| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2308 |
Name | FOXO1 |
Synonym | FKH1|FKHR|FOXO1A;forkhead box O1;FOXO1;forkhead box O1 |
Definition | forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma |
Position | 13q14.1 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 7350 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | AKT-mediated inactivation of FOXO1A;PID Reactome;500523 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Regulation of beta-cell development;Reactome;REACT:13698 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Regulation of gene expression in beta cells;PID Reactome;500522 |
Disease | Cancers;KEGG DISEASE |
Disease | Rhabdomyosarcoma, alveolar;OMIM |
Disease | Prostate cancer;FunDO |
Disease | Muscular atrophy;FunDO |
Disease | Cancers of soft tissues and bone;KEGG DISEASE |
Disease | Leukemia;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Alveolar rhabdomyosarcoma;KEGG DISEASE;H00037 |
Disease | Central corneal thickness;NHGRI |
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External Links |
|
Links to Entrez Gene | 2308 |
Links to all GeneRIF Items | 2308 |
Links to iHOP | 2308 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2308 : length: 1968 atggccgaggcgcctcaggtggtggagatcgacccggacttcgagccgctgccccggccg cgctcgtgcacctggccgctgcccaggccggagtttagccagtccaactcggccacctcc agcccggcgccgtcgggcagcgcggctgccaaccccgacgccgcggcgggcctgccctcg gcctcggctgccgctgtcagcgccgacttcatgagcaacctgagcttgctggaggagagc gaggacttcccgcaggcgcccggctccgtggcggcggcggtggcggcggcggccgccgcg gccgccaccggggggctgtgcggggacttccagggcccggaggcgggctgcctgcaccca gcgccaccgcagcccccgccgcccgggccgctgtcgcagcacccgccggtgccccccgcc gccgctgggccgctcgcggggcagccgcgcaagagcagctcgtcccgccgcaacgcgtgg ggcaacctgtcctacgccgacctcatcaccaaggccatcgagagctcggcggagaagcgg ctcacgctgtcgcagatctacgagtggatggtcaagagcgtgccctacttcaaggataag ggtgacagcaacagctcggcgggctggaagaattcaattcgtcataatctgtccctacac agcaagttcattcgtgtgcagaatgaaggaactggaaaaagttcttggtggatgctcaat ccagagggtggcaagagcgggaaatctcctaggagaagagctgcatccatggacaacaac agtaaatttgctaagagccgaagccgagctgccaagaagaaagcatctctccagtctggc caggagggtgctggggacagccctggatcacagttttccaaatggcctgcaagccctggc tctcacagcaatgatgactttgataactggagtacatttcgccctcgaactagctcaaat gctagtactattagtgggagactctcacccattatgaccgaacaggatgatcttggagaa ggggatgtgcattctatggtgtacccgccatctgccgcaaagatggcctctactttaccc agtctgtctgagataagcaatcccgaaaacatggaaaatcttttggataatctcaacctt ctctcatcaccaacatcattaactgtttcgacccagtcctcacctggcaccatgatgcag cagacgccgtgctactcgtttgcgccaccaaacaccagtttgaattcacccagcccaaac taccaaaaatatacatatggccaatccagcatgagccctttgccccagatgcctatacaa acacttcaggacaataagtcgagttatggaggtatgagtcagtataactgtgcgcctgga ctcttgaaggagttgctgacttctgactctcctccccataatgacattatgacaccagtt gatcctggggtagcccagcccaacagccgggttctgggccagaacgtcatgatgggccct aattcggtcatgtcaacctatggcagccaggcatctcataacaaaatgatgaatcccagc tcccatacccaccctggacatgctcagcagacatctgcagttaacgggcgtcccctgccc cacacggtaagcaccatgccccacacctcgggtatgaaccgcctgacccaagtgaagaca cctgtacaagtgcctctgccccaccccatgcagatgagtgccctggggggctactcctcc gtgagcagctgcaatggctatggcagaatgggccttctccaccaggagaagctcccaagt gacttggatggcatgttcattgagcgcttagactgtgacatggaatccatcattcggaat gacctcatggatggagatacattggattttaactttgacaatgtgttgcccaaccaaagc ttcccacacagtgtcaagacaacgacacatagctgggtgtcaggctga |
Protein Sequence |
>2308 : length: 655 MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPS ASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHP APPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKR LTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLN PEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPG SHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLP SLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPN YQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPV DPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLP HTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPS DLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG |