deTS Results for Home area population density - urban or rural: England/Wales - Town and Fringe - less sparse

Traits Information:

Trait ID:

3207

20118_6
Home area population density - urban or rural: England/Wales - Town and Fringe - less sparse
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20118
# cases = 25328 | # controls = 332384
# SNPs = 13586469 | # genes = 21892
1.026
p (gene) < 0.05:  # TAGs = 1300
p (gene) < 0.01:  # TAGs = 293
p (gene) < 0.001:  # TAGs = 39
p (gene) < 1.0E-4:  # TAGs = 0
p (gene) < 1.0E-5: # TAGs = 0

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.2770.06070.01510.002780.0220.1090.0820.03150.3340.2250.03150.180.0820.180.06070.1090.0820.04410.1090.06070.8980.460.8630.5930.7170.460.7720.8630.6570.5930.03150.5270.2250.1090.5930.3960.6570.0220.7170.8630.5230.1410.7720.8980.460.1090.5930.50.09330.3650.50.3650.09330.2480.1570.50.3650.02680.2480.3650.2480.1570.1570.2480.2480.2480.50.7680.8690.09330.7680.640.50.7680.9380.3650.8690.05170.2480.05170.09330.50.9380.50.50.50.7680.09260.2480.9380.8690.9380.2480.2480.6230.06641.01.01.00.2450.2450.2450.2450.2450.2450.6230.6230.6230.2450.2450.2450.06640.2451.01.01.00.2451.00.06640.2450.6230.6231.00.6230.2450.2450.6232.25E-50.2450.6230.6231.00.6230.6230.06620.6231.00.6230.6230.6230.623Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.8810.7370.04570.350.02250.06320.0310.03170.001640.2370.2910.1480.2310.9820.740.740.4810.4140.9580.6810.9390.8770.2370.2880.9120.9720.6810.740.4810.6160.110.8410.4810.8390.4780.9570.740.7940.1890.6810.9130.9980.740.4810.2220.07890.4680.610.01030.4680.07820.004520.02140.610.9280.7430.6070.9720.8530.3340.8530.2220.8530.9920.9280.9270.4680.9280.9720.9280.2220.7430.3340.1380.220.7430.8530.7420.8520.8520.7430.610.2220.3340.610.9720.8530.07950.6220.06560.6220.6220.6220.2441.00.2430.2430.6220.6220.2440.621.01.00.6221.00.6220.6221.01.00.620.6221.00.6211.00.6221.00.6220.2440.01290.06580.6220.6211.00.2430.6221.00.6220.6220.6220.6221.01.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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