deTS Results for Illnesses of father: Chronic bronchitis/emphysema

Traits Information:

Trait ID:

3141

20107_6
Illnesses of father: Chronic bronchitis/emphysema
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20107
# cases = 36126 | # controls = 278554
# SNPs = 13585285 | # genes = 21893
1.057
p (gene) < 0.05:  # TAGs = 1828
p (gene) < 0.01:  # TAGs = 446
p (gene) < 0.001:  # TAGs = 79
p (gene) < 1.0E-4:  # TAGs = 15
p (gene) < 1.0E-5: # TAGs = 8

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.3540.850.5720.4610.1790.1170.09320.3540.3540.4610.4610.3050.1790.4070.3050.3540.8140.3050.8140.01250.1170.1460.6790.1460.07290.6790.7280.3050.6270.02380.1790.5170.852.19E-40.3540.8810.850.1460.7280.6270.5680.02380.9870.930.5720.09320.7730.2690.8550.7770.8550.5770.0050.03090.1290.3630.5770.1290.0520.08390.009570.1910.0520.1290.0520.8550.009570.6820.1910.5770.1910.4670.5770.2690.5770.9990.8550.1910.1910.6820.001210.4670.5770.4670.5770.8550.6820.6810.0050.8550.9530.4670.2690.2690.1970.6770.6770.9060.6770.02610.02610.1970.4060.4060.02610.02610.07820.07820.07820.1970.6770.07820.4060.07820.4060.9060.4060.6770.1970.6770.1970.9060.6770.9060.6770.07820.6770.1970.6770.4060.9060.4060.4060.07820.1960.4060.4060.6770.6770.1970.906Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.2420.9270.6130.9470.3370.5010.04640.2380.3330.8450.7650.6130.01340.9060.3370.5580.1060.3370.5580.7180.6130.6590.1330.2380.440.2420.2010.8780.6130.9870.1280.02720.9940.7620.03570.7620.3370.8080.6131.00.7650.9060.1060.04880.6180.6160.7220.7220.8130.3970.3920.210.5040.2120.9350.2120.5020.9670.1440.2120.2970.9350.3970.09370.05810.2090.8130.8830.8120.7220.09370.7220.1440.6180.09180.2120.8130.9670.005410.6160.6180.3970.09370.9860.3970.9350.2970.7220.6511.00.1750.6510.8950.6510.3750.3760.8940.8951.00.1750.650.6510.3760.1750.3760.3760.6510.3760.3760.650.1750.8940.8940.3760.8950.8950.3760.6510.3750.6510.6510.6510.1740.1740.1750.8950.6510.8950.1750.8951.00.895Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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