040.7570.5710.9980.8090.8540.6370.70.8090.8090.9750.9750.9940.9970.07090.09520.01210.1620.5710.3720.2550.8090.3110.09520.2550.5040.3720.2050.8910.2550.3110.09520.4360.2050.2050.3110.6970.3720.8540.03710.1250.4360.5710.3210.4460.08030.04450.2160.9060.8230.9960.7120.8230.8230.9060.8230.8230.9850.9580.9580.9580.1360.1360.08030.04450.5810.1360.4460.3210.1360.2160.7120.5810.2160.3210.9850.1360.08030.9060.4460.1360.9850.9960.580.2160.9580.1360.04450.3210.1360.3760.3760.7370.3760.7371.00.7371.00.1380.3760.7370.7370.7370.7371.01.01.01.00.3760.1380.7370.1381.00.3760.7371.01.00.1380.1380.7370.3760.3760.7370.3760.3760.3760.3760.3761.01.01.00.3761.00.1380.7371.00.138Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.3390.2770.6740.8790.6740.9720.7290.5360.6710.6740.4040.4040.05570.3390.280.540.6740.1390.790.1390.7350.1350.4040.40.6710.4040.07910.790.9120.4710.1350.1060.05790.4670.4670.04060.005790.7350.9380.9380.005790.4040.2260.9830.5510.8920.8030.8030.5510.9820.4110.5490.8020.9510.5510.5510.190.1920.5510.6860.5510.03690.5510.4150.1920.2890.9820.1910.6840.2920.06830.4150.8930.5510.1170.2920.5510.1910.8020.8920.9510.5510.5510.9510.06830.1920.4150.9820.3560.7210.3560.1260.3561.00.3550.3550.3550.7220.3560.03360.3551.00.3561.00.1260.3561.01.01.00.03331.00.1260.7210.3560.7220.3560.7221.01.00.7220.7220.7211.01.00.7220.7220.1261.00.1260.3560.7220.722Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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