deTS Results for Primary_lymphoid and hematopoietic malignant neoplasms

Traits Information:

Trait ID:

650

C3_PRIMARY_LYMPHOID_HEMATOPOIETIC
Primary_lymphoid and hematopoietic malignant neoplasms
UK Biobank (UKBB)
Neale Lab, 2018
N/A
# cases = 2710 | # controls = 358484
# SNPs = 10971615 | # genes = 21890
1.011
p (gene) < 0.05:  # TAGs = 1301
p (gene) < 0.01:  # TAGs = 352
p (gene) < 0.001:  # TAGs = 83
p (gene) < 1.0E-4:  # TAGs = 22
p (gene) < 1.0E-5: # TAGs = 14

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.6450.8520.8090.8520.9180.6450.5810.5810.3280.4520.4520.7050.5160.8520.5810.7050.3880.4520.9730.1790.6450.9730.1090.9180.9410.5160.3880.5810.7050.760.3280.8090.6450.9180.8090.9990.9180.7050.02290.01580.7010.01580.7050.2230.03240.03240.04510.5120.6320.2870.7430.9060.7430.7430.9060.7430.5120.6320.7430.7430.6320.9530.9060.3940.6320.7430.6320.7430.9530.2870.9530.6320.8370.8370.3940.6320.6320.001620.0810.9060.8370.8370.9920.9060.6320.2870.130.2867.18E-40.5120.5120.01430.02680.003510.2280.4460.4460.710.9190.710.710.710.710.710.710.710.710.710.710.710.710.9190.2280.9190.9190.9190.4461.00.9190.4460.710.710.710.9190.09660.4460.710.4460.710.710.9190.710.710.9191.00.03440.9190.9190.09660.09660.01040.1710.5370.1710.5371.00.5370.5370.5370.5370.5370.5370.5370.5370.5370.5370.5371.01.00.5371.01.00.5371.01.01.00.5371.01.01.01.00.1711.01.00.5371.01.00.5371.00.5370.5371.00.5371.00.5370.005430.1710.0361Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 0.7830.4060.8310.3470.9870.410.7780.6030.9510.1490.9310.9520.5340.1150.4750.06510.670.9520.7830.2360.2360.08440.2360.6030.6670.670.04750.9310.5410.4750.8260.4750.9520.2860.930.04650.004830.9050.01650.9520.3470.9050.9790.410.5990.1110.360.8150.9990.5990.9910.8910.9970.360.9440.9910.4730.1740.2570.06770.5990.06770.9750.7150.8920.1720.02130.1110.3580.8920.02130.4770.9750.06770.8130.4770.9440.1730.3580.3580.2570.8921.31E-60.9440.4770.9910.8920.7150.6870.4160.910.6871.00.910.9090.9090.9090.910.2050.910.4160.6870.6870.2050.6870.4170.4170.4170.4170.6850.08320.4160.9090.910.2050.6870.911.00.4160.2050.6870.6860.6860.6860.910.910.02830.910.6870.4170.4170.6871.01.00.4861.01.01.01.01.01.01.00.1351.00.1341.00.1350.4860.1351.01.00.4861.01.00.4860.4851.01.00.1351.01.01.00.0240.02421.00.4850.4850.1340.4860.4861.01.00.4861.01.00.486Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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