| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5071 |
Name | PARK2 |
Synonym | AR-JP|LPRS2|PDJ|PRKN;parkin RBR E3 ubiquitin protein ligase;PARK2;parkin RBR E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase parkin|Parkinson disease (autosomal recessive, juvenile) 2, parkin|parkinson juvenile disease protein 2|parkinson protein 2, E3 ubiquitin protein ligase (parkin) |
Position | 6q25.2-q27 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 12357 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease;PID BioCarta;100080 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | role of parkin in ubiquitin-proteasomal pathway;PID BioCarta;100081 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | Parkinson's disease;KEGG PATHWAY;hsa05012 |
Disease | Primary tumor;FunDO |
Disease | Serum metabolites;NHGRI |
Disease | Pancreatic cancer;NHGRI |
Disease | Nervous system diseases;KEGG DISEASE |
Disease | Breast cancer;FunDO |
Disease | Liver cancer;FunDO |
Disease | Leprosy, susceptibility to;OMIM |
Disease | Leprosy;FunDO |
Disease | Parkinson's disease;GAD |
Disease | Leprosy;GAD |
Disease | serum metabolites;GAD |
Disease | Leukemia;FunDO |
Disease | METABOLIC;GAD |
Disease | INFECTION;GAD |
Disease | Adenocarcinoma of lung, somatic;OMIM |
Disease | Tuberculosis;FunDO |
Disease | Adenocarcinoma, ovarian, somatic;OMIM |
Disease | Movement disorder;FunDO |
Disease | CNS metastases;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | Parkinson's disease;KEGG DISEASE;H00057 |
Disease | Parkinson disease, juvenile, type 2;OMIM |
Disease | Ovarian cancer;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Neurodegenerative diseases;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 5071 |
Links to all GeneRIF Items | 5071 |
Links to iHOP | 5071 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5071 : length: 1398 atgatagtgtttgtcaggttcaactccagccatggtttcccagtggaggtcgattctgac accagcatcttccagctcaaggaggtggttgctaagcgacagggggttccggctgaccag ttgcgtgtgattttcgcagggaaggagctgaggaatgactggactgtgcagaattgtgac ctggatcagcagagcattgttcacattgtgcagagaccgtggagaaaaggtcaagaaatg aatgcaactggaggcgacgaccccagaaacgcggcgggaggctgtgagcgggagccccag agcttgactcgggtggacctcagcagctcagtcctcccaggagactctgtggggctggct gtcattctgcacactgacagcaggaaggactcaccaccagctggaagtccagcaggtaga tcaatctacaacagcttttatgtgtattgcaaaggcccctgtcaaagagtgcagccggga aaactcagggtacagtgcagcacctgcaggcaggcaacgctcaccttgacccagggtcca tcttgctgggatgatgttttaattccaaaccggatgagtggtgaatgccaatccccacac tgccctgggactagtgcagaatttttctttaaatgtggagcacaccccacctctgacaag gaaacatcagtagctttgcacctgatcgcaacaaatagtcggaacatcacttgcattacg tgcacagacgtcaggagccccgtcctggttttccagtgcaactcccgccacgtgatttgc ttagactgtttccacttatactgtgtgacaagactcaatgatcggcagtttgttcacgac cctcaacttggctactccctgccttgtgtggctggctgtcccaactccttgattaaagag ctccatcacttcaggattctgggagaagagcagtacaaccggtaccagcagtatggtgca gaggagtgtgtcctgcagatggggggcgtgttatgcccccgccctggctgtggagcgggg ctgctgccggagcctgaccagaggaaagtcacctgcgaagggggcaatggcctgggctgt gggtttgccttctgccgggaatgtaaagaagcgtaccatgaaggggagtgcagtgccgta tttgaagcctcaggaacaactactcaggcctacagagtcgatgaaagagccgccgagcag gctcgttgggaagcagcctccaaagaaaccatcaagaaaaccaccaagccctgtccccgc tgccatgtaccagtggaaaaaaatggaggctgcatgcacatgaagtgtccgcagccccag tgcaggctcgagtggtgctggaactgtggctgcgagtggaaccgcgtctgcatgggggac cactggttcgacgtgtag |
Protein Sequence |
>5071 : length: 465 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV |