deTS Results for Lung diseases due to external agents

Traits Information:

Trait ID:

921

J10_EXTERLUNG
Lung diseases due to external agents
UK Biobank (UKBB)
Neale Lab, 2018
N/A
# cases = 281 | # controls = 360913
# SNPs = 7158902 | # genes = 21881
1.007
p (gene) < 0.05:  # TAGs = 1225
p (gene) < 0.01:  # TAGs = 251
p (gene) < 0.001:  # TAGs = 32
p (gene) < 1.0E-4:  # TAGs = 10
p (gene) < 1.0E-5: # TAGs = 2

Manhattan Plot of All SNPs in the GWAS



Manhattan Plot of All Genes in the GWAS

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deTS Enrichment Analysis Using the GTEx Panel

p < 0.05 p < 0.01 p < 0.001 0.6560.1370.5910.7170.3290.5910.7170.7730.4570.4570.4570.4570.6560.6560.3910.7730.7730.8650.3290.5240.6560.1750.04160.02940.5910.9780.9660.90.5910.90.5910.4570.6560.1370.90.2720.4570.9280.1370.1370.820.9280.1750.950.05760.2720.1750.4720.2250.7460.6130.4720.4720.6130.8550.3380.2250.4720.7460.7460.7460.3380.8550.9290.7460.7460.6130.9290.4720.3380.4720.3380.9290.9290.6130.9290.9290.02230.8550.3380.08120.9720.9290.8550.8550.7460.7460.8540.4720.08120.8550.9290.3380.02230.09460.003980.6770.6770.6771.01.01.00.3020.3021.01.01.01.00.3021.01.01.00.6770.3021.00.6771.00.3020.09461.00.6771.01.00.6770.09460.6771.00.6771.00.3021.01.01.01.01.01.00.3020.6771.01.00.677Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel

p < 0.05 p < 0.01 p < 0.001 0.850.5570.2980.2980.2980.4920.4160.2390.2940.4920.560.7510.0620.1510.06440.4240.2420.9620.9850.7510.9620.9420.1510.3550.9430.560.9620.03290.6920.6280.08430.8890.7510.3550.9180.6240.4920.6920.4920.6280.560.4920.8040.1940.190.8270.2950.2950.2950.9140.5650.4230.8270.8280.8280.8280.7060.7090.190.8280.5690.8280.9140.5690.7090.7060.5690.4230.7080.4250.190.06360.2950.5690.2920.8280.9650.7080.8270.9130.5690.4250.03310.2950.7090.06360.7090.8280.30.09360.09390.6750.6751.01.01.01.01.00.6750.6750.6741.00.09391.00.6750.6750.6750.6750.6751.01.00.30.6750.6750.6750.6751.00.30.6741.00.6751.00.31.01.00.6751.00.30.6750.09391.00.0218Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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