Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10077

Name

TSPAN32

Synonymous

tetraspanin 32;TSPAN32;tetraspanin 32

Definition

pan-hematopoietic expression protein|protein Phemx|tetraspanin-32|tspan-32|tumor-suppressing STF cDNA 6|tumor-suppressing subchromosomal transferable fragment cDNA 6|tumor-suppressing subtransferable candidate 6

Position

11p15.5

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.21.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.456+6C>T; p.?; 11:2313761-2313761

 pancreascarcinomaUnknown

c.144_145CC>TT; p.(=); 11:2302921-2302922

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.732C>T; p.R244R; 11:2317356-2317356

 pancreascarcinomaSubstitution - coding silent

c.696G>A; p.K232K; 11:2316644-2316644

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.226G>C; p.A76P; 11:2304151-2304151

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.946C>T; p.R316W; 11:2317907-2317907

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.856G>T; p.D286Y; 11:2317480-2317480

 skinmalignant_melanomaSubstitution - Missense

c.9T>A; p.P3P; 11:2302158-2302158

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - coding silent

c.718C>A; p.R240R; 11:2316666-2316666

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.281G>A; p.G94D; 11:2308737-2308737

 skinmalignant_melanomaSubstitution - Missense

c.299T>A; p.L100Q; 11:2308755-2308755

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.454G>A; p.V152M; 11:2313753-2313753

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.911_912GC>TG; p.G304V; 11:2317872-2317873

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.939C>T; p.C313C; 11:2317900-2317900

 pancreascarcinomaSubstitution - coding silent

c.523G>A; p.G175R; 11:2314551-2314551

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.475_476delAA; p.K159fs*12; 11:2314503-2314504

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.739C>A; p.Q247K; 11:2317363-2317363

 skinmalignant_melanomaSubstitution - Missense

c.755T>C; p.L252S; 11:2317379-2317379

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.382G>A; p.D128N; 11:2313681-2313681

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.829G>A; p.G277S; 11:2317453-2317453

 skinmalignant_melanomaSubstitution - Missense

c.382G>A; p.D128N; 11:2313681-2313681

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.147G>A; p.L49L; 11:2302924-2302924

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.381C>T; p.Y127Y; 11:2313680-2313680

 thyroidcarcinomaSubstitution - coding silent

c.440C>T; p.A147V; 11:2313739-2313739

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.718C>T; p.R240*; 11:2316666-2316666

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.814C>A; p.P272T; 11:2317438-2317438

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.642C>G; p.L214L; 11:2316590-2316590

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.453C>T; p.D151D; 11:2313752-2313752

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.498G>A; p.G166G; 11:2314526-2314526

 skinmalignant_melanomaSubstitution - coding silent

c.394G>A; p.E132K; 11:2313693-2313693

 skinmalignant_melanomaSubstitution - Missense

c.921C>T; p.R307R; 11:2317882-2317882

 livercarcinomaSubstitution - coding silent

c.821G>A; p.G274E; 11:2317445-2317445

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.168T>C; p.A56A; 11:2302945-2302945

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.29C>T; p.A10V; 11:2302178-2302178

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.309C>T; p.C103C; 11:2308765-2308765

 thyroidother; neoplasmSubstitution - coding silent

c.309C>T; p.C103C; 11:2308765-2308765

 thyroidother; neoplasmSubstitution - coding silent

c.689A>G; p.D230G; 11:2316637-2316637

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.402G>A; p.A134A; 11:2313701-2313701

 skinmalignant_melanomaSubstitution - coding silent

c.524G>A; p.G175E; 11:2314552-2314552

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.424C>T; p.R142W; 11:2313723-2313723

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.140C>T; p.A47V; 11:2302917-2302917

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.585G>A; p.Q195Q; 11:2316270-2316270

 breastcarcinomaSubstitution - coding silent

c.948G>A; p.R316R; 11:2317909-2317909

 skinmalignant_melanomaSubstitution - coding silent

c.612C>T; p.I204I; 11:2316297-2316297

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.655_671del17; p.F221fs*52; 11:2316603-2316619

 breastcarcinomaDeletion - Frameshift

c.677G>C; p.G226A; 11:2316625-2316625

 breastcarcinomaSubstitution - Missense

c.919C>T; p.R307C; 11:2317880-2317880

 skinmalignant_melanomaSubstitution - Missense

c.255G>A; p.R85R; 11:2304180-2304180

 breastcarcinomaSubstitution - coding silent

c.279+2T>G; p.?; 11:2304206-2304206

 skin; extremitymalignant_melanomaUnknown

c.628G>A; p.V210M; 11:2316576-2316576

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.636C>T; p.A212A; 11:2316584-2316584

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.636C>T; p.A212A; 11:2316584-2316584

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

')