Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1026

Name

CDKN1A

Synonymous

CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1;cyclin-dependent kinase inhibitor 1A (p21, Cip1);CDKN1A;cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Definition

CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1

Position

6p21.2

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 AKT2NCI_NATURE;

in same component

 CDK2NCI_NATURE;

interacts with

 AKT1HPRD;

interacts with

 BCCIPBIOGRID;

interacts with

 BCCIPHPRD;

interacts with

 C1orf123HPRD;

interacts with

 CASP3HPRD;

interacts with

 CCDC85BBIOGRID;

interacts with

 CCDC85BHPRD;

interacts with

 CCNA1MINT;

interacts with

 CCNA2BIOGRID;

interacts with

 CCNA2HPRD;

interacts with

 CCNB1BIOGRID;

interacts with

 CCNB1HPRD;

interacts with

 CCNB1MINT;

interacts with

 CCNB2HPRD;

interacts with

 CCNB2MINT;

interacts with

 CCND1BIOGRID;

interacts with

 CCND1HPRD;

interacts with

 CCND1MINT;

interacts with

 CCND2BIOGRID;

interacts with

 CCND2HPRD;

interacts with

 CCND2MINT;

interacts with

 CCND3BIOGRID;

interacts with

 CCND3HPRD;

interacts with

 CCND3MINT;

interacts with

 CCNE1BIOGRID;

interacts with

 CCNE1HPRD;

interacts with

 CCNE1MINT;

interacts with

 CCNE2HPRD;

interacts with

 CDC20BIOGRID;

interacts with

 CDC20HPRD;

interacts with

 CDC27BIOGRID;

interacts with

 CDC27HPRD;

interacts with

 CDC45HPRD;

interacts with

 CDC45MINT;

interacts with

 CDC5LHPRD;

interacts with

 CDC6HPRD;

interacts with

 CDC6MINT;

interacts with

 CDC7HPRD;

interacts with

 CDC7MINT;

interacts with

 CDK14HPRD;

interacts with

 CDK1BIOGRID;

interacts with

 CDK2BIOGRID;

interacts with

 CDK2CELL_MAP;

interacts with

 CDK2HPRD;

interacts with

 CDK2MINT;

interacts with

 CDK3HPRD;

interacts with

 CDK4BIOGRID;

interacts with

 CDK4HPRD;

interacts with

 CDK4MINT;

interacts with

 CDK6BIOGRID;

interacts with

 CDK6HPRD;

interacts with

 CDK6MINT;

interacts with

 CEBPAHPRD;

interacts with

 CHEK1BIOGRID;

interacts with

 CIZ1BIOGRID;

interacts with

 CIZ1HPRD;

interacts with

 CREBBPBIOGRID;

interacts with

 CSNK2A1HPRD;

interacts with

 CSNK2BBIOGRID;

interacts with

 CSNK2BHPRD;

interacts with

 CUL4ABIOGRID;

interacts with

 DAPK3HPRD;

interacts with

 DDB1BIOGRID;

interacts with

 DHX9HPRD;

interacts with

 DTLBIOGRID;

interacts with

 E2F1BIOGRID;

interacts with

 EP300BIOGRID;

interacts with

 ESR1BIOGRID;

interacts with

 ESR1HPRD;

interacts with

 GADD45ABIOGRID;

interacts with

 GADD45BHPRD;

interacts with

 GADD45GBIOGRID;

interacts with

 GADD45GHPRD;

interacts with

 GAPDHBIOGRID;

interacts with

 GET4BIOGRID;

interacts with

 GET4HPRD;

interacts with

 GMNNHPRD;

interacts with

 GMNNMINT;

interacts with

 HAUS1MINT;

interacts with

 HDAC11BIOGRID;

interacts with

 HDAC11HPRD;

interacts with

 HDAC1BIOGRID;

interacts with

 HDAC2BIOGRID;

interacts with

 HDAC4BIOGRID;

interacts with

 HDAC6BIOGRID;

interacts with

 HERC5BIOGRID;

interacts with

 ITGB1BP3HPRD;

interacts with

 JUNBIOGRID;

interacts with

 MAP3K5BIOGRID;

