deTS Results for Anaesthetics administered during delivery: Spinal anaesthetic

Traits Information:

Trait ID:

4503

41219_3_v2
Anaesthetics administered during delivery: Spinal anaesthetic
UK Biobank (UKBB)
Neale Lab, 2018
http://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=41219
# cases = 1254 | # controls = 2526
# SNPs = 9673174 | # genes = 21891
1.007
p (gene) < 0.05:  # TAGs = 1248
p (gene) < 0.01:  # TAGs = 236
p (gene) < 0.001:  # TAGs = 24
p (gene) < 1.0E-4:  # TAGs = 8
p (gene) < 1.0E-5: # TAGs = 5

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.2810.05970.2810.4030.470.7860.8750.5380.670.8340.7310.9080.8750.6050.8340.6050.470.1810.1810.5380.9350.1810.9550.4030.6050.2280.2810.8340.970.08120.470.2810.340.9350.470.5380.7310.2810.9350.9080.9880.9990.01430.970.7310.8340.5380.4240.01230.1030.2870.2870.9320.9770.8480.7260.8480.9320.9320.9770.9320.7260.8480.5770.8480.4240.2870.1790.1790.7260.4240.1030.9320.8480.5770.9320.4240.4240.7260.05460.7260.5770.1790.9320.8480.5770.4240.9310.9950.1790.9990.8480.4240.4241.00.4870.4870.4870.4870.4870.4870.4870.4870.4870.4870.4870.4870.4870.4870.4871.01.01.00.1350.4870.1350.4870.1351.00.1350.1350.4871.01.01.00.4870.02441.00.4870.4871.00.4871.01.00.4861.00.02441.00.4870.4870.487Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.4570.5920.5950.6620.7240.2680.5190.7210.4540.05380.03830.390.6550.830.390.9340.4570.5950.3270.05380.2680.9320.170.2130.0120.09970.7240.5260.5950.3270.9530.170.780.970.0980.9050.830.170.9550.2160.9070.2680.780.5950.3670.2360.3670.8140.9690.07710.8120.8130.8130.520.6770.3670.03820.2370.2370.520.1410.520.9120.3670.9120.9110.6770.3650.07650.3670.6770.3670.1410.03890.2350.1410.3670.9680.6760.6760.1410.03890.8140.520.9920.9120.520.2371.01.00.1181.01.01.01.00.1170.4581.01.00.4590.1170.4590.1180.4590.4591.00.4590.1180.1180.4580.4591.01.01.01.01.00.01931.01.01.00.4590.4581.01.01.01.01.00.1181.01.01.01.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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