| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8930 |
Name | MBD4 |
Synonym | MED1;methyl-CpG binding domain protein 4;MBD4;methyl-CpG binding domain protein 4 |
Definition | 3,N(4)-ethenocytosine glycosylase|G/5-fluorouracil mismatch glycosylase with biphasic kinetics|G/T mismatch glycosylase|G/U mismatch glycosylase|methyl-CpG-binding domain protein 4|methyl-CpG-binding endonuclease 1|methyl-CpG-binding protein MBD4|mismatch |
Position | 3q21.3 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 10364 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Base excision repair;KEGG PATHWAY;hsa03410 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | Depyrimidination;PID Reactome;500031 |
Pathway | Cleavage of the damaged pyrimidine;PID Reactome;501015 |
Pathway | Recognition and association of DNA glycosylase with site containing an affected pyrimidine;PID Reactome;500926 |
Pathway | Displacement of DNA glycosylase by APE1;PID Reactome;501000 |
Disease | lung cancer;GAD |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
|
External Links |
|
Links to Entrez Gene | 8930 |
Links to all GeneRIF Items | 8930 |
Links to iHOP | 8930 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>8930 : length: 1743 atgggcacgactgggctggagagtctgagtctgggggaccgcggagctgcccccaccgtc acctctagtgagcgcctagtcccagacccgccgaatgacctccgcaaagaagatgttgct atggaattggaaagagtgggagaagatgaggaacaaatgatgataaaaagaagcagtgaa tgtaatcccttgctacaagaacccatcgcttctgctcagtttggtgctactgcaggaaca gaatgccgtaagtctgtcccatgtggatgggaaagagttgtgaagcaaaggttatttggg aagacagcaggaagatttgatgtgtactttatcagcccacaaggactgaagttcagatcc aaaagttcacttgctaattatcttcacaaaaatggagagacttctcttaagccagaagat tttgattttactgtactttctaaaaggggtatcaagtcaagatataaagactgcagcatg gcagccctgacatcccatctacaaaaccaaagtaacaattcaaactggaacctcaggacc cgaagcaagtgcaaaaaggatgtgtttatgccgccaagtagtagttcagagttgcaggag agcagaggactctctaactttacttccactcatttgcttttgaaagaagatgagggtgtt gatgatgttaacttcagaaaggttagaaagcccaaaggaaaggtgactattttgaaagga atcccaattaagaaaactaaaaaaggatgtaggaagagctgttcaggttttgttcaaagt gatagcaaaagagaatctgtgtgtaataaagcagatgctgaaagtgaacctgttgcacaa aaaagtcagcttgatagaactgtctgcatttctgatgctggagcatgtggtgagaccctc agtgtgaccagtgaagaaaacagccttgtaaaaaaaaaagaaagatcattgagttcagga tcaaatttttgttctgaacaaaaaacttctggcatcataaacaaattttgttcagccaaa gactcagaacacaacgagaagtatgaggatacctttttagaatctgaagaaatcggaaca aaagtagaagttgtggaaaggaaagaacatttgcatactgacattttaaaacgtggctct gaaatggacaacaactgctcaccaaccaggaaagacttcactggtgagaaaatatttcaa gaagataccatcccacgaacacagatagaaagaaggaaaacaagcctgtatttttccagc aaatataacaaagaagctcttagccccccacgacgtaaagcctttaagaaatggacacct cctcggtcaccttttaatctcgttcaagaaacactttttcatgatccatggaagcttctc atcgctactatatttctcaatcggacctcaggcaaaatggcaatacctgtgctttggaag tttctggagaagtatccttcagctgaggtagcaagaaccgcagactggagagatgtgtca gaacttcttaaacctcttggtctctacgatcttcgggcaaaaaccattgtcaagttctca gatgaatacctgacaaagcagtggaagtatccaattgagcttcatgggattggtaaatat ggcaacgactcttaccgaattttttgtgtcaatgagtggaagcaggtgcaccctgaagac cacaaattaaataaatatcatgactggctttgggaaaatcatgaaaaattaagtctatct taa |
Protein Sequence |
>8930 : length: 580 MGTTGLESLSLGDRGAAPTVTSSERLVPDPPNDLRKEDVAMELERVGEDEEQMMIKRSSE CNPLLQEPIASAQFGATAGTECRKSVPCGWERVVKQRLFGKTAGRFDVYFISPQGLKFRS KSSLANYLHKNGETSLKPEDFDFTVLSKRGIKSRYKDCSMAALTSHLQNQSNNSNWNLRT RSKCKKDVFMPPSSSSELQESRGLSNFTSTHLLLKEDEGVDDVNFRKVRKPKGKVTILKG IPIKKTKKGCRKSCSGFVQSDSKRESVCNKADAESEPVAQKSQLDRTVCISDAGACGETL SVTSEENSLVKKKERSLSSGSNFCSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGT KVEVVERKEHLHTDILKRGSEMDNNCSPTRKDFTGEKIFQEDTIPRTQIERRKTSLYFSS KYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWK FLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKY GNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS |