| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4771 |
Name | NF2 |
Synonym | ACN|BANF|SCH;neurofibromin 2 (merlin);NF2;neurofibromin 2 (merlin) |
Definition | merlin|moesin-ezrin-radixin like|moesin-ezrin-radixin-like protein|moesin-ezrin-radizin-like protein|neurofibromin 2 (bilateral acoustic neuroma)|neurofibromin-2|schwannomerlin|schwannomin |
Position | 22q12.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 85 |
TUSON P-value | 8.61E-07 |
|
Pathways and Diseases |
|
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Disease | Neurofibromatosis;FunDO |
Disease | Polyneuropathy;FunDO |
Disease | Cancers;KEGG DISEASE |
Disease | Schwannomatosis;OMIM |
Disease | Cancers of the lung and pleura;KEGG DISEASE |
Disease | neurofibromatosis2;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | Neurofibromatosis, type 2;OMIM |
Disease | Spinal cord disease;FunDO |
Disease | Cancer;FunDO |
Disease | Neurofibromatosis type 2;GAD |
Disease | Meningioma, NF2-related, somatic;OMIM |
Disease | Carotid atherosclerosis in HIV infection;GAD |
Disease | Malignant pleural mesothelioma;KEGG DISEASE;H00015 |
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External Links |
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Links to Entrez Gene | 4771 |
Links to all GeneRIF Items | 4771 |
Links to iHOP | 4771 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>4771 : length: 1788 atggccggggccatcgcttcccgcatgagcttcagctctctcaagaggaagcaacccaag acgttcaccgtgaggatcgtcaccatggacgccgagatggagttcaattgcgagatgaag tggaaagggaaggacctctttgatttggtgtgccggactctggggctccgagaaacctgg ttctttggactgcagtacacaatcaaggacacagtggcctggctcaaaatggacaagaag gtactggatcatgatgtttcaaaggaagaaccagtcacctttcacttcttggccaaattt tatcctgagaatgctgaagaggagctggttcaggagatcacacaacatttattcttctta caggtaaagaagcagattttagatgaaaagatctactgccctcctgaggcttctgtgctc ctggcttcttacgccgtccaggccaagtatggtgactacgaccccagtgttcacaagcgg ggatttttggcccaagaggaattgcttccaaaaagggtaataaatctgtatcagatgact ccggaaatgtgggaggagagaattactgcttggtacgcagagcaccgaggccgagccagg gatgaagctgaaatggaatatctgaagatagctcaggacctggagatgtacggtgtgaac tactttgcaatccggaataaaaagggcacagagctgctgcttggagtggatgccctgggg cttcacatttatgaccctgagaacagactgacccccaagatctccttcccgtggaatgaa atccgaaacatctcgtacagtgacaaggagtttactattaaaccactggataagaaaatt gatgtcttcaagtttaactcctcaaagcttcgtgttaataagctgattctccagctatgt atcgggaaccatgatctatttatgaggagaaggaaagccgattctttggaagttcagcag atgaaagcccaggccagggaggagaaggctagaaagcagatggagcggcagcgcctcgct cgagagaagcagatgagggaggaggctgaacgcacgagggatgagttggagaggaggctg ctgcagatgaaagaagaagcaacaatggccaacgaagcactgatgcggtctgaggagaca gctgacctgttggctgaaaaggcccagatcaccgaggaggaggcaaaacttctggcccag aaggccgcagaggctgagcaggaaatgcagcgcatcaaggccacagcgattcgcacggag gaggagaagcgcctgatggagcagaaggtgctggaagccgaggtgctggcactgaagatg gctgaggagtcagagaggagggccaaagaggcagatcagctgaagcaggacctgcaggaa gcacgcgaggcggagcgaagagccaagcagaagctcctggagattgccaccaagcccacg tacccgcccatgaacccaattccagcaccgttgcctcctgacataccaagcttcaacctc attggtgacagcctgtctttcgacttcaaagatactgacatgaagcggctttccatggag atagagaaagaaaaagtggaatacatggaaaagagcaagcatctgcaggagcagctcaat gaactcaagacagaaatcgaggccttgaaactgaaagagagggagacagctctggatatt ctgcacaatgagaactccgacaggggtggcagcagcaagcacaataccattaaaaagctc accttgcagagcgccaagtcccgagtggccttctttgaagagctctag |
Protein Sequence |
>4771 : length: 595 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL |