Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5777

Name

PTPN6

Synonymous

HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1;protein tyrosine phosphatase, non-receptor type 6;PTPN6;protein tyrosine phosphatase, non-receptor type 6

Definition

hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6

Position

12p13

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 CD72NCI_NATURE;

in same component

 GHRREACTOME;

in same component

 IL2RGNCI_NATURE;

in same component

 IL4NCI_NATURE;

in same component

 IL4RNCI_NATURE;

in same component

 JAK1NCI_NATURE;

in same component

 JAK2REACTOME;

in same component

 JAK3NCI_NATURE;

in same component

 KITREACTOME;

in same component

 PECAM1REACTOME;

interacts with

 ABL1BIOGRID;

interacts with

 ACTN1HPRD;

interacts with

 ACTN4HPRD;

interacts with

 BLNKBIOGRID;

interacts with

 BLNKHPRD;

interacts with

 BTLAHPRD;

interacts with

 BTLAMINT;

interacts with

 CAV1BIOGRID;

interacts with

 CAV1HPRD;

interacts with

 CAV1MINT;

interacts with

 CBLBIOGRID;

interacts with

 CBLHPRD;

interacts with

 CD22BIOGRID;

interacts with

 CD247HPRD;

interacts with

 CD300LFHPRD;

interacts with

 CD300LFMINT;

interacts with

 CD33BIOGRID;

interacts with

 CD33HPRD;

interacts with

 CD33MINT;

interacts with

 CD5BIOGRID;

interacts with

 CD5HPRD;

interacts with

 CD72BIOGRID;

interacts with

 CD72HPRD;

interacts with

 CD79AHPRD;

interacts with

 CD79BHPRD;

interacts with

 CEACAM1HPRD;

interacts with

 CLEC4AHPRD;

interacts with

 CSF2RBBIOGRID;

interacts with

 CSF2RBHPRD;

interacts with

 CSF2RBMINT;

interacts with

 CTNNB1HPRD;

interacts with

 CTNND1BIOGRID;

interacts with

 CTNND1CELL_MAP;

interacts with

 CTNND1HPRD;

interacts with

 CUZD1HPRD;

interacts with

 CXCR4BIOGRID;

interacts with

 CXCR4HPRD;

interacts with

 DOK1HPRD;

interacts with

 EGFRBIOGRID;

interacts with

 EGFRCELL_MAP;

interacts with

 EGFRHPRD;

interacts with

 EGFRMINT;

interacts with

 EPORBIOGRID;

interacts with

 EPORHPRD;

interacts with

 EPORMINT;

interacts with

 ESR1HPRD;

interacts with

 ESR1MINT;

interacts with

 FCGR2BHPRD;

interacts with

 FCGR2BMINT;

interacts with

 FCRL3BIOGRID;

interacts with

 FLT3HPRD;

interacts with

 G6BBIOGRID;

interacts with

 G6BMINT;

interacts with

 GAB2BIOGRID;

interacts with

 GAB2HPRD;

interacts with

 GHRHPRD;

interacts with

 HOXA10BIOGRID;

interacts with

 HOXA10HPRD;

interacts with

 IFNAR1HPRD;

interacts with

 IL2RBHPRD;

interacts with

 IL4RBIOGRID;

interacts with

 IL4RHPRD;

interacts with

 IL4RMINT;

interacts with

 IL6STBIOGRID;

interacts with

 IL6STHPRD;

interacts with

 INSRBIOGRID;

interacts with

 INSRHPRD;

interacts with

 IRS2HPRD;

interacts with

 IRS4HPRD;

interacts with

 JAK1BIOGRID;

interacts with

 JAK1HPRD;

interacts with

 JAK2BIOGRID;

interacts with

 JAK2HPRD;

interacts with

 JAK3HPRD;

interacts with

 KDRHPRD;

interacts with

 KHDRBS1HPRD;

interacts with

 KIR2DL1MINT;

interacts with

 KIR2DL3HPRD;

interacts with

 KIR2DL3MINT;

interacts with

 KIR2DL5AHPRD;

interacts with

 KITBIOGRID;

interacts with

 KITHPRD;

interacts with

 KitMINT;

interacts with

 KLRB1HPRD;

interacts with

 KLRC1HPRD;

interacts with

 LAIR1BIOGRID;

interacts with

 LAIR1HPRD;

interacts with

 LAIR1MINT;

interacts with

 LCKBIOGRID;

interacts with

 LCKHPRD;

interacts with

 LCP2BIOGRID;

interacts with

 LCP2HPRD;

interacts with

 LIFRBIOGRID;

interacts with

 LIFRHPRD;

interacts with

 LILRB1BIOGRID;

interacts with

 LILRB2BIOGRID;

interacts with

 LILRB2HPRD;

interacts with

 LILRB4BIOGRID;

interacts with

 LILRB4HPRD;

interacts with

 LYNBIOGRID;

interacts with

 LYNHPRD;

interacts with

 MAP3K4MINT;

interacts with

 MS4A2HPRD;

interacts with

 MYH9HPRD;

interacts with

 NOS1BIOGRID;

interacts with

 NOS1HPRD;

interacts with

 PAG1BIOGRID;

interacts with

 PAG1HPRD;

interacts with

 PDCD1MINT;

interacts with

 PECAM1BIOGRID;

interacts with

 PECAM1HPRD;

interacts with

 PECAM1MINT;

interacts with

 PIK3R1BIOGRID;

interacts with

 PIK3R1HPRD;

interacts with

 PIK3R1MINT;

interacts with

 PILRABIOGRID;

interacts with

 PILRAHPRD;

interacts with

 PILRAMINT;

interacts with

 PILRBHPRD;

interacts with

 PRKCAHPRD;

interacts with

 PRKCDBIOGRID;

interacts with

 PRKCDHPRD;

interacts with

 PTK2BBIOGRID;

interacts with

 PTK2BHPRD;

interacts with

 PTPN11HPRD;

interacts with

 PTPRCHPRD;

interacts with

 ROS1BIOGRID;

interacts with

 ROS1HPRD;

interacts with

 Ros1MINT;

interacts with

 ROS1MINT;

interacts with

 SH3BP2MINT;

interacts with

 SHC1HPRD;

interacts with

 SIGLEC10HPRD;

interacts with

 SIGLEC10MINT;

interacts with

 SIGLEC11BIOGRID;

interacts with

 SIGLEC11HPRD;

interacts with

 SIGLEC12HPRD;

interacts with

 SIRPABIOGRID;

interacts with

 SIRPAHPRD;

interacts with

 SLAMF6BIOGRID;

interacts with

 SOS1BIOGRID;

interacts with

 SOS1HPRD;

interacts with

 SPATA2HPRD;

interacts with

 SRCHPRD;

interacts with

 SSTR2BIOGRID;

interacts with

 SSTR2HPRD;

interacts with

 STAT5BBIOGRID;

interacts with

 STAT5BHPRD;

interacts with

 STAT6HPRD;

interacts with

 SYKBIOGRID;

interacts with

 SYKHPRD;

interacts with

 TFGHPRD;

interacts with

 TFGMINT;

interacts with

 TMEM62HPRD;

interacts with

 TNFRSF1AHPRD;

interacts with

 TNFRSF1AMINT;

interacts with

 TRAF6HPRD;

interacts with

 TREML1BIOGRID;

interacts with

 TREML1HPRD;

interacts with

 TYK2BIOGRID;

interacts with

 TYK2HPRD;

interacts with

 VAV1BIOGRID;

interacts with

 VAV1HPRD;

interacts with

 ZAP70BIOGRID;

interacts with

 ZAP70HPRD;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

sequential catalysis

 PTPN6HUMANCYC;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 BLNKNCI_NATURE;

reacts with

 BTKNCI_NATURE;

reacts with

 CD72NCI_NATURE;

reacts with

 CD79ANCI_NATURE;

reacts with

 CD79BNCI_NATURE;

reacts with

 GHRREACTOME;

reacts with

 IL2RGNCI_NATURE;

reacts with

 IL4NCI_NATURE;

reacts with

 IL4RNCI_NATURE;

reacts with

 JAK1NCI_NATURE;

reacts with

 JAK2REACTOME;

reacts with

 JAK3NCI_NATURE;

reacts with

 KITREACTOME;

reacts with

 LYNNCI_NATURE;

reacts with

 PECAM1REACTOME;

reacts with

 PLCG2NCI_NATURE;

reacts with

 PTPN6NCI_NATURE;

reacts with

 PTPN6REACTOME;

reacts with

 SYKNCI_NATURE;

state change

 B2MNCI_NATURE;

state change

 CD22NCI_NATURE;

state change

 CD247NCI_NATURE;

state change

 CD3DNCI_NATURE;

state change

 CD3ENCI_NATURE;

state change

 CD3GNCI_NATURE;

state change

 CD4NCI_NATURE;

state change

 CD8ANCI_NATURE;

state change

 CD8BNCI_NATURE;

state change

 EGFNCI_NATURE;

state change

 EGFRCELL_MAP;

state change

 EGFRNCI_NATURE;

state change

 EPONCI_NATURE;

state change

 EPORNCI_NATURE;

state change

 GHRREACTOME;

state change

 HLA-ANCI_NATURE;

state change

 HLA-DRANCI_NATURE;

state change

 HLA-DRB1NCI_NATURE;

state change

 JAK2NCI_NATURE;

state change

 JAK2REACTOME;

state change

 LCKNCI_NATURE;

state change

 PTPN6CELL_MAP;

state change

 PTPN6REACTOME;

')