deTS Results for Illnesses of father: Bowel cancer

Traits Information:

Trait ID:

4393

20107_4_v2
Illnesses of father: Bowel cancer
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=20107
# cases = 18690 | # controls = 294065
# SNPs = 13585275 | # genes = 21889
1.016
p (gene) < 0.05:  # TAGs = 1445
p (gene) < 0.01:  # TAGs = 342
p (gene) < 0.001:  # TAGs = 45
p (gene) < 1.0E-4:  # TAGs = 7
p (gene) < 1.0E-5: # TAGs = 2

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.2880.3420.5220.2880.5830.5220.2880.9320.8780.9520.40.460.7530.9660.9320.8420.9080.8420.5220.1570.7530.2880.1570.40.80.8420.80.9940.1240.5220.9320.09610.1570.3420.6430.07340.1570.004660.02110.02110.9310.80.1950.3420.2880.01030.80.7140.3590.3590.1110.3590.2560.3590.3590.7140.9440.8140.7140.7140.7140.2560.3590.9440.4760.8910.1730.8140.02110.8910.2560.2560.4760.4760.7140.4760.1110.9750.1110.2560.2560.5980.9440.7140.03870.002560.002560.9430.4760.5980.3590.4760.3590.7140.7860.4460.7860.06050.1880.4460.4460.4461.01.00.4460.4460.4460.7860.1880.4460.7860.7861.00.06050.4460.003240.4460.1880.7860.7860.7861.00.4460.06050.7860.7860.1881.00.7860.7860.7860.1880.4460.4460.7850.4460.06051.00.4460.4460.786Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.9140.9370.5260.760.9140.4010.8020.8830.7030.9560.7070.8080.1870.1920.1540.1920.2870.5260.2370.6490.9380.9860.1920.9550.3970.4010.850.8080.7070.120.9110.850.05240.190.05130.2340.009250.7070.9560.8080.2870.980.05240.4630.9320.3180.320.5580.6790.2230.6750.6770.3180.9320.320.7870.3160.4340.5580.9320.1470.6790.2230.6790.8720.9310.6790.6770.4320.2230.2230.7870.6790.6790.3160.5580.5580.6770.05320.5560.003840.1470.9320.9690.4340.8720.2230.5580.7730.7730.7730.7730.4280.4280.7720.7730.4270.4281.00.7730.05350.1740.4280.7730.1740.4280.7731.00.7731.00.7730.1730.1730.4280.7731.00.4281.01.00.4281.00.1730.4271.00.4280.7730.7730.4281.00.7730.4280.773Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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