| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 2271 |
Name | FH |
Synonym | FMRD|HLRCC|LRCC|MCL|MCUL1;fumarate hydratase;FH;fumarate hydratase |
Definition | fumarase|fumarate hydratase, mitochondrial |
Position | 1q42.1 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 7214 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046 |
Pathway | TCA cycle;PANTHER;P00051 |
Pathway | Citrate cycle (TCA cycle);KEGG PATHWAY;hsa00020 |
Pathway | respiration (anaerobic);BioCyc;ANARESP1-PWY |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | TCA cycle variation III (eukaryotic);BioCyc;PWY-5690 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Disease | Cancers;KEGG DISEASE |
Disease | Ovarian disease;FunDO |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | Fumarase deficiency;OMIM |
Disease | Multiple cutaneous and uterine leiomyomata;OMIM |
Disease | Cancer;FunDO |
Disease | Leiomyomatosis and renal cell cancer;OMIM |
Disease | Testicular tumor;FunDO |
Disease | Renal cell carcinoma;KEGG DISEASE;H00021 |
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External Links |
|
Links to Entrez Gene | 2271 |
Links to all GeneRIF Items | 2271 |
Links to iHOP | 2271 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2271 : length: 1533 atgtaccgagcacttcggctcctcgcgcgctcgcgtcccctcgtgcgggctccagccgca gccttagcttcggctcccggcttgggtggcgcggccgtgccctcgttttggcctccgaac gcggctcgaatggcaagccaaaattccttccggatagaatatgatacctttggtgaacta aaggtgccaaatgataagtattatggcgcccagaccgtgagatctacgatgaactttaag attggaggtgtgacagaacgcatgccaaccccagttattaaagcttttggcatcttgaag cgagcggccgctgaagtaaaccaggattatggtcttgatccaaagattgctaatgcaata atgaaggcagcagatgaggtagctgaaggtaaattaaatgatcattttcctctcgtggta tggcagactggatcaggaactcagacaaatatgaatgtaaatgaagtcattagcaataga gcaattgaaatgttaggaggtgaacttggcagcaagatacctgtgcatcccaacgatcat gttaataaaagccagagctcaaatgatacttttcccacagcaatgcacattgctgctgca atagaagttcatgaagtactgttaccaggactacagaagttacatgatgctcttgatgca aaatccaaagagtttgcacagatcatcaagattggacgtactcatactcaggatgctgtt ccacttactcttgggcaggaatttagtggttatgttcaacaagtaaaatatgcaatgaca agaataaaagctgccatgccaagaatctatgagctcgcagctggaggcactgctgttggt acaggtttaaatactagaattggctttgcagaaaaggttgctgcaaaagtggctgcactt acaggcttgccttttgtcactgctccgaataaatttgaagctctggctgctcatgacgct ctggttgagctcagtggagccatgaacactactgcctgcagtctgatgaagatagcaaat gatattcgatttttgggttctggtcctcggtcaggtctgggagaattgatcttgcctgaa aatgaaccaggaagcagtatcatgccaggcaaggtgaaccctactcagtgtgaagcaatg accatggttgcagcccaagtcatggggaaccatgttgctgtcactgtcggaggcagcaat ggacattttgagttgaatgttttcaagccaatgatgattaaaaatgtgttacactcagcc aggctgctgggggatgcttcagtttcctttacagaaaactgcgtggtgggaatccaggcc aatacagaaaggatcaacaagctgatgaatgagtctctaatgttggtgacagctctcaat cctcatatagggtatgacaaggcagcaaagattgctaagacagcacacaaaaatggatca accttaaaggaaactgctatcgaacttggctatctcacagcagagcagtttgacgaatgg gtaaaacctaaggacatgctgggtccaaagtga |
Protein Sequence |
>2271 : length: 510 MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS TLKETAIELGYLTAEQFDEWVKPKDMLGPK |