| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 2137 |
Name | EXTL3 |
Synonym | BOTV|EXTL1L|EXTR1|REGR|RPR;exostosin-like glycosyltransferase 3;EXTL3;exostosin-like glycosyltransferase 3 |
Definition | EXT-related 1|exostoses (multiple)-like 3|exostosin tumor-like 3|exostosin-like 3|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|hereditary multiple exostoses gene isolog|putative tumor suppressor protein EXTL3|reg receptor |
Position | 8p21 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6724 |
TUSON P-value | 1 |
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Pathways and Diseases |
|
Pathway | Glycosaminoglycan biosynthesis - heparan sulfate;KEGG PATHWAY;hsa00534 |
Pathway | heparan sulfate biosynthesis;BioCyc;PWY-6564 |
Pathway | heparan sulfate biosynthesis (late stages);BioCyc;PWY-6558 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Disease | Colon cancer;FunDO |
Disease | Adenoma;FunDO |
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External Links |
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Links to Entrez Gene | 2137 |
Links to all GeneRIF Items | 2137 |
Links to iHOP | 2137 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2137 : length: 2760 atgacaggctataccatgctgcggaatgggggcgcggggaacggaggtcagacctgcatg ctgcgctggtccaaccgcatccgcctcacgtggctcagcttcacgctctttgtcatcctg gtcttcttcccgctcatcgcccactattacctcaccactctggatgaggctgatgaggca ggcaagcggatttttggtccccgggtggggaacgagctgtgcgaggtgaagcacgtgctg gatctgtgccgcatccgggagtcggtgagtgaagagctcctgcagctggaggccaagcgc caagagctgaacagcgagatcgccaagctgaatctgaagatcgaagcctgtaagaagagc attgagaacgccaagcaggacctgctccagctcaagaatgtcatcagccagaccgagcat tcctacaaggagctcatggcccagaaccagcccaagctgtccctgcccatccgactgctc ccagagaaggacgatgccggcctccctcccccgaaggccactcggggctgccggctacac aactgctttgattattctcgttgccctctcacctctggcttcccggtctacgtctatgac agtgaccagtttgtctttggcagctacctggatcccttggtcaagcaggcttttcaggcg acagcacgagctaacgtttatgttacagaaaatgcagacatcgcctgcctttacgtgata ctagtgggagagatgcaggagcccgtggtgctgcggcctgctgagctggagaagcagttg tattccctgccacactggcggacggatggacacaaccatgtcatcatcaatctgtcacgt aagtcagatacacagaaccttctctataacgtcagtactggccgtgccatggtggcccag tccaccttctacactgtccagtacagacctggctttgacttggtcgtatcaccgctggtc catgccatgtctgagcccaacttcatggaaatcccaccacaggtgccggtgaagcggaaa tatctcttcaccttccagggcgagaagattgagtctctgaggtctagccttcaggaggcc cgctccttcgaagaggaaatggagggcgaccctcccgccgactacgatgaccggatcatt gccaccctgaaggcggtgcaggacagcaagctggatcaggtcctggtggaattcacctgc aaaaaccagcccaaacccagcctgccgactgagtgggcactgtgtggagagcgggaggac cgcttggaattgctgaagctctccaccttcgccctcatcattacccccggggaccctcgc ttggttatttcctctgggtgtgcaacacggctcttcgaagccctggaagtcggtgccgtc ccggtggtgctgggggagcaggtccagcttccctaccaggacatgctgcagtggaacgag gcggccctggtggtgccaaagcctcgtgttaccgaggttcatttcctgctcagaagcctc tccgatagtgacctcctggctatgaggcggcaaggccgctttctctgggagacttacttc tccactgctgacagtatttttaataccgtgctggctatgattaggactcgcatccagatc ccagccgctcccatccgggaagaggcggcagctgagatcccccaccgttcaggcaaggcg gctggaactgaccccaacatggctgacaacggggacctggacctggggccagtggagacg gagccgccctacgcctcacccagatacctccgcaatttcactctgactgtcactgacttt taccgcagctggaactgtgctccagggcctttccatcttttcccccacactccctttgac cctgtgttgccctcagaggccaaattcttgggctcagggactggctttcggcctattggt ggtggagctgggggttctggcaaggaatttcaggcagcgcttggaggcaatgttccccga gagcagttcacggtggtgatgttgacttatgagcgggaggaagtgcttatgaactcttta gagaggctgaatggcctcccttacctgaacaaggtcgtggtggtgtggaattctcccaag ctgccatcagaggaccttctgtggcctgacattggcgttcccatcatggtggtccgtact gagaagaacagtttgaacaaccgattcttaccctggaatgaaattgagacagaggccatc ctgtccattgatgacgatgctcacctccgccatgacgaaatcatgtttgggttccgggtg tggagagaagctcgggaccgcatcgtgggcttccctggccgttaccacgcatgggacatc ccccatcagtcctggctctacaactccaactactcctgtgagctgtccatggtgctgaca ggtgctgccttctttcacaagtattatgcctacctgtattcttatgtgatgccccaggcc atccgggacatggtggatgaatacatcaactgtgaggacattgccatgaacttccttgtc tcccacatcactcggaagccccccatcaaggtgacctcacggtggacattccgatgccca ggatgccctcaggccctgtctcatgatgactcccacttccacgagcggcacaagtgcatc aacttcttcgtgaaggtgtacggctacatgcccctcctgtacacgcagttcagggtggat tctgtgctcttcaagacacgcctgccccatgacaagaccaagtgcttcaagttcatctag |
Protein Sequence |
>2137 : length: 919 MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFPLIAHYYLTTLDEADEA GKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKIEACKKS IENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPKATRGCRLH NCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARANVYVTENADIACLYVI LVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQ STFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIESLRSSLQEA RSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCGERED RLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDMLQWNE AALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTRIQI PAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRNFTLTVTDF YRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPR EQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRT EKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDI PHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLV SHITRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVD SVLFKTRLPHDKTKCFKFI |