Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10078

Name

TSSC4

Synonymous

tumor suppressing subtransferable candidate 4;TSSC4;tumor suppressing subtransferable candidate 4

Definition

protein TSSC4|tumor-suppressing STF cDNA 4 protein|tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein

Position

11p15.5

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.609G>A; p.Q203Q; 11:2403242-2403242

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.621C>G; p.S207R; 11:2403254-2403254

 central_nervous_system; braingliomaSubstitution - Missense

c.889C>T; p.P297S; 11:2403522-2403522

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.349A>C; p.S117R; 11:2402982-2402982

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.658C>T; p.R220*; 11:2403291-2403291

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Nonsense

c.623G>A; p.C208Y; 11:2403256-2403256

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.228G>A; p.T76T; 11:2402861-2402861

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.864C>T; p.V288V; 11:2403497-2403497

 breastcarcinomaSubstitution - coding silent

c.970G>A; p.D324N; 11:2403603-2403603

 pancreascarcinomaSubstitution - Missense

c.666C>T; p.V222V; 11:2403299-2403299

 skinmalignant_melanomaSubstitution - coding silent

c.898G>T; p.E300*; 11:2403531-2403531

 skinmalignant_melanomaSubstitution - Nonsense

c.274C>T; p.R92C; 11:2402907-2402907

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.274C>T; p.R92C; 11:2402907-2402907

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.924G>C; p.R308S; 11:2403557-2403557

 breastcarcinomaSubstitution - Missense

c.481C>T; p.R161C; 11:2403114-2403114

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.478G>A; p.E160K; 11:2403111-2403111

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.357C>T; p.N119N; 11:2402990-2402990

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.322C>T; p.P108S; 11:2402955-2402955

 skinmalignant_melanomaSubstitution - Missense

c.269C>T; p.S90F; 11:2402902-2402902

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.549G>T; p.L183L; 11:2403182-2403182

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.617C>G; p.S206C; 11:2403250-2403250

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.820C>T; p.H274Y; 11:2403453-2403453

 skinmalignant_melanomaSubstitution - Missense

c.597C>T; p.S199S; 11:2403230-2403230

 skinmalignant_melanomaSubstitution - coding silent

c.168G>T; p.G56G; 11:2402801-2402801

 pancreascarcinomaSubstitution - coding silent

c.904G>A; p.V302I; 11:2403537-2403537

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.46G>A; p.E16K; 11:2402679-2402679

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.784G>A; p.G262R; 11:2403417-2403417

 thyroidother; neoplasmSubstitution - Missense

c.946C>G; p.R316G; 11:2403579-2403579

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.423T>A; p.H141Q; 11:2403056-2403056

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.630G>A; p.E210E; 11:2403263-2403263

 skinmalignant_melanomaSubstitution - coding silent

c.356A>G; p.N119S; 11:2402989-2402989

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.45C>T; p.G15G; 11:2402678-2402678

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.751G>T; p.G251C; 11:2403384-2403384

 livercarcinomaSubstitution - Missense

c.751G>T; p.G251C; 11:2403384-2403384

 livercarcinomaSubstitution - Missense

c.730G>T; p.G244W; 11:2403363-2403363

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.543C>T; p.T181T; 11:2403176-2403176

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.543C>T; p.T181T; 11:2403176-2403176

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.497G>T; p.S166I; 11:2403130-2403130

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.482G>A; p.R161H; 11:2403115-2403115

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.477C>T; p.P159P; 11:2403110-2403110

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.514G>A; p.E172K; 11:2403147-2403147

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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