Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

672

Name

BRCA1

Synonymous

BRCAI|BRCC1|BROVCA1|FANCS|IRIS|PNCA4|PPP1R53|PSCP|RNF53;breast cancer 1, early onset;BRCA1;breast cancer 1, early onset

Definition

BRCA1/BRCA2-containing complex, subunit 1|Fanconi anemia, complementation group S|RING finger protein 53|breast and ovarian cancer susceptibility protein 1|breast and ovarian cancer sususceptibility protein 1|breast cancer type 1 susceptibility protein|pr

Position

17q21

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ATF2NCI_NATURE;

in same component

 ATMNCI_NATURE;

in same component

 ATMREACTOME;

in same component

 ATRREACTOME;

in same component

 AURKANCI_NATURE;

in same component

 BARD1NCI_NATURE;

in same component

 BRCA2REACTOME;

in same component

 CDK4REACTOME;

in same component

 CSTF1NCI_NATURE;

in same component

 CTBP1NCI_NATURE;

in same component

 DMC1REACTOME;

in same component

 ESR1NCI_NATURE;

in same component

 FAM175ANCI_NATURE;

in same component

 H2AFXNCI_NATURE;

in same component

 H2AFXREACTOME;

in same component

 HIST3H3REACTOME;

in same component

 MDC1NCI_NATURE;

in same component

 MDC1REACTOME;

in same component

 MRE11ANCI_NATURE;

in same component

 NBNNCI_NATURE;

in same component

 NF1NCI_NATURE;

in same component

 PALB2REACTOME;

in same component

 PCNANCI_NATURE;

in same component

 POU2F1NCI_NATURE;

in same component

 RAD21REACTOME;

in same component

 RAD50NCI_NATURE;

in same component

 RAD51NCI_NATURE;

in same component

 RAD51REACTOME;

in same component

 RBBP8NCI_NATURE;

in same component

 REC8REACTOME;

in same component

 RNF8NCI_NATURE;

in same component

 RPA1REACTOME;

in same component

 RPA2REACTOME;

in same component

 RPA3REACTOME;

in same component

 SMC1AREACTOME;

in same component

 SMC1BREACTOME;

in same component

 SMC3REACTOME;

in same component

 STAG1REACTOME;

in same component

 STAG2REACTOME;

in same component

 STAG3REACTOME;

in same component

 SYCP2REACTOME;

in same component

 SYCP3REACTOME;

in same component

 TOPBP1NCI_NATURE;

in same component

 TP53BP1NCI_NATURE;

in same component

 TP53BP1REACTOME;

in same component

 TP53NCI_NATURE;

in same component

 UBE2D3NCI_NATURE;

in same component

 UBE2L3NCI_NATURE;

in same component

 UIMC1NCI_NATURE;

interacts with

 ABL1BIOGRID;

interacts with

 ABL1MINT;

interacts with

 ACACABIOGRID;

interacts with

 AKT1BIOGRID;

interacts with

 AKT1INTACT;

interacts with

 APLP2BIOGRID;

interacts with

 ARBIOGRID;

interacts with

 ARCELL_MAP;

interacts with

 ARNTBIOGRID;

interacts with

 ATF1BIOGRID;

interacts with

 ATMBIOGRID;

interacts with

 ATRBIOGRID;

interacts with

 AURKABIOGRID;

interacts with

 BACH1BIOGRID;

interacts with

 BARD1BIOGRID;

interacts with

 BARD1MINT;

interacts with

 BARD1NCI_NATURE;

interacts with

 BLMBIOGRID;

interacts with

 BRAPBIOGRID;

interacts with

 BRAPMINT;

interacts with

 BRCA1NCI_NATURE;

interacts with

 BRCA2BIOGRID;

interacts with

 BRCC3BIOGRID;

interacts with

 BRD7BIOGRID;

interacts with

 BREBIOGRID;

interacts with

 BRIP1BIOGRID;

interacts with

 BRIP1MINT;

interacts with

 CCNA1BIOGRID;

interacts with

 CCNA2BIOGRID;

interacts with

 CCNB1BIOGRID;

interacts with

 CCND1BIOGRID;

interacts with

 CCNE1BIOGRID;

interacts with

 CDK16BIOGRID;

interacts with

 CDK1BIOGRID;

interacts with

 CDK2BIOGRID;

interacts with

 CDK4BIOGRID;

interacts with

 CDK5BIOGRID;

interacts with

 CDK8BIOGRID;

interacts with

 CDKN2DBIOGRID;

interacts with

 CDS1BIOGRID;

interacts with

 CHEK2BIOGRID;

interacts with

 CLSPNBIOGRID;

