deTS Results for Non-cancer illness code, self-reported: hypertension

Traits Information:

Trait ID:

2205

20002_1065
Non-cancer illness code, self-reported: hypertension
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20002
# cases = 93560 | # controls = 267581
# SNPs = 13586595 | # genes = 21892
1.349
p (gene) < 0.05:  # TAGs = 7481
p (gene) < 0.01:  # TAGs = 4684
p (gene) < 0.001:  # TAGs = 2589
p (gene) < 1.0E-4:  # TAGs = 1599
p (gene) < 1.0E-5:  # TAGs = 994

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.001 p < 1.0E-4 p < 1.0E-5 0.008250.3780.4720.0260.001540.8470.8160.3340.4720.4720.7440.7440.7030.9190.5670.3780.8750.8990.08570.1840.4240.3340.8470.4720.4240.0690.1840.03370.08570.660.3780.5190.08570.660.3340.4240.3780.08570.8750.7440.7780.1050.9950.4243.33E-40.6140.3340.1450.7670.7180.2670.02030.8840.9120.4880.9350.9350.9120.9120.9350.9350.6640.5480.8510.8840.2670.1150.9350.1810.5480.4880.7180.006910.01440.01440.1150.8120.2220.4880.03860.9350.1810.3720.3180.006910.6640.3180.8480.02030.9350.8514.07E-50.3720.2220.170.6930.6930.6240.2180.8610.8610.5520.970.970.8610.8610.8610.970.6930.6930.90.970.4060.09590.970.2740.09590.6930.3370.01010.170.09590.02330.2180.2740.5520.2180.90.6240.2740.2740.02330.8610.4060.8590.01010.7570.8130.09590.1290.17Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.001 p < 1.0E-4 p < 1.0E-5 0.9410.820.1260.9870.8550.9660.9380.5670.820.8820.790.9660.1460.5730.007530.8820.05280.2920.8240.001940.1260.02294.17E-40.5190.820.3350.3350.5730.1520.7520.7010.7520.06680.2110.1490.9030.5240.8820.2150.9990.9750.7520.8550.3350.9980.9970.7910.9010.9620.9460.9440.740.9730.9620.9820.8340.3310.6910.07420.8340.1940.3390.3397.07E-58.76E-40.004667.07E-50.7880.9610.2860.2380.1570.09670.2860.7370.6910.09670.3910.05480.740.5150.870.04160.9740.9960.7910.9010.1240.8650.9560.8650.6960.9720.9830.990.6930.9830.8650.8170.9340.3980.760.09240.2710.3350.4040.767.15E-40.009160.02080.001240.2680.4740.2710.04690.5520.2710.2710.8610.760.1250.6230.008940.6930.6260.9030.09240.760.990.4040.9560.477Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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