deTS Results for Diagnoses - main ICD10: D25 Leiomyoma of uterus

Traits Information:

Trait ID:

360

D25
Diagnoses - main ICD10: D25 Leiomyoma of uterus
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=41202
# cases = 5507 | # controls = 355687
# SNPs = 12248823 | # genes = 21888
1.008
p (gene) < 0.05:  # TAGs = 1608
p (gene) < 0.01:  # TAGs = 400
p (gene) < 0.001:  # TAGs = 81
p (gene) < 1.0E-4:  # TAGs = 24
p (gene) < 1.0E-5: # TAGs = 14

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.1850.550.4330.550.6650.7180.850.8830.550.7180.8110.9520.850.7670.850.8830.9110.550.2720.8110.9110.4910.550.7180.07150.2720.6090.02160.05420.1490.7180.7670.1850.8110.6090.3760.1850.07150.01080.01540.5460.550.4330.4910.1490.4910.4330.09380.4090.5230.2160.5230.3050.5230.2160.8330.6380.4090.4090.3050.5230.3050.3050.5230.4090.4090.9010.6380.7440.8330.9470.9750.5230.8330.3050.8330.9010.6380.7440.6380.9750.5230.2160.9470.6380.2160.2160.3030.4090.4090.6380.5230.5230.5230.2390.4590.4590.2390.2390.7210.7210.7210.7210.7210.7210.7210.7210.9230.7210.9230.7210.9230.2390.4590.7210.4591.00.7210.7210.7210.7211.00.2390.9230.9230.9230.7210.7210.03750.003120.7210.4590.7210.7210.1030.4590.4590.7210.01160.9230.7210.2080.2080.5820.5820.5820.5820.5821.00.5820.5820.5820.5820.5821.01.01.01.01.00.5821.01.01.01.01.01.00.5820.5821.00.2080.5820.5821.00.2080.5820.05010.5820.5821.01.01.01.01.00.2080.5820.2080.5820.582Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.920.9570.1880.5630.5630.980.6140.9180.6750.6220.1510.780.5540.6780.8240.3290.9410.4420.6220.4420.09340.2230.02110.01010.02050.9410.8240.230.230.3290.3760.8240.04010.3250.05280.03920.3290.5630.6780.3840.9980.9870.8240.07160.2650.880.4780.3650.2650.9350.2620.880.4760.9350.1830.3650.8010.4780.7070.1830.9960.7070.8040.7070.1830.07340.120.5930.5930.4780.8040.5950.5950.1830.5910.7070.1830.2640.1820.1190.5950.4780.5950.3650.8810.9690.8040.04450.4310.6970.9140.2160.08931.00.08840.9140.2150.6980.4310.4310.9140.9141.00.6981.00.2160.9140.9140.6981.00.2160.9140.9140.6980.9140.2160.4310.2160.08840.08930.08930.6970.002320.430.6980.6980.6980.4310.6980.9140.6980.4310.2070.581.00.04970.5811.00.580.580.580.2070.5810.5810.581.01.01.01.00.5811.00.5810.5811.00.04970.580.580.2070.5810.2070.2070.2070.580.04970.5811.00.581.01.00.5810.5810.2070.5811.00.5810.581Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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