deTS Results for Trouble falling asleep

Traits Information:

Trait ID:

3279

20533
Trouble falling asleep
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20533
# cases = 34491 | # controls = 11049
# SNPs = 13550919 | # genes = 21887
1.02
p (gene) < 0.05:  # TAGs = 1281
p (gene) < 0.01:  # TAGs = 310
p (gene) < 0.001:  # TAGs = 53
p (gene) < 1.0E-4:  # TAGs = 18
p (gene) < 1.0E-5: # TAGs = 16

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.4130.1940.950.9660.9980.008150.01220.01220.00220.00220.05010.02565.07E-40.02560.02560.01220.1540.03620.2930.9860.8290.9660.3510.7290.9970.2410.4130.7290.670.9020.06820.7290.06820.9020.6080.6080.950.9290.7290.8690.4740.2410.8290.670.7820.4130.1940.1250.2930.8750.6680.9370.5390.5390.1250.005190.005190.6680.6680.410.5390.1970.1250.6680.6680.1970.7840.2930.8750.1250.410.8750.410.7840.8750.8750.9910.2930.410.410.410.9370.6680.9730.5390.5390.5390.9360.6680.7840.7840.8750.410.410.7620.7620.7621.00.7620.04890.04890.01160.01160.01160.04890.04890.01160.04890.04890.01160.04890.01160.7620.7620.7621.00.1620.4120.7620.7620.7620.4121.01.00.7621.01.01.00.7621.00.7620.7620.4120.4120.7620.7620.4120.7621.00.4120.162Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.8810.740.9570.4220.120.2990.150.3550.1180.3580.4220.09070.9880.9570.8810.7430.9380.8420.4220.1960.5550.6780.6210.4840.2410.8810.9930.6210.5550.7430.8770.6840.5550.6810.1940.6180.6210.9980.4220.7430.9570.4880.6210.9130.9280.3781.00.5090.5090.7620.5050.06250.5070.8590.1750.380.9890.7620.9890.5090.5090.6410.5090.7620.7620.8570.380.9270.8580.7620.6410.380.5090.5090.3760.6410.380.5070.03410.2650.2670.9690.1750.5090.9690.9890.7620.5091.00.7481.01.01.00.3921.00.3920.3920.1490.3920.7491.00.1490.7490.1490.7490.3920.7490.7491.00.3910.7491.01.00.7490.7490.7490.7490.7490.3910.7491.00.1490.1490.3920.1490.7490.3920.3920.7491.00.7491.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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