deTS Results for Other diseases of the digestive system

Traits Information:

Trait ID:

885

K11_OTHDIG
Other diseases of the digestive system
UK Biobank (UKBB)
Neale Lab, 2018
N/A
# cases = 7063 | # controls = 354131
# SNPs = 12651918 | # genes = 21888
1.022
p (gene) < 0.05:  # TAGs = 1438
p (gene) < 0.01:  # TAGs = 434
p (gene) < 0.001:  # TAGs = 174
p (gene) < 1.0E-4:  # TAGs = 134
p (gene) < 1.0E-5:  # TAGs = 111

Manhattan Plot of All SNPs in the GWAS




Manhattan Plot of All Genes in the GWAS


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deTS Enrichment Analysis Using the GTEx Panel


p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 p < 1.0E-5 0.7760.9830.4190.6070.3580.5450.6070.7240.9620.9890.6680.6680.3580.6070.8620.6680.8620.6070.7240.6070.2040.07550.6680.4810.6680.7760.9450.7240.07550.09930.02980.6070.3580.6070.8220.7240.4190.6070.6680.7240.04055.12E-50.7760.6070.05640.8960.04140.9940.9980.8840.8130.9350.5060.5060.3960.8130.6170.6170.7220.6170.3960.3960.3960.6170.6170.8840.5060.6170.2120.8130.5060.7220.8840.9860.9940.2120.7226.02E-40.6170.9980.8840.9860.8840.8130.6170.6170.7220.217.0E-60.3960.9350.1440.3960.002740.7830.9720.7830.9050.9960.7830.7830.7830.9050.9050.9050.9050.9050.9050.7830.7830.7830.9050.9050.6160.08320.6160.9720.7830.6160.9720.9960.9720.6160.6162.45E-70.9721.00.9720.7830.9720.9720.7830.160.2790.08275.09E-80.4380.9960.01680.4380.006590.6010.9240.7910.9240.9860.9240.9240.9240.9240.9240.9240.9240.9240.9240.9240.9240.9240.9860.9240.9240.6010.7910.9860.9860.7910.9861.00.9240.6010.6015.78E-70.9861.00.9240.6010.9240.9240.9240.2340.2340.121.08E-70.6011.00.05510.6018.22E-40.4770.8760.8760.9741.00.8760.8760.8760.8760.8760.8760.8760.8760.8760.8760.8760.9740.9740.8761.00.6960.9740.9741.00.8760.9741.00.8760.4770.4773.13E-70.9741.00.8760.4770.9740.9740.8760.1430.1430.06335.16E-80.6961.00.06360.6967.44E-4Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel


p < 0.05 p < 0.01 p < 0.001 p < 1.0E-4 p < 1.0E-5 0.9180.9960.8890.9980.5230.9590.2240.6460.7050.650.7090.9180.2240.1140.230.1860.3960.5230.9820.8110.9410.580.1860.1120.3330.9720.2810.8110.8110.8110.9960.8890.3360.2770.9170.02420.3360.3968.55E-40.9590.8890.9410.7630.650.9150.8520.9560.980.3370.9990.3330.5560.7690.670.9150.9150.5540.5580.3370.1680.3370.770.9990.8530.9150.2410.4440.1090.7690.9920.006620.770.9920.9150.9920.5580.5580.6680.8520.006510.1680.4441.12E-80.670.9150.9920.980.980.7680.7670.9690.9690.7680.9690.9680.9680.8960.8970.9690.9950.5940.1470.8970.2610.7680.5971.00.9690.9690.07360.1470.01420.7670.9691.39E-50.7681.00.8970.8960.2610.9690.1460.8960.07410.2610.7681.15E-90.5970.9950.9950.9950.8970.7750.7740.9170.9840.7750.9840.9840.9840.9170.9170.9841.00.7740.5790.7750.5790.7750.3781.00.9840.9840.01880.2160.006720.5780.9171.96E-60.7751.00.7750.7740.1080.9840.3770.9170.04780.2160.7753.66E-110.5791.01.00.9840.9170.6750.8640.8650.9710.9710.9710.9710.9710.8640.9710.9711.00.8640.6750.8650.4520.8650.4521.00.9711.00.006870.260.1280.4510.8656.15E-61.01.00.6750.6730.1290.9710.2590.8640.0550.260.9719.25E-120.8651.01.01.00.865Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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