Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1029

Name

CDKN2A

Synonym

ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16;cyclin-dependent kinase inhibitor 2A;CDKN2A;cyclin-dependent kinase inhibitor 2A

Definition

CDK4 inhibitor p16-INK4|cell cycle negative regulator beta|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)|multiple tumor suppressor 1

Position

9p21

Gene Type

protein-coding

TSG scores

Description

TUSON ranking

3

TUSON P-value

9.81E-96

Pathways and Diseases

Pathway

Regulation of retinoblastoma protein;PID Curated;200191

Pathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha;PID Curated;200122

Pathway

cell cycle: g1/s check point;PID BioCarta;100160

Pathway

FOXM1 transcription factor network;PID Curated;200120

Pathway

C-MYC pathway;PID Curated;200093

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

p53 pathway;PID Curated;200175

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237

Pathway

ctcf: first multivalent nuclear factor;PID BioCarta;100194

Pathway

E2F transcription factor network;PID Curated;200027

Pathway

Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106

Pathway

AP-1 transcription factor network;PID Curated;200118

Pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2;PID Curated;200044

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

cyclins and cell cycle regulation;PID BioCarta;100207

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Coregulation of Androgen receptor activity;PID Curated;200038

Pathway

C-MYB transcription factor network;PID Curated;200130

Pathway

Cell Cycle, Mitotic;Reactome;REACT:152

Disease

esophageal squamous cell carcinoma;GAD

Disease

familial melanoma;GAD

Disease

Oral cancer;FunDO

Disease

Eating disorder;FunDO

Disease

Diabetes;KEGG DISEASE

Disease

Skin cancers;KEGG DISEASE

Disease

Osteosarcoma;KEGG DISEASE;H00036

Disease

Viral infections;KEGG DISEASE

Disease

Hamman-Rich syndrome;FunDO

Disease

Non-small cell lung cancer;KEGG DISEASE;H00014

Disease

Orolaryngeal cancer, multiple;OMIM

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Stroke;GAD

Disease

Penile cancer;KEGG DISEASE;H00025

Disease

Li-Fraumeni syndrome;OMIM

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Hypertension;FunDO

Disease

Malignant melanoma;KEGG DISEASE;H00038

Disease

Burkitt lymphoma;KEGG DISEASE;H00008

Disease

Nasopharyngeal cancer;KEGG DISEASE;H00054

Disease

Abdominal aortic aneurysm;NHGRI

Disease

Type II diabetes mellitus;KEGG DISEASE;H00409

Disease

Cancer;FunDO

Disease

Adult T-cell leukemia;KEGG DISEASE;H00009

Disease

myocardial infarct;GAD

Disease

Pancreatic cancer;KEGG DISEASE;H00019

Disease

overall effect;GAD

Disease

Coronary heart disease;NHGRI

Disease

Infections caused by retro-transcribing viruses;KEGG DISEASE

Disease

Ulcerative colitis;FunDO

Disease

Herpes;FunDO

Disease

oligodendrogliomas;GAD

Disease

hypertension;GAD

Disease

Emphysema;FunDO

Disease

Pancreatitis;FunDO

Disease

coronary heart disease;GAD

Disease

Pancreatic cancer/melanoma syndrome;OMIM

Disease

Kidney disease;FunDO

Disease

Cirrhosis;FunDO

Disease

Myocardial infarction;NHGRI

Disease

Breast cancer;NHGRI

Disease

Coronary Disease;GAD

Disease

melanoma;GAD

Disease

Glioma;GAD

Disease

Papillomavirus infection;FunDO

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Cancers of soft tissues and bone;KEGG DISEASE

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Myocardial infarction (early onset);NHGRI

Disease

Type 2 diabetes;NHGRI

Disease

AGING;GAD

Disease

type 2 diabetes;GAD

Disease

adult T-cell leukemia;GAD

Disease

Adrenal gland hyperfunction;FunDO

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

breast cancer melanoma;GAD

Disease

Malignant pleural mesothelioma;KEGG DISEASE;H00015

Disease

diabetes, type 2;GAD

Disease

Coronary Artery Disease;GAD

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Adenovirus infection;FunDO

Disease

lung carcinoma;GAD

Disease

Laryngeal cancer;KEGG DISEASE;H00055

Disease

Squamous cell carcinoma;KEGG DISEASE;H00040

Disease

Cancers;KEGG DISEASE

Disease

Metabolic diseases;KEGG DISEASE

Disease

non-small cell lung carcinoma;GAD

Disease

Congenital abnormality;FunDO

Disease

ovarian cancer;GAD

Disease

Esophageal cancer;KEGG DISEASE;H00017

Disease

Protein-energy malnutrition;FunDO

Disease

Cholangiocarcinoma;KEGG DISEASE;H00046

Disease

Malignant islet cell carcinoma;KEGG DISEASE;H00045

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

Intracranial aneurysm;NHGRI

Disease

physical function;GAD

Disease

Chronic myeloid leukemia (CML);KEGG DISEASE;H00004

Disease

bladder cancer;GAD

Disease

Parkinson disease;FunDO

Disease

Actinic keratosis;FunDO

Disease

Glioma;NHGRI

Disease

Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

pancreatic cancer;GAD

Disease

Melanoma;NHGRI

Disease

Diabetes mellitus;FunDO

Disease

Melanoma and neural system tumor syndrome;OMIM

Disease

Neurofibromatosis 1;GAD

Disease

CARDIOVASCULAR;GAD

Disease

CANCER;GAD

Disease

Myocardial Infarction;GAD

Disease

Endometriosis;FunDO

Disease

Gallbladder cancer;KEGG DISEASE;H00047

Disease

Melanoma, cutaneous malignant, 2;OMIM

Disease

NEUROLOGICAL;GAD

Disease

myocardial infarction (early onset);GAD

Disease

Glioma;KEGG DISEASE;H00042

Disease

Intracranial Aneurysm;GAD

Disease

Barrett's esophagus;FunDO

Disease

Head and neck cancers;KEGG DISEASE

External Links

Links to Entrez Gene

1029

Links to all GeneRIF Items

1029

Links to iHOP

1029

Sequence Information

The sequences provided here are only the longest representative sequences, not covering all the isoforms.

Nucleotide Sequence

>1029 : length: 471
atggagccggcggcggggagcagcatggagccttcggctgactggctggccacggccgcg
gcccggggtcgggtagaggaggtgcgggcgctgctggaggcgggggcgctgcccaacgca
ccgaatagttacggtcggaggccgatccaggtcatgatgatgggcagcgcccgagtggcg
gagctgctgctgctccacggcgcggagcccaactgcgccgaccccgccactctcacccga
cccgtgcacgacgctgcccgggagggcttcctggacacgctggtggtgctgcaccgggcc
ggggcgcggctggacgtgcgcgatgcctggggccgtctgcccgtggacctggctgaggag
ctgggccatcgcgatgtcgcacggtacctgcgcgcggctgcggggggcaccagaggcagt
aaccatgcccgcatagatgccgcggaaggtccctcagacatccccgattga

Protein Sequence

>1029 : length: 156
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVA
ELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE
LGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD



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