deTS Results for Treatment/medication code: lipitor 10mg tablet

Traits Information:

Trait ID:

2633

20003_1141146138
Treatment/medication code: lipitor 10mg tablet
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20003
# cases = 2584 | # controls = 358557
# SNPs = 10889312 | # genes = 21893
1.019
p (gene) < 0.05:  # TAGs = 1370
p (gene) < 0.01:  # TAGs = 376
p (gene) < 0.001:  # TAGs = 77
p (gene) < 1.0E-4:  # TAGs = 26
p (gene) < 1.0E-5: # TAGs = 12

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.960.9730.6060.820.7220.7220.6060.7220.7740.820.5440.7220.4810.4190.7220.6660.7740.820.9960.8930.3040.860.6060.6660.2060.8930.9880.1660.7740.004810.9430.7220.960.9880.3040.5440.5440.01070.4810.1310.1290.7220.01070.7740.4190.9730.1310.6540.850.5360.6540.3090.7620.6540.7620.850.850.6540.850.4180.7620.6540.6540.4180.9580.7620.3090.850.2170.7620.2170.2170.7620.850.002020.6540.008730.4180.05460.9820.6540.3090.9580.3090.03110.3090.2170.8490.6540.05460.2170.2170.9930.1441.00.710.710.710.710.9190.9190.9191.01.00.9191.00.711.00.9190.9190.9190.9190.9190.9190.4460.9190.4460.710.03440.710.9190.01040.715.4E-70.4460.2281.00.9190.2280.4460.9190.710.4460.4460.09620.9190.710.9190.4461.00.4461.00.2451.01.01.01.01.01.01.01.01.01.00.6231.01.01.00.6230.6230.6231.01.01.01.01.00.6230.6231.00.001991.02.25E-50.2451.01.00.6231.01.01.01.00.6230.6230.06621.01.00.6230.6231.01.0Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.9680.7930.9530.9980.320.9910.560.6260.6860.9530.9680.3790.6830.1750.1750.9080.2660.02310.9530.9080.9860.170.630.001970.05990.840.2660.9680.9080.9080.560.320.440.1720.4360.3750.5040.320.0450.03250.630.9910.440.9780.6110.6090.8230.9910.8970.9910.9460.7240.9470.9910.9910.4890.1160.7250.07210.9770.1180.02310.9470.7250.8970.002780.6110.02280.005950.6110.07210.9470.8230.9770.6070.1830.8230.6090.2660.4870.3720.7250.1830.7250.3720.9970.6110.9770.9140.2151.01.00.9141.00.6960.6970.9141.01.00.4310.6960.2160.4311.00.6980.2160.6980.9140.6980.03060.9145.18E-45.74E-90.6980.4310.6980.9140.6980.6960.6980.9140.08880.9140.9140.6980.6980.6980.9140.6981.00.6981.01.00.2251.01.01.01.01.00.6011.01.01.00.6021.01.01.01.01.00.6021.01.00.6020.01061.00.01065.75E-81.00.6021.01.00.6020.6011.01.00.2251.00.6010.6020.6021.01.00.6021.00.6021.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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