interacts with

 MAP3K5HPRD;

interacts with

 MAPK8BIOGRID;

interacts with

 MAPK8HPRD;

interacts with

 MCM10HPRD;

interacts with

 MCM7MINT;

interacts with

 MDM2BIOGRID;

interacts with

 MDM2HPRD;

interacts with

 MDM4BIOGRID;

interacts with

 MKRN1MINT;

interacts with

 OBFC2BINTACT;

interacts with

 PARP1BIOGRID;

interacts with

 PARP1HPRD;

interacts with

 PCNABIOGRID;

interacts with

 PCNAHPRD;

interacts with

 PIM1BIOGRID;

interacts with

 PIM1HPRD;

interacts with

 PRKCHHPRD;

interacts with

 PSMA3BIOGRID;

interacts with

 PSMA3HPRD;

interacts with

 PSMC5BIOGRID;

interacts with

 PSMD2BIOGRID;

interacts with

 PSME3BIOGRID;

interacts with

 RAB1ABIOGRID;

interacts with

 RAB1AHPRD;

interacts with

 RB1HPRD;

interacts with

 RNF144BBIOGRID;

interacts with

 RNF144BHPRD;

interacts with

 RPA1HPRD;

interacts with

 SETBIOGRID;

interacts with

 SETHPRD;

interacts with

 SKP1MINT;

interacts with

 SKP2BIOGRID;

interacts with

 SKP2HPRD;

interacts with

 SKP2MINT;

interacts with

 SLC25A11HPRD;

interacts with

 STAT3BIOGRID;

interacts with

 STAT3HPRD;

interacts with

 TEX11BIOGRID;

interacts with

 TEX11HPRD;

interacts with

 TK1BIOGRID;

interacts with

 TK1HPRD;

interacts with

 TOP1HPRD;

interacts with

 TP53BIOGRID;

interacts with

 TP53MINT;

interacts with

 TSG101BIOGRID;

interacts with

 TSG101HPRD;

interacts with

 Tsg101MINT;

interacts with

 TTLL5HPRD;

interacts with

 XRCC6HPRD;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 ANGPT2NCI_NATURE;

metabolic catalysis

 DNMT3ANCI_NATURE;

metabolic catalysis

 E2F1NCI_NATURE;

metabolic catalysis

 EP300NCI_NATURE;

metabolic catalysis

 FOXG1NCI_NATURE;

metabolic catalysis

 GFI1NCI_NATURE;

metabolic catalysis

 HBP1NCI_NATURE;

metabolic catalysis

 HDAC2NCI_NATURE;

metabolic catalysis

 MAXNCI_NATURE;

metabolic catalysis

 MITFNCI_NATURE;

metabolic catalysis

 MYCNCI_NATURE;

metabolic catalysis

 NOC2LNCI_NATURE;

metabolic catalysis

 NOTCH1NCI_NATURE;

metabolic catalysis

 POU4F1NCI_NATURE;

metabolic catalysis

 RB1NCI_NATURE;

metabolic catalysis

 RBPJNCI_NATURE;

metabolic catalysis

 SIRT1NCI_NATURE;

metabolic catalysis

 SMAD4NCI_NATURE;

metabolic catalysis

 SMARCA4NCI_NATURE;

metabolic catalysis

 SMARCB1NCI_NATURE;

metabolic catalysis

 SP1NCI_NATURE;

metabolic catalysis

 SSRP1NCI_NATURE;

metabolic catalysis

 STAT5ANCI_NATURE;

metabolic catalysis

 TADA2BNCI_NATURE;

metabolic catalysis

 TAF9NCI_NATURE;

metabolic catalysis

 TEKNCI_NATURE;

metabolic catalysis

 TP53NCI_NATURE;

metabolic catalysis

 TP53REACTOME;

metabolic catalysis

 ZBTB17NCI_NATURE;

metabolic catalysis

 ZNF385ANCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 AKT2NCI_NATURE;

reacts with

 CDK2NCI_NATURE;

reacts with

 CDKN1ANCI_NATURE;

state change

 AKT1NCI_NATURE;

state change

 PTP4A1NCI_NATURE;

state change

 PTP4A2NCI_NATURE;

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