| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 27030 |
Name | MLH3 |
Synonym | HNPCC7;mutL homolog 3;MLH3;mutL homolog 3 |
Definition | DNA mismatch repair protein Mlh3 |
Position | 14q24.3 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 1864 |
TUSON P-value | 0.220988888 |
|
Pathways and Diseases |
|
Pathway | Mismatch repair;KEGG PATHWAY;hsa03430 |
Disease | Esophageal tumor;FunDO |
Disease | Colon cancer, hereditary nonpolyposis, type 7;OMIM |
Disease | head and neck cancer lung cancer;GAD |
Disease | Colorectal cancer, somatic;OMIM |
Disease | CANCER;GAD |
Disease | mammalian microsatellite instability;GAD |
Disease | Endometrial cancer;OMIM |
Disease | Colon cancer;FunDO |
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External Links |
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Links to Entrez Gene | 27030 |
Links to all GeneRIF Items | 27030 |
Links to iHOP | 27030 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>27030 : length: 4362 atgatcaagtgcttgtcagttgaagtacaagccaaattgcgttctggtttggccataagc tccttgggccaatgtgttgaggaacttgccctcaacagtattgatgctgaagcaaaatgt gtggctgtcagggtgaatatggaaaccttccaagttcaagtgatagacaatggatttggg atggggagtgatgatgtagagaaagtgggaaatcgttatttcaccagtaaatgccactcg gtacaggacttggagaatccaaggttttatggtttccgaggagaggccttggcaaatatt gctgacatggccagtgctgtggaaatttcgtccaagaaaaacaggacaatgaaaactttt gtgaaactgtttcagagtggaaaagccctgaaagcttgtgaagctgatgtgactagagca agcgctgggactactgtaacagtgtataacctattttaccagcttcctgtaaggaggaaa tgcatggaccctagactggagtttgagaaggttaggcagagaatagaagctctctcactc atgcacccttccatttctttctctttgagaaatgatgtttctggttccatggttcttcag ctccctaaaaccaaagacgtatgttcccgattttgtcaaatttatggattgggaaagtcc caaaagctaagagaaataagttttaaatataaagagtttgagcttagtggctatatcagc tctgaagcacattacaacaagaatatgcagtttttgtttgtgaacaaaagactagtttta aggacaaagctacataaactcattgactttttattaaggaaagaaagtattatatgcaag ccaaagaatggtcccaccagtaggcaaatgaattcaagtcttcggcaccggtctacccca gaactctatggcatatatgtaattaatgtgcagtgccaattctgtgagtatgatgtgtgc atggagccagccaaaactctgattgaatttcagaactgggacactctcttgttttgcatt caggaaggagtgaaaatgtttttaaagcaagaaaaattatttgtggaattatcaggtgag gatattaaggaatttagtgaagataatggttttagtttatttgatgctactcttcagaag cgtgtgacttccgatgagaggagcaatttccaggaagcatgtaataatattttagattcc tatgagatgtttaatttgcagtcaaaagctgtgaaaagaaaaactactgcagaaaacgta aacacacagagttctagggattcagaagctaccagaaaaaatacaaatgatgcatttttg tacatttatgaatcaggtggtccaggccatagcaaaatgacagagccatctttacaaaac aaagacagctcttgctcagaatcaaagatgttagaacaagagacaattgtagcatcagaa gctggagaaaatgagaaacataaaaaatctttcctggaacatagctctttagaaaatccg tgtggaaccagtttagaaatgtttttaagcccttttcagacaccatgtcactttgaggag agtgggcaggatctagaaatatggaaagaaagtactactgttaatggcatggctgccaac atcttgaaaaataatagaattcagaatcaaccaaagagatttaaagatgctactgaagtg ggatgccagcctctgccttttgcaacaacattatggggagtacatagtgctcagacagag aaagagaaaaaaaaagaatctagcaattgtggaagaagaaatgtttttagttatgggcga gttaaattatgttccactggctttataactcatgtagtacaaaatgaaaaaactaaatca actgaaacagaacattcatttaaaaattatgttagacctggtcccacacgtgcccaagaa acatttggaaatagaacacgtcattcagttgaaactccagacatcaaagatttagccagc actttaagtaaagaatctggtcaattgcccaacaaaaaaaattgcagaacgaatataagt tatgggctagagaatgaacctacagcaacttatacaatgttttctgcttttcaggaaggt agcaaaaaatcacaaacagattgcatattatctgatacatccccctctttcccctggtat agacacgtttccaatgatagtaggaaaacagataaattaattggtttctccaaaccaatc gtccgtaagaagctaagcttgagttcacagctaggatctttagagaagtttaagaggcaa tatgggaaggttgaaaatcctctggatacagaagtagaggaaagtaatggagtcactacc aatctcagtcttcaagttgaacctgacattctgctgaaggacaagaaccgcttagagaac tctgatgtttgtaaaatcactactatggagcatagtgattcagatagtagttgtcaacca gcaagccacatccttaactcagagaagtttccattctccaaggatgaagattgtttagaa caacagatgcctagtttgagagaaagtcctatgaccctgaaggagttatctctctttaat agaaaacctttggaccttgagaagtcatctgaatcactagcctctaaattatccagactg aagggttccgaaagagaaactcaaacaatggggatgatgagtcgttttaatgaacttcca aattcagattccagtaggaaagacagcaagttgtgcagtgtgttaacacaagatttttgt atgttatttaacaacaagcatgaaaaaacagagaatggtgtcatcccaacatcagattct gccacacaggataattcctttaataaaaatagtaaaacacattctaacagcaatacaaca gagaactgtgtgatatcagaaactcctttggtattgccctataataattctaaagttacc ggtaaagattcagatgttcttatcagagcctcagaacaacagataggaagtcttgactct cccagtggaatgttaatgaatccggtagaagatgccacaggtgaccaaaatggaatttgt tttcagagtgaggaatctaaagcaagagcttgttctgaaactgaagagtcaaacacgtgt tgttcagattggcagcggcatttcgatgtagccctgggaagaatggtttatgtcaacaaa atgactggactcagcacattcattgccccaactgaggacattcaggctgcttgtactaaa gacctgacaactgtggctgtggatgttgtacttgagaatgggtctcagtacaggtgtcaa ccttttagaagcgaccttgttcttcctttccttccgagagctcgagcagagaggactgtg atgagacaggataacagagatactgtggatgatactgttagtagcgaatcgcttcagtct ttgttctcagaatgggacaatccagtatttgcccgttatccagaggttgctgttgatgta agcagtggccaggctgagagcttagcagttaaaattcacaacatcttgtatccctatcgt ttcaccaaaggaatgattcattcaatgcaggttctccagcaagtagataacaagtttatt gcctgtttgatgagcactaagactgaagagaatggcgaggcaggtgggaacctgctcgtg ctggtggatcagcacgctgcccatgagcgtatacgtctggagcagcttatcattgattcc tacgagaagcaacaggcacaaggctctggtcggaaaaaattactgtcttctactctaatt cctccgctagagataacagtgacagaggaacaaaggagactcttatggtgttaccacaaa aatctggaagatctgggccttgaatttgtatttccagacactagtgattctctggtcctt gtgggaaaagtaccactatgttttgtggaaagagaagccaatgaacttcggagaggaaga tctactgtgaccaagagtattgtggaggaatttatccgagaacaactggagctactccag accaccggaggcatccaagggacattgccactgactgtccagaaggtgttggcatcccaa gcctgccatggggccattaagtttaatgatggcctgagcttacaggaaagttgccgcctt attgaagctctgtcctcatgccagctgccattccagtgtgctcacgggagaccttctatg ctgccgttagctgacatagaccacttggaacaggaaaaacagattaaacccaacctcact aaacttcgcaaaatggcccaggcctggcgtctctttggaaaagcagagtgtgatacaagg cagagcctgcagcaatccatgcctccctgtgagccaccatga |
Protein Sequence |
>27030 : length: 1453 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFG MGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTF VKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSL MHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYIS SEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTP ELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGE DIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENV NTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASE AGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAAN ILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGR VKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLAS TLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWY RHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTT NLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLE QQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELP NSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTT ENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGIC FQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTK DLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQS LFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFI ACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLI PPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGR STVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRL IEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTR QSLQQSMPPCEPP |