interacts with

 COBRA1BIOGRID;

interacts with

 CREBBPBIOGRID;

interacts with

 CSNK2A1BIOGRID;

interacts with

 CSNK2BBIOGRID;

interacts with

 CSTF1BIOGRID;

interacts with

 CSTF2BIOGRID;

interacts with

 CTBP1BIOGRID;

interacts with

 CTCFLBIOGRID;

interacts with

 DHX9BIOGRID;

interacts with

 DNAJA3BIOGRID;

interacts with

 E2F4BIOGRID;

interacts with

 ELK4BIOGRID;

interacts with

 EP300BIOGRID;

interacts with

 ESR1BIOGRID;

interacts with

 ESR1MINT;

interacts with

 ETS1BIOGRID;

interacts with

 FANCABIOGRID;

interacts with

 FANCAMINT;

interacts with

 FANCD2BIOGRID;

interacts with

 FANCD2MINT;

interacts with

 FHL2BIOGRID;

interacts with

 FLI1BIOGRID;

interacts with

 FOXO3BIOGRID;

interacts with

 GFI1BMINT;

interacts with

 GTF2E1BIOGRID;

interacts with

 GTF2F1BIOGRID;

interacts with

 GTF2H4BIOGRID;

interacts with

 H2AFXBIOGRID;

interacts with

 H2AFYBIOGRID;

interacts with

 HDAC1BIOGRID;

interacts with

 HDAC2BIOGRID;

interacts with

 HIST2H2ACBIOGRID;

interacts with

 HIST2H3ABIOGRID;

interacts with

 HSPA8BIOGRID;

interacts with

 Ifi204BIOGRID;

interacts with

 JAK1BIOGRID;

interacts with

 JAK1MINT;

interacts with

 JAK2BIOGRID;

interacts with

 JAK2MINT;

interacts with

 JUNBBIOGRID;

interacts with

 JUNBIOGRID;

interacts with

 JUNDBIOGRID;

interacts with

 KAT2ABIOGRID;

interacts with

 KIF1BBIOGRID;

interacts with

 KPNA2BIOGRID;

interacts with

 MAP3K3BIOGRID;

interacts with

 MAP4K4BIOGRID;

interacts with

 MDC1BIOGRID;

interacts with

 MED13BIOGRID;

interacts with

 MED17BIOGRID;

interacts with

 MED1BIOGRID;

interacts with

 MED21BIOGRID;

interacts with

 MED23BIOGRID;

interacts with

 MED24BIOGRID;

interacts with

 MLH1BIOGRID;

interacts with

 MLH1MINT;

interacts with

 MORF4L1BIOGRID;

interacts with

 MRE11ABIOGRID;

interacts with

 MRPL36BIOGRID;

interacts with

 MSH2BIOGRID;

interacts with

 MSH3BIOGRID;

interacts with

 MSH6BIOGRID;

interacts with

 MYCBIOGRID;

interacts with

 NBNBIOGRID;

interacts with

 NCK1MINT;

interacts with

 NCOA2BIOGRID;

interacts with

 NCOA3BIOGRID;

interacts with

 NFYABIOGRID;

interacts with

 NMIBIOGRID;

interacts with

 NUFIP1BIOGRID;

interacts with

 NUP153BIOGRID;

interacts with

 ORC2BIOGRID;

interacts with

 ORC3BIOGRID;

interacts with

 PALB2BIOGRID;

interacts with

 PEG3BIOGRID;

interacts with

 PIAS1BIOGRID;

interacts with

 PIAS4BIOGRID;

interacts with

 PIK3R1MINT;

interacts with

 PMS2MINT;

interacts with

 POLR2ABIOGRID;

interacts with

 POU2F1BIOGRID;

interacts with

 PPP1CABIOGRID;

interacts with

 PPP1CBBIOGRID;

interacts with

 PPP1R3ABIOGRID;

interacts with

 PRKDCBIOGRID;

interacts with

 PRMT1BIOGRID;

interacts with

 RAD23BMINT;

interacts with

 RAD50BIOGRID;

interacts with

 RAD51BIOGRID;

interacts with

 RB1BIOGRID;

interacts with

 RBBP4BIOGRID;

interacts with

 RBBP7BIOGRID;

interacts with

 RBBP8BIOGRID;

interacts with

 RBL1BIOGRID;

interacts with

 RBL2BIOGRID;

interacts with

 RELABIOGRID;

interacts with

 RFC1BIOGRID;

interacts with

 RPA1BIOGRID;

interacts with

 SMARCA2BIOGRID;

interacts with

 SMARCA4BIOGRID;

interacts with

 SMARCB1BIOGRID;

