deTS Results for Treatment/medication code: rosuvastatin

Traits Information:

Trait ID:

2635

20003_1141192410
Treatment/medication code: rosuvastatin
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20003
# cases = 2227 | # controls = 358914
# SNPs = 10633265 | # genes = 21891
1.021
p (gene) < 0.05:  # TAGs = 1380
p (gene) < 0.01:  # TAGs = 314
p (gene) < 0.001:  # TAGs = 60
p (gene) < 1.0E-4:  # TAGs = 16
p (gene) < 1.0E-5: # TAGs = 14

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.1130.2740.2740.06530.06530.9860.9330.9520.9330.9520.8770.9330.9520.7970.9670.9780.6930.9670.1820.6340.8770.510.8770.5730.9990.840.7970.5730.4470.001510.6340.9080.6930.3860.6930.5730.2250.9780.8770.9520.690.9670.2740.9780.2250.840.06530.8140.5840.5840.3350.4550.9790.9790.9490.9790.9930.9930.9790.9930.8950.9490.9790.8140.8140.8140.8140.9790.8140.9790.5840.8950.8950.8950.8140.5840.007480.09280.8950.5840.4550.9490.8950.8140.8950.9790.9790.8130.9490.02940.4550.4550.8950.2320.5580.2811.01.01.01.00.850.850.850.850.850.850.850.850.850.850.850.850.2810.5580.850.851.01.00.850.851.00.2810.850.00210.03571.00.5580.850.851.01.00.850.850.850.5580.850.2810.2810.5581.00.558Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.270.380.1390.08220.5750.4460.8420.970.8440.6380.5750.9560.05890.9560.6380.5750.3840.8030.5750.6980.9380.7970.01090.01060.001190.3250.9560.03240.3840.3840.7970.5750.4460.8810.80.9550.9130.9920.1390.8830.8460.3250.8830.4460.7710.1830.1850.8660.9320.3930.9310.9310.8650.9970.8660.6530.3890.9710.7710.8660.7710.8660.9320.6530.8660.7690.03740.004420.01930.3930.7710.7710.3930.7710.7690.9710.7710.990.770.770.6530.8660.06760.2780.2780.1850.5220.3930.8330.5251.00.8331.00.8331.01.01.01.00.5260.8330.8321.00.8330.8330.5260.8331.01.00.8330.5250.2520.2523.89E-50.5260.5261.00.5261.00.8320.8331.00.8330.8330.8330.5260.8330.5260.5260.5260.02850.8331.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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