deTS Results for Iron

Traits Information:

Trait ID:

4071

100011_irnt
Iron
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=100011
# cases = 0 | # controls = 51453
# SNPs = 13550187 | # genes = 21888
1.034
p (gene) < 0.05:  # TAGs = 1543
p (gene) < 0.01:  # TAGs = 385
p (gene) < 0.001:  # TAGs = 50
p (gene) < 1.0E-4:  # TAGs = 2
p (gene) < 1.0E-5: # TAGs = 0

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.7490.3010.9260.7490.2520.2080.2520.04780.1360.1070.02580.2520.1360.2080.0830.03540.1690.0830.7490.006270.0830.01860.7490.02580.4680.1360.3010.1070.7490.6430.4090.6430.1690.2080.9260.6980.06350.9020.6980.5860.2050.3530.4680.6980.6430.9610.2080.9540.8490.9540.9920.9120.5510.7650.3310.5510.5510.4380.7650.2390.3310.2390.2390.03970.06680.9120.6640.1640.6640.9920.3310.9540.6640.8490.1070.6640.2390.5510.8490.6640.2390.4380.9540.03970.5510.9790.9540.5490.4380.3310.6640.9540.9920.4380.8581.00.5730.8580.8580.5730.8580.5730.8580.8580.8580.8580.5730.5730.8580.5730.2950.5731.00.120.2950.120.5730.121.00.8581.00.2950.8581.00.8580.2950.2950.8580.01071.00.03950.5730.5730.2950.8570.2950.8580.5730.120.2950.573Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.5990.4140.7120.8820.1080.5990.590.4140.5350.3070.8080.7120.3530.1720.2120.08340.5390.1370.5990.01270.1080.06070.5990.7590.6530.2570.3070.1080.2570.4780.470.8080.8820.08170.5350.8050.5990.3610.4780.990.9670.7620.7620.3610.9720.8910.9420.8920.5010.6170.890.1980.3850.1330.8190.7260.9410.3880.6170.3880.5010.8190.9720.2850.7260.008080.8920.1320.2830.6170.7260.20.5010.7260.4970.8190.7260.4990.1980.3850.7260.3880.6170.8920.9420.7260.7260.2850.8491.00.8491.01.00.8490.5550.110.2790.5570.8490.8490.2780.5570.5570.280.5570.5571.00.8490.8490.03490.281.01.00.5571.00.1110.280.280.5550.280.1111.00.2790.2790.8490.1110.8490.8490.5571.00.8490.557Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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