interacts with

 SMARCC1BIOGRID;

interacts with

 SMARCD2BIOGRID;

interacts with

 SP1BIOGRID;

interacts with

 SRCBIOGRID;

interacts with

 STAT1BIOGRID;

interacts with

 STAT5ABIOGRID;

interacts with

 TERF1BIOGRID;

interacts with

 TERF2BIOGRID;

interacts with

 TOP2ABIOGRID;

interacts with

 TP53BP1BIOGRID;

interacts with

 TP53BIOGRID;

interacts with

 TRRAPBIOGRID;

interacts with

 TUBG1BIOGRID;

interacts with

 UBA1BIOGRID;

interacts with

 UBE2D1BIOGRID;

interacts with

 UBE2IBIOGRID;

interacts with

 UBE2J1BIOGRID;

interacts with

 UBE2L3BIOGRID;

interacts with

 UBE3ABIOGRID;

interacts with

 UIMC1BIOGRID;

interacts with

 USF2BIOGRID;

interacts with

 VCPBIOGRID;

interacts with

 WDR48BIOGRID;

interacts with

 WNT2BBIOGRID;

interacts with

 XRCC5BIOGRID;

interacts with

 ZCCHC8BIOGRID;

interacts with

 ZNF350BIOGRID;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 E2F4NCI_NATURE;

metabolic catalysis

 E2F6NCI_NATURE;

metabolic catalysis

 TFDP2NCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 ATF2NCI_NATURE;

reacts with

 ATMNCI_NATURE;

reacts with

 ATMREACTOME;

reacts with

 ATRREACTOME;

reacts with

 AURKANCI_NATURE;

reacts with

 BARD1NCI_NATURE;

reacts with

 BRCA1NCI_NATURE;

reacts with

 BRCA1REACTOME;

reacts with

 BRCA2REACTOME;

reacts with

 CDK4REACTOME;

reacts with

 CSTF1NCI_NATURE;

reacts with

 CTBP1NCI_NATURE;

reacts with

 DMC1REACTOME;

reacts with

 ESR1NCI_NATURE;

reacts with

 FAM175ANCI_NATURE;

reacts with

 H2AFXNCI_NATURE;

reacts with

 H2AFXREACTOME;

reacts with

 HIST3H3REACTOME;

reacts with

 MDC1NCI_NATURE;

reacts with

 MDC1REACTOME;

reacts with

 MRE11ANCI_NATURE;

reacts with

 NBNNCI_NATURE;

reacts with

 NF1NCI_NATURE;

reacts with

 PALB2REACTOME;

reacts with

 PCNANCI_NATURE;

reacts with

 POU2F1NCI_NATURE;

reacts with

 RAD21REACTOME;

reacts with

 RAD50NCI_NATURE;

reacts with

 RAD51NCI_NATURE;

reacts with

 RAD51REACTOME;

reacts with

 RBBP8NCI_NATURE;

reacts with

 REC8REACTOME;

reacts with

 RNF8NCI_NATURE;

reacts with

 RPA1REACTOME;

reacts with

 RPA2REACTOME;

reacts with

 RPA3REACTOME;

reacts with

 SMC1AREACTOME;

reacts with

 SMC1BREACTOME;

reacts with

 SMC3REACTOME;

reacts with

 STAG1REACTOME;

reacts with

 STAG2REACTOME;

reacts with

 STAG3REACTOME;

reacts with

 SYCP2REACTOME;

reacts with

 SYCP3REACTOME;

reacts with

 TOPBP1NCI_NATURE;

reacts with

 TP53BP1NCI_NATURE;

reacts with

 TP53BP1REACTOME;

reacts with

 TP53NCI_NATURE;

reacts with

 UBE2D3NCI_NATURE;

reacts with

 UBE2L3NCI_NATURE;

reacts with

 UIMC1NCI_NATURE;

state change

 ATMNCI_NATURE;

state change

 ATMREACTOME;

state change

 ATRNCI_NATURE;

state change

 BRCA1REACTOME;

state change

 BRCA2REACTOME;

state change

 CCNE1NCI_NATURE;

state change

 CDK2NCI_NATURE;

state change

 CDK4REACTOME;

state change

 DMC1REACTOME;

state change

 H2AFXREACTOME;

state change

 HIST3H3REACTOME;

state change

 MDC1REACTOME;

state change

 MND1REACTOME;

state change

 PSMC3IPREACTOME;

state change

 RAD51REACTOME;

state change

 RAD51CREACTOME;

state change

 RPA1REACTOME;

state change

 RPA2REACTOME;

state change

 RPA3REACTOME;

state change

 TEX15REACTOME;

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