Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4087

Name

SMAD2

Synonymous

JV18|JV18-1|MADH2|MADR2|hMAD-2|hSMAD2;SMAD family member 2;SMAD2;SMAD family member 2

Definition

MAD homolog 2|SMAD, mothers against DPP homolog 2|Sma- and Mad-related protein 2|mother against DPP homolog 2|mothers against decapentaplegic homolog 2

Position

18q21.1

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 DCP1ANCI_NATURE;

in same component

 DYNLRB1NCI_NATURE;

in same component

 FOXH1NCI_NATURE;

in same component

 HDAC1NCI_NATURE;

in same component

 HDAC2NCI_NATURE;

in same component

 NCOR1NCI_NATURE;

in same component

 NEDD4LNCI_NATURE;

in same component

 NKX2-5NCI_NATURE;

in same component

 RBBP4NCI_NATURE;

in same component

 RBBP7NCI_NATURE;

in same component

 SAP18NCI_NATURE;

in same component

 SAP30NCI_NATURE;

in same component

 SIN3ANCI_NATURE;

in same component

 SIN3BNCI_NATURE;

in same component

 SKILNCI_NATURE;

in same component

 SMAD4CELL_MAP;

in same component

 SMAD4NCI_NATURE;

in same component

 SMURF2NCI_NATURE;

in same component

 TGFBR1NCI_NATURE;

in same component

 TGFBR2NCI_NATURE;

interacts with

 ABTB1HPRD;

interacts with

 ABTB1MINT;

interacts with

 ACVR1BBIOGRID;

interacts with

 ACVR1BHPRD;

interacts with

 AKT1BIOGRID;

interacts with

 AKT1HPRD;

interacts with

 ANAPC10BIOGRID;

interacts with

 ANAPC10HPRD;

interacts with

 ANAPC2HPRD;

interacts with

 ANAPC2MINT;

interacts with

 ANTXR2HPRD;

interacts with

 ANTXR2MINT;

interacts with

 ARFGAP3HPRD;

interacts with

 Arhgef1BIOGRID;

interacts with

 Arhgef6BIOGRID;

interacts with

 ARHGEF6HPRD;

interacts with

 Arhgef7BIOGRID;

interacts with

 ARID1ABIOGRID;

interacts with

 ARL4DHPRD;

interacts with

 ATF3BIOGRID;

interacts with

 Axin1CELL_MAP;

interacts with

 AXIN1HPRD;

interacts with

 BAZ1AHPRD;

interacts with

 BAZ1AMINT;

interacts with

 BPTFBIOGRID;

interacts with

 BRCA2BIOGRID;

interacts with

 BTBD2HPRD;

interacts with

 BTBD2MINT;

interacts with

 C22orf46HPRD;

interacts with

 CAMK2GBIOGRID;

interacts with

 CAV1BIOGRID;

interacts with

 CDC16BIOGRID;

interacts with

 CDC16CELL_MAP;

interacts with

 CDC16HPRD;

interacts with

 CDC27BIOGRID;

interacts with

 CDC27CELL_MAP;

interacts with

 CDC27HPRD;

interacts with

 Cdc40BIOGRID;

interacts with

 CDC40HPRD;

interacts with

 CDK4HPRD;

interacts with

 CISHHPRD;

interacts with

 CISHMINT;

interacts with

 CITED2BIOGRID;

interacts with

 COPS5HPRD;

interacts with

 COPS5MINT;

interacts with

 CREBBPBIOGRID;

interacts with

 CREBBPHPRD;

interacts with

 CREBBPMINT;

interacts with

 CSH1HPRD;

interacts with

 CSH1MINT;

interacts with

 CTNNB1BIOGRID;

interacts with

 CTNNB1CELL_MAP;

interacts with

 CTNNB1HPRD;

interacts with

 CUL5HPRD;

interacts with

 CUL5MINT;

interacts with

 CYP11A1HPRD;

interacts with

 CYP11A1MINT;

