Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

841

Name

CASP8

Synonymous

ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5;caspase 8, apoptosis-related cysteine peptidase;CASP8;caspase 8, apoptosis-related cysteine peptidase

Definition

FADD-homologous ICE/CED-3-like protease|FADD-like ICE|ICE-like apoptotic protease 5|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|MORT1-associated ced-3 homolog|apoptotic cysteine protease|apoptotic protease Mch-5|caspase 8, apoptosis-related cystein

Position

2q33-q34

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ARNCI_NATURE;

in same component

 BCAP31IMID;

in same component

 CFLARIMID;

in same component

 CFLARNCI_NATURE;

in same component

 DAXXNCI_NATURE;

in same component

 FADDIMID;

in same component

 FADDNCI_NATURE;

in same component

 FADDREACTOME;

in same component

 FASNCI_NATURE;

in same component

 FASREACTOME;

in same component

 FASLGNCI_NATURE;

in same component

 FASLGREACTOME;

in same component

 MAP3K5NCI_NATURE;

in same component

 RIPK1REACTOME;

in same component

 TNFRSF10BREACTOME;

in same component

 TNFSF10REACTOME;

in same component

 TRADDREACTOME;

in same component

 TRAF2REACTOME;

interacts with

 APAF1BIOGRID;

interacts with

 APAF1HPRD;

interacts with

 ARHPRD;

interacts with

 ARMINT;

interacts with

 ARHGDIABIOGRID;

interacts with

 BCAP31BIOGRID;

interacts with

 BCAP31HPRD;

interacts with

 BCAP31INTACT;

interacts with

 BCL2BIOGRID;

interacts with

 BCL2HPRD;

interacts with

 BCL2L1HPRD;

interacts with

 BFARHPRD;

interacts with

 BIDBIOGRID;

interacts with

 BIRC2BIOGRID;

interacts with

 BIRC2HPRD;

interacts with

 CASP10BIOGRID;

interacts with

 CASP10CELL_MAP;

interacts with

 CASP10HPRD;

interacts with

 CASP10MINT;

interacts with

 CASP14BIOGRID;

interacts with

 CASP14HPRD;

interacts with

 CASP1BIOGRID;

interacts with

 CASP2BIOGRID;

interacts with

 CASP3BIOGRID;

interacts with

 CASP3HPRD;

interacts with

 CASP4BIOGRID;

interacts with

 CASP6BIOGRID;

interacts with

 CASP6HPRD;

interacts with

 CASP7BIOGRID;

interacts with

 CASP8AP2BIOGRID;

interacts with

 CASP8AP2HPRD;

interacts with

 CASP8AP2MINT;

interacts with

 Casp8MINT;

interacts with

 CASP9BIOGRID;

interacts with

 CDH1HPRD;

interacts with

 CDK11AHPRD;

interacts with

 CDK11BHPRD;

interacts with

 CDKN1BHPRD;

interacts with

 CFLARBIOGRID;

interacts with

 CFLARHPRD;

interacts with

 CHD3BIOGRID;

interacts with

 CHD3MINT;

interacts with

 CHUKBIOGRID;

interacts with

 CHUKHPRD;

interacts with

 CRADDHPRD;

interacts with

 CTNNB1HPRD;

interacts with

 DEDD2BIOGRID;

interacts with

 DEDD2HPRD;

interacts with

 DEDDBIOGRID;

interacts with

 DEDDHPRD;

interacts with

 EDA2RHPRD;

interacts with

 EIF2AK2HPRD;

interacts with

 EZRBIOGRID;

interacts with

 FADDBIOGRID;

interacts with

 FADDCELL_MAP;

interacts with

 FADDHPRD;

interacts with

 FADDINTACT;

interacts with

 FADDMINT;

interacts with

 FAF1BIOGRID;

interacts with

 FAF1HPRD;

interacts with

 FASBIOGRID;

interacts with

 FASMINT;

interacts with

 FASLGBIOGRID;

interacts with

 FASLGMINT;

interacts with

 FIS1INTACT;

interacts with

 FYNHPRD;

interacts with

 GMEB1HPRD;

interacts with

 HDAC7BIOGRID;

interacts with

 HIP1BIOGRID;

interacts with

 HIP1HPRD;

interacts with

 IFT57BIOGRID;

interacts with

 IFT57HPRD;

interacts with

 IKBKBBIOGRID;

interacts with

 IKBKBHPRD;

interacts with

 ILKHPRD;

interacts with

 KRR1HPRD;

interacts with

 KRT18HPRD;

interacts with

 MAP3K14BIOGRID;

interacts with

 MAP3K14HPRD;

interacts with

 MAP4K4HPRD;

interacts with

 MAPK1HPRD;

interacts with

 MAPK1MINT;

interacts with

 MAPK3HPRD;

interacts with

 MAPK3MINT;

interacts with

 MAPK8BIOGRID;

interacts with

 MAPTHPRD;

