deTS Results for White matter hyperintensity volume

Traits Information:

Trait ID:

5307

Brain volume
White matter hyperintensity volume
Expanded Trait Collection (ETC)
Traylor, 2019
30659137
# cases = 0 | # controls = 8429
# SNPs = 7600586 | # genes = 21943
1.048
p (gene) < 0.05:  # TAGs = 1589
p (gene) < 0.01:  # TAGs = 399
p (gene) < 0.001:  # TAGs = 70
p (gene) < 1.0E-4:  # TAGs = 27
p (gene) < 1.0E-5: # TAGs = 14

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.6540.4830.001580.02210.2680.9460.9810.9810.9610.9810.9730.9920.9730.9460.9810.9950.9610.9730.7070.8410.9610.2230.4830.1830.1180.6540.5410.07170.7570.8410.1830.5990.370.2680.7070.09270.8410.2680.07170.1180.8730.0410.9610.370.0410.4250.3170.6590.6590.1040.160.5460.7610.7610.6590.4320.5460.6590.910.5460.7610.6590.8460.7610.7610.7610.9780.9780.6590.8460.8460.910.9780.3260.3260.5460.6590.160.2340.2340.7610.7610.6590.8460.3260.4320.4320.8450.02170.910.5460.3260.4320.160.4060.4060.1970.07820.4060.6770.6770.6770.6770.9060.6770.6770.6770.6770.6770.6771.00.9060.4060.9060.9060.4060.6770.6771.01.00.6770.6771.00.001810.4060.6770.4060.6770.4060.9060.6770.6770.001813.86E-40.9050.1971.00.4060.4060.1970.6770.05010.05010.2080.2080.5821.01.01.01.01.01.01.01.01.01.01.01.01.00.05010.5820.5820.2080.5820.5821.01.00.2080.5821.00.008740.5820.5820.5820.5820.05010.5821.00.5820.05010.05011.00.2081.00.5820.2080.5820.582Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.870.5780.1050.90.8340.9450.6870.5190.9440.9610.640.2970.7390.90.1660.870.4050.4050.3490.5820.5820.02370.7930.790.6910.1050.1050.5820.2970.640.008230.5230.7460.7430.1030.01740.5820.9450.1660.9450.2480.1660.4640.90.9350.7050.1830.9870.7070.8810.7030.7050.8030.5950.1830.7070.8790.7070.07490.9870.3650.5950.1830.5950.7070.4730.8040.7050.7050.1830.1830.4780.4780.1830.180.9350.9870.5930.1190.2640.4780.8810.2650.9870.7070.04450.07490.2650.6750.6750.07731.00.6751.00.4020.4030.6750.9050.6750.9050.9040.9050.1951.00.9050.9050.6750.6750.9050.1940.4040.02550.001750.6750.1950.9050.6750.4040.1940.6751.00.6750.4030.00720.007260.4040.4040.9050.6750.9050.9050.6750.5810.2060.2071.00.5811.00.581.01.00.5811.01.01.00.5810.2071.01.01.00.5810.2070.5810.580.5810.2060.04950.5810.2071.00.5810.2070.2060.5811.00.580.580.2060.5810.5810.2071.00.5811.01.01.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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