interacts with

 DAB2BIOGRID;

interacts with

 DAB2CELL_MAP;

interacts with

 DAB2HPRD;

interacts with

 DCAF6HPRD;

interacts with

 DCUN1D1HPRD;

interacts with

 DCUN1D1MINT;

interacts with

 DNAJC7HPRD;

interacts with

 DNAJC7MINT;

interacts with

 DOCK8MINT;

interacts with

 DVL1BIOGRID;

interacts with

 DVL1HPRD;

interacts with

 DYNC1H1HPRD;

interacts with

 E2F4HPRD;

interacts with

 EEF1A1HPRD;

interacts with

 EEF1A1MINT;

interacts with

 EID2BIOGRID;

interacts with

 EID2CELL_MAP;

interacts with

 EID2HPRD;

interacts with

 EIF3LHPRD;

interacts with

 EIF3LMINT;

interacts with

 EP300BIOGRID;

interacts with

 EP300CELL_MAP;

interacts with

 EP300HPRD;

interacts with

 ERBB2IPBIOGRID;

interacts with

 ERBB2IPHPRD;

interacts with

 ESR1BIOGRID;

interacts with

 ESR1CELL_MAP;

interacts with

 ESR1HPRD;

interacts with

 ESR2HPRD;

interacts with

 FAM161BMINT;

interacts with

 FBN2HPRD;

interacts with

 Fbxo3BIOGRID;

interacts with

 FOXG1HPRD;

interacts with

 FOXH1BIOGRID;

interacts with

 FOXH1CELL_MAP;

interacts with

 FOXH1HPRD;

interacts with

 FOXO3CELL_MAP;

interacts with

 FOXO3HPRD;

interacts with

 GATAD2BHPRD;

interacts with

 GATAD2BMINT;

interacts with

 GLI3HPRD;

interacts with

 GRIPAP1HPRD;

interacts with

 GSCHPRD;

interacts with

 GTF2IRD1BIOGRID;

interacts with

 GTF2IBIOGRID;

interacts with

 GTF2IHPRD;

interacts with

 HDAC1BIOGRID;

interacts with

 HDAC1CELL_MAP;

interacts with

 HGSHPRD;

interacts with

 HIPK2BIOGRID;

interacts with

 HIPK2HPRD;

interacts with

 HNF4AHPRD;

interacts with

 HOXA13HPRD;

interacts with

 HOXA9HPRD;

interacts with

 HOXD13HPRD;

interacts with

 HUWE1HPRD;

interacts with

 ING2BIOGRID;

interacts with

 INSRBIOGRID;

interacts with

 INSRHPRD;

interacts with

 Irak2BIOGRID;

interacts with

 IRAK2HPRD;

interacts with

 JUNBIOGRID;

interacts with

 JUNHPRD;

interacts with

 KAT2ABIOGRID;

interacts with

 KAT2BBIOGRID;

interacts with

 KAT2BCELL_MAP;

interacts with

 KAT2BHPRD;

interacts with

 KDM6BBIOGRID;

interacts with

 KHDRBS1HPRD;

interacts with

 KHDRBS1MINT;

interacts with

 KIAA1033MINT;

interacts with

 KPNB1HPRD;

interacts with

 KPNB1MINT;

interacts with

 LAMA5HPRD;

interacts with

 LAMA5MINT;

interacts with

 LEF1BIOGRID;

interacts with

 LEF1CELL_MAP;

interacts with

 LEMD3HPRD;

interacts with

 Lhx9BIOGRID;

interacts with

 LHX9HPRD;

interacts with

 Lhx9MINT;

interacts with

 LITAFHPRD;

interacts with

 Lmo2BIOGRID;

interacts with

 LMO2HPRD;

interacts with

 Map2k3BIOGRID;

interacts with

 MAPK1HPRD;

interacts with

 MAPK3HPRD;

interacts with

 MAPK8HPRD;

interacts with

 MAPK9HPRD;

interacts with

 MECOMBIOGRID;

interacts with

 MED15BIOGRID;

interacts with

 MED15HPRD;

interacts with

 MED15MINT;

interacts with

 MED24BIOGRID;

interacts with

 MED24MINT;

interacts with

 MED6BIOGRID;

interacts with

 MED6HPRD;

interacts with

 MED6MINT;

interacts with

 MEF2ABIOGRID;

interacts with

 MEF2AHPRD;

interacts with

 MEF2CBIOGRID;

interacts with

 MEF2CHPRD;

interacts with

 MLLT4MINT;

interacts with

 MYCBIOGRID;

interacts with

 MYCCELL_MAP;

interacts with

 MYCHPRD;

interacts with

 MYOCDBIOGRID;

interacts with

 NAGKHPRD;

interacts with

 NAGKMINT;

interacts with

 NCOA3BIOGRID;

interacts with

 NCOA6HPRD;

interacts with

 NCOA6MINT;

interacts with

 NEDD4LMINT;

interacts with

 NEDD4BIOGRID;

interacts with

 NEDD9BIOGRID;

interacts with

 NEDD9HPRD;

interacts with

 NF1BIOGRID;

interacts with

 NFYCBIOGRID;

interacts with

 NOTCH4HPRD;

interacts with

 Nuak2BIOGRID;

interacts with

 NUAK2HPRD;

interacts with

 NUP153CELL_MAP;

interacts with

 NUP153HPRD;

interacts with

 NUP214CELL_MAP;

interacts with

 NUP214HPRD;

interacts with

 OLIG1MINT;

interacts with

 OS9MINT;

interacts with

 PAK1HPRD;

interacts with

 PAPOLAHPRD;

interacts with

 PAPOLAMINT;

interacts with

 PAPPAHPRD;

interacts with

 PARD3BBIOGRID;

interacts with

 PAXIP1MINT;

interacts with

 PEX19HPRD;

interacts with

 PEX19MINT;

interacts with

 PIAS3BIOGRID;

interacts with

 PIAS3HPRD;

interacts with

 PIAS4BIOGRID;

interacts with

 PIAS4HPRD;

interacts with

 PIN1BIOGRID;

interacts with

 PKHD1HPRD;

interacts with

 PLIN3HPRD;

interacts with

 PLIN3MINT;

interacts with

 POU2AF1BIOGRID;

interacts with

 PPM1AHPRD;

interacts with

 PPP2R1AMINT;

interacts with

 Ppp2r2dBIOGRID;

interacts with

 PRDM16BIOGRID;

interacts with

 PRKAR1AHPRD;

interacts with

 PRKAR1AMINT;

interacts with

 PSAPHPRD;

interacts with

 PSAPMINT;

interacts with

 PSG9HPRD;

interacts with

 PSMD11HPRD;

interacts with

 PSMD11MINT;

interacts with

 PSMD8HPRD;

interacts with

 PSMD8MINT;

interacts with

 Rab34BIOGRID;

interacts with

 RAB34HPRD;

interacts with

 Rab38BIOGRID;

interacts with

 RAB38HPRD;

interacts with

 RANBP6MINT;

interacts with

 RANBP9HPRD;

interacts with

 RANBP9MINT;

interacts with

 RANHPRD;

interacts with

 RARBMINT;

interacts with

 Rasd2BIOGRID;

interacts with

 RASD2HPRD;

interacts with

 RASL12HPRD;

interacts with

 RBL1HPRD;

interacts with

 Rgs3BIOGRID;

interacts with

 Rhebl1BIOGRID;

interacts with

 RHEBL1HPRD;

interacts with

 Rhebl1MINT;

interacts with

 Rhobtb1BIOGRID;

interacts with

 RhodBIOGRID;

interacts with

 RHODHPRD;

interacts with

 RhodMINT;

interacts with

 RhojBIOGRID;

interacts with

 RHOJHPRD;

interacts with

 RIT1HPRD;

interacts with

 Rnf111BIOGRID;

interacts with

 RNF111BIOGRID;

interacts with

 RNF123HPRD;

interacts with

 RNF123MINT;

interacts with

 RNPC3MINT;

interacts with

 ROCK1HPRD;

interacts with

 ROCK1MINT;

interacts with

 RUNX2BIOGRID;

interacts with

 RUNX2CELL_MAP;

interacts with

 RUNX2HPRD;

interacts with

 RUNX3BIOGRID;

interacts with

 RXRAMINT;

interacts with

 Sip1BIOGRID;

interacts with

 SKILBIOGRID;

interacts with

 SKILCELL_MAP;

interacts with

 SKILHPRD;

interacts with

 SKILMINT;

interacts with

 SKIBIOGRID;

interacts with

 SKICELL_MAP;

interacts with

 SKIHPRD;

interacts with

 Smad2BIOGRID;

interacts with

 SMAD4BIOGRID;

interacts with

 SMAD4CELL_MAP;

interacts with

 SMAD4HPRD;

interacts with

 SMAD4MINT;

interacts with

 SMAD6BIOGRID;

interacts with

 SMAD7BIOGRID;

interacts with

 SMAD9HPRD;

interacts with

 SMAD9MINT;

interacts with

 SMARCA4BIOGRID;

interacts with

 SMARCC1BIOGRID;

interacts with

 SMURF1BIOGRID;

interacts with

 SMURF1MINT;

interacts with

 SMURF2BIOGRID;

interacts with

 SMURF2HPRD;

interacts with

 SMURF2MINT;

interacts with

 SNAPINHPRD;

interacts with

 SNAPINMINT;

interacts with

 SNIP1BIOGRID;

interacts with

 SNIP1CELL_MAP;

interacts with

 SNIP1HPRD;

interacts with

 SNRNP70HPRD;

interacts with

 SNRNP70MINT;

interacts with

 SNW1BIOGRID;

interacts with

 SNW1CELL_MAP;

interacts with

 SNW1HPRD;

interacts with

 SOX9BIOGRID;

interacts with

 SP1BIOGRID;

interacts with

 SP1CELL_MAP;

interacts with

 SP1HPRD;

interacts with

 Sqstm1BIOGRID;

interacts with

 SQSTM1HPRD;

interacts with

 SRIHPRD;

interacts with

 SRIMINT;

interacts with

 ST13HPRD;

interacts with

 ST13MINT;

interacts with

 ST5HPRD;

interacts with

 ST5MINT;

interacts with

 STAG1HPRD;

interacts with

 STAMBPL1CELL_MAP;

interacts with

 STAMBPL1HPRD;

interacts with

 STAMBPHPRD;

interacts with

 STRAPBIOGRID;

interacts with

 STRAPCELL_MAP;

interacts with

 STRAPHPRD;

interacts with

 STUB1HPRD;

interacts with

 TBC1D1MINT;

interacts with

 TGFB1BIOGRID;

interacts with

 TGFBR1BIOGRID;

interacts with

 TGFBR1MINT;

interacts with

 TGFBRAP1HPRD;

interacts with

 TGIF1BIOGRID;

interacts with

 TGIF1CELL_MAP;

interacts with

 TGIF1HPRD;

interacts with

 TGM2HPRD;

interacts with

 TGM2MINT;

interacts with

 TNNT1HPRD;

interacts with

 TOB1HPRD;

interacts with

 TP53CELL_MAP;

interacts with

 TP73CELL_MAP;

interacts with

 TP73HPRD;

interacts with

 TRIM33BIOGRID;

interacts with

 TRIM33HPRD;

interacts with

 Trim35BIOGRID;

interacts with

 TRIM62HPRD;

interacts with

 TRIM62MINT;

interacts with

 TSC2HPRD;

interacts with

 Uba52BIOGRID;

interacts with

 UBR5HPRD;

interacts with

 UBR5MINT;

interacts with

 UCHL5BIOGRID;

