deTS Results for Non-cancer illness code, self-reported: bronchiectasis

Traits Information:

Trait ID:

2332

20002_1114
Non-cancer illness code, self-reported: bronchiectasis
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20002
# cases = 876 | # controls = 360265
# SNPs = 9079826 | # genes = 21888
1.013
p (gene) < 0.05:  # TAGs = 1305
p (gene) < 0.01:  # TAGs = 359
p (gene) < 0.001:  # TAGs = 80
p (gene) < 1.0E-4:  # TAGs = 16
p (gene) < 1.0E-5: # TAGs = 4

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.1340.02980.7010.05760.2650.1720.2150.3810.1720.2150.4440.3210.2150.4440.510.3210.510.4440.4440.2650.1030.2150.5760.1030.1030.8510.960.640.05760.5760.05760.7010.8510.4440.8510.04180.510.9730.640.640.02920.1720.9830.8510.510.1030.04180.6490.4020.6490.1280.290.07780.04480.5250.006210.01260.04480.02440.07780.4020.5250.4020.1280.5250.5250.1980.9950.4020.9860.291.00.9860.7630.9220.9220.9220.1980.8550.9860.4020.9630.1280.1980.9860.8550.9630.9210.02440.6490.8550.6490.5250.02440.6770.6771.00.6770.6770.6770.6770.6770.1970.1970.6770.6770.6770.6770.6770.6770.9060.9060.9060.9061.00.9061.00.6771.00.6770.9060.6770.9060.9060.001811.01.00.9060.9060.4060.1971.01.01.00.9050.007390.4060.4060.4061.00.0782Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.6120.1130.3490.007080.290.7350.01520.02270.5420.7890.7890.3490.1840.3490.1890.3490.1890.5450.9350.8360.7350.2830.08650.980.8740.9810.1490.6120.5450.6120.6690.06410.1490.04570.4740.3450.7350.3490.004590.9930.7890.9880.5450.3490.8270.1630.7250.001870.4760.3550.03270.001840.7230.4760.7250.4760.1620.9810.1640.7250.1030.9040.9540.7250.8270.60.9540.9940.9530.9940.1640.8270.9540.9540.4730.1030.4760.9030.9030.4740.4760.9048.01E-40.7250.6040.6040.3550.9810.6640.90.390.02330.90.90.8990.90.90.6641.00.6640.8991.00.391.00.390.6640.90.90.90.3880.90.90.91.03.16E-41.00.91.00.3880.390.390.6630.6630.90.6641.01.34E-60.6640.6640.390.390.9Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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