| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2309 |
Name | FOXO3 |
Synonym | AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A;forkhead box O3;FOXO3;forkhead box O3 |
Definition | forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 |
Position | 6q21 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 7351 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | the igf-1 receptor and longevity;PID BioCarta;100115 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis;PID BioCarta;100255 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Disease | Normalized brain volume;NHGRI |
Disease | IMMUNE;GAD |
Disease | normalized brain volume, multiple sclerosis;GAD |
|
External Links |
|
Links to Entrez Gene | 2309 |
Links to all GeneRIF Items | 2309 |
Links to iHOP | 2309 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2309 : length: 2022 atggcagaggcaccggcttccccggccccgctctctccgctcgaagtggagctggacccg gagttcgagccccagagccgtccgcgatcctgtacgtggcccctgcaaaggccggagctc caagcgagccctgccaagccctcgggggagacggccgccgactccatgatccccgaggag gaggacgatgaagacgacgaggacggcgggggacgggccggctcggccatggcgatcggc ggcggcggcgggagcggcacgctgggctccgggctgctccttgaggactcggcccgggtg ctggcacccggagggcaagaccccgggtctgggccagccaccgcggcgggcgggctgagc gggggtacacaggcgctgctgcagcctcagcaaccgctgccaccgccgcagccgggggcg gctgggggctccgggcagccgaggaaatgttcgtcgcggcggaacgcctggggaaacctg tcctacgcggacctgatcacccgcgccatcgagagctccccggacaaacggctcactctg tcccagatctacgagtggatggtgcgttgcgtgccctacttcaaggataagggcgacagc aacagctctgccggctggaagaactccatccggcacaacctgtcactgcatagtcgattc atgcgggtccagaatgagggaactggcaagagctcttggtggatcatcaaccctgatggg gggaagagcggaaaagccccccggcggcgggctgtctccatggacaatagcaacaagtat accaagagccgtggccgcgcagccaagaagaaggcagccctgcagacagcccccgaatca gctgacgacagtccctcccagctctccaagtggcctggcagccccacgtcacgcagcagt gatgagctggatgcgtggacggacttccgttcacgcaccaattctaacgccagcacagtc agtggccgcctgtcgcccatcatggcaagcacagagttggatgaagtccaggacgatgat gcgcctctctcgcccatgctctacagcagctcagccagcctgtcaccttcagtaagcaag ccgtgcacggtggaactgccacggctgactgatatggcaggcaccatgaatctgaatgat gggctgactgaaaacctcatggacgacctgctggataacatcacgctcccgccatcccag ccatcgcccactgggggactcatgcagcggagctctagcttcccgtataccaccaagggc tcgggcctgggctccccaaccagctcctttaacagcacggtgttcggaccttcatctctg aactccctacgccagtctcccatgcagaccatccaagagaacaagccagctaccttctct tccatgtcacactatggtaaccagacactccaggacctgctcacttcggactcacttagc cacagcgatgtcatgatgacacagtcggaccccttgatgtctcaggccagcaccgctgtg tctgcccagaattcccgccggaacgtgatgcttcgcaatgatccgatgatgtcctttgct gcccagcctaaccagggaagtttggtcaatcagaacttgctccaccaccagcaccaaacc cagggcgctcttggtggcagccgtgccttgtcgaattctgtcagcaacatgggcttgagt gagtccagcagccttgggtcagccaaacaccagcagcagtctcctgtcagccagtctatg caaaccctctcggactctctctcaggctcctccttgtactcaactagtgcaaacctgccc gtcatgggccatgagaagttccccagcgacttggacctggacatgttcaatgggagcttg gaatgtgacatggagtccattatccgtagtgaactcatggatgctgatgggttggatttt aactttgattccctcatctccacacagaatgttgttggtttgaacgtggggaacttcact ggtgctaagcaggcctcatctcagagctgggtgccaggctga |
Protein Sequence |
>2309 : length: 673 MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE EDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS GGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTL SQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDG GKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSS DELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSK PCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKG SGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLS HSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQT QGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLP VMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFT GAKQASSQSWVPG |