interacts with

 Uhmk1BIOGRID;

interacts with

 WWP1BIOGRID;

interacts with

 Wwp2BIOGRID;

interacts with

 WWP2INTACT;

interacts with

 YY1BIOGRID;

interacts with

 ZEB1BIOGRID;

interacts with

 ZEB1CELL_MAP;

interacts with

 ZEB1HPRD;

interacts with

 ZEB2HPRD;

interacts with

 ZEB2MINT;

interacts with

 ZFYVE9BIOGRID;

interacts with

 ZFYVE9CELL_MAP;

interacts with

 ZFYVE9HPRD;

interacts with

 ZFYVE9MINT;

interacts with

 ZMYND11MINT;

interacts with

 ZNF41HPRD;

interacts with

 ZNF41MINT;

interacts with

 ZNHIT6HPRD;

interacts with

 ZNHIT6MINT;

Metabolic Interaction   [Top]

There is no record for SMAD2

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 DCP1ANCI_NATURE;

reacts with

 DYNLRB1NCI_NATURE;

reacts with

 FOXH1NCI_NATURE;

reacts with

 HDAC1NCI_NATURE;

reacts with

 HDAC2NCI_NATURE;

reacts with

 NCOR1NCI_NATURE;

reacts with

 NEDD4LNCI_NATURE;

reacts with

 NKX2-5NCI_NATURE;

reacts with

 RBBP4NCI_NATURE;

reacts with

 RBBP7NCI_NATURE;

reacts with

 SAP18NCI_NATURE;

reacts with

 SAP30NCI_NATURE;

reacts with

 SIN3ANCI_NATURE;

reacts with

 SIN3BNCI_NATURE;

reacts with

 SKILNCI_NATURE;

reacts with

 SMAD2CELL_MAP;

reacts with

 SMAD2NCI_NATURE;

reacts with

 SMAD4CELL_MAP;

reacts with

 SMAD4NCI_NATURE;

reacts with

 SMURF2NCI_NATURE;

reacts with

 TGFBR1NCI_NATURE;

reacts with

 TGFBR2NCI_NATURE;

reacts with

 TGFBRAP1NCI_NATURE;

reacts with

 ZFYVE16NCI_NATURE;

state change

 CALM1NCI_NATURE;

state change

 Camk2aCELL_MAP;

state change

 CAMK2ANCI_NATURE;

state change

 Camk2bCELL_MAP;

state change

 Camk2dCELL_MAP;

state change

 CITED1NCI_NATURE;

state change

 CTBP1NCI_NATURE;

state change

 EP300NCI_NATURE;

state change

 GPC1NCI_NATURE;

state change

 HDAC1NCI_NATURE;

state change

 HDAC2NCI_NATURE;

state change

 HSPA8NCI_NATURE;

state change

 KAT2BNCI_NATURE;

state change

 KPNA2NCI_NATURE;

state change

 MAP3K1NCI_NATURE;

state change

 MAPK1CELL_MAP;

state change

 NCOR1NCI_NATURE;

state change

 NUP153NCI_NATURE;

state change

 NUP214NCI_NATURE;

state change

 PIAS3NCI_NATURE;

state change

 PPM1ANCI_NATURE;

state change

 RBBP4NCI_NATURE;

state change

 RBBP7NCI_NATURE;

state change

 SAP18NCI_NATURE;

state change

 SAP30NCI_NATURE;

state change

 SIN3ANCI_NATURE;

state change

 SIN3BNCI_NATURE;

state change

 SKINCI_NATURE;

state change

 SMAD7NCI_NATURE;

state change

 SNIP1NCI_NATURE;

state change

 STRAPNCI_NATURE;

state change

 TGFBR1NCI_NATURE;

state change

 TGFBR2NCI_NATURE;

state change

 TGIF1NCI_NATURE;

state change

 UBE2D2CELL_MAP;

state change

 UBE2D3CELL_MAP;

state change

 ZFYVE9NCI_NATURE;

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