interacts with

 MSNBIOGRID;

interacts with

 NCLMINT;

interacts with

 NLRC4BIOGRID;

interacts with

 NLRC4HPRD;

interacts with

 NOD1BIOGRID;

interacts with

 NOD1HPRD;

interacts with

 NOL3BIOGRID;

interacts with

 NOL3HPRD;

interacts with

 NR1H4BIOGRID;

interacts with

 NR1H4HPRD;

interacts with

 NUCB1MINT;

interacts with

 NUCB2MINT;

interacts with

 PARK2HPRD;

interacts with

 PARP2HPRD;

interacts with

 PCYT1AHPRD;

interacts with

 PEA15BIOGRID;

interacts with

 PEA15HPRD;

interacts with

 PIAS1HPRD;

interacts with

 PICALMHPRD;

interacts with

 PLECHPRD;

interacts with

 PRKCZHPRD;

interacts with

 PSEN1HPRD;

interacts with

 PSEN2HPRD;

interacts with

 PYCARDHPRD;

interacts with

 RALBP1BIOGRID;

interacts with

 RALBP1HPRD;

interacts with

 RALGDSBIOGRID;

interacts with

 RB1HPRD;

interacts with

 RHOABIOGRID;

interacts with

 RIPK1BIOGRID;

interacts with

 RIPK1CELL_MAP;

interacts with

 RIPK1HPRD;

interacts with

 RIPK1INTACT;

interacts with

 RIPK2HPRD;

interacts with

 RYBPHPRD;

interacts with

 SRFHPRD;

interacts with

 STK24HPRD;

interacts with

 TFCP2BIOGRID;

interacts with

 TFCP2HPRD;

interacts with

 TFCP2MINT;

interacts with

 TNFAIP3BIOGRID;

interacts with

 TNFRSF10ABIOGRID;

interacts with

 TNFRSF10AHPRD;

interacts with

 TNFRSF10BBIOGRID;

interacts with

 TNFRSF10BHPRD;

interacts with

 TNFRSF1ABIOGRID;

interacts with

 TNFRSF1AHPRD;

interacts with

 TOPORSHPRD;

interacts with

 TOPORSMINT;

interacts with

 TRADDBIOGRID;

interacts with

 TRADDCELL_MAP;

interacts with

 TRADDHPRD;

interacts with

 TRAF1BIOGRID;

interacts with

 TRAF1HPRD;

interacts with

 TRAF2BIOGRID;

interacts with

 TRAF2CELL_MAP;

interacts with

 TRAF2HPRD;

interacts with

 USO1HPRD;

interacts with

 VIMBIOGRID;

interacts with

 VIMHPRD;

interacts with

 VIMMINT;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 FADDREACTOME;

metabolic catalysis

 MAVSREACTOME;

metabolic catalysis

 RIPK1REACTOME;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 BCAP31IMID;

reacts with

 CASP10REACTOME;

reacts with

 CASP8IMID;

reacts with

 CASP8NCI_NATURE;

reacts with

 CASP8REACTOME;

reacts with

 CFLARIMID;

reacts with

 CFLARNCI_NATURE;

reacts with

 DAXXNCI_NATURE;

reacts with

 FADDIMID;

reacts with

 FADDNCI_NATURE;

reacts with

 FADDREACTOME;

reacts with

 FASNCI_NATURE;

reacts with

 FASREACTOME;

reacts with

 FASLGNCI_NATURE;

reacts with

 FASLGREACTOME;

reacts with

 ITGAVNCI_NATURE;

reacts with

 ITGB3NCI_NATURE;

reacts with

 MAP3K5NCI_NATURE;

reacts with

 MAVSREACTOME;

reacts with

 RIPK1REACTOME;

reacts with

 TNFRSF10BREACTOME;

reacts with

 TNFSF10REACTOME;

reacts with

 TRADDREACTOME;

reacts with

 TRAF2REACTOME;

state change

 BIRC2NCI_NATURE;

state change

 BIRC3NCI_NATURE;

state change

 CASP8NCI_NATURE;

state change

 CFLARNCI_NATURE;

state change

 CLTCNCI_NATURE;

state change

 CRADDNCI_NATURE;

state change

 DAP3NCI_NATURE;

state change

 EZRNCI_NATURE;

state change

 FADDNCI_NATURE;

state change

 FASNCI_NATURE;

state change

 FASLGNCI_NATURE;

state change

 MADDNCI_NATURE;

state change

 NFKB1NCI_NATURE;

state change

 RELANCI_NATURE;

state change

 RIPK1NCI_NATURE;

state change

 TNFNCI_NATURE;

state change

 TNFRSF10ANCI_NATURE;

state change

 TNFRSF10BNCI_NATURE;

state change

 TNFRSF1ANCI_NATURE;

state change

 TNFSF10NCI_NATURE;

state change

 TRADDNCI_NATURE;

state change

 TRAF2NCI_NATURE;

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