Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1036

Name

CDO1

Synonymous

cysteine dioxygenase type 1;CDO1;cysteine dioxygenase type 1

Definition

CDO|CDO-I|cysteine dioxygenase, type I

Position

5q23.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.75C>T; p.G25G; 5:115816323-115816323

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.342C>T; p.S114S; 5:115811222-115811222

 skinmalignant_melanomaSubstitution - coding silent

c.569C>T; p.P190L; 5:115806353-115806353

 skinmalignant_melanomaSubstitution - Missense

c.315A>G; p.T105T; 5:115811249-115811249

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.112G>A; p.E38K; 5:115816286-115816286

 skinmalignant_melanomaSubstitution - Missense

c.69T>G; p.F23L; 5:115816329-115816329

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.486T>C; p.D162D; 5:115806436-115806436

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.76G>A; p.D26N; 5:115816322-115816322

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.76G>A; p.D26N; 5:115816322-115816322

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.76G>A; p.D26N; 5:115816322-115816322

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.329C>G; p.P110R; 5:115811235-115811235

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.427G>C; p.E143Q; 5:115806495-115806495

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.373T>C; p.L125L; 5:115811191-115811191

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.291G>T; p.M97I; 5:115811273-115811273

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.587C>T; p.S196L; 5:115805449-115805449

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.344A>G; p.N115S; 5:115811220-115811220

 skinmalignant_melanomaSubstitution - Missense

c.283C>A; p.L95M; 5:115811281-115811281

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.346G>C; p.E116Q; 5:115811218-115811218

 breastcarcinomaSubstitution - Missense

c.262C>T; p.H88Y; 5:115811302-115811302

 skinmalignant_melanomaSubstitution - Missense

c.115G>T; p.A39S; 5:115816283-115816283

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.561C>G; p.I187M; 5:115806361-115806361

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.285G>C; p.L95L; 5:115811279-115811279

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.64C>T; p.L22F; 5:115816334-115816334

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.80A>C; p.E27A; 5:115816318-115816318

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.443C>T; p.T148M; 5:115806479-115806479

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.443C>T; p.T148M; 5:115806479-115806479

 skin; trunkmalignant_melanoma; nodularSubstitution - Missense

c.443C>T; p.T148M; 5:115806479-115806479

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.443C>T; p.T148M; 5:115806479-115806479

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.484G>C; p.D162H; 5:115806438-115806438

 ovaryother; neoplasmSubstitution - Missense

c.484G>C; p.D162H; 5:115806438-115806438

 ovaryother; neoplasmSubstitution - Missense

c.171-2A>T; p.?; 5:115813260-115813260

 oesophaguscarcinoma; adenocarcinomaUnknown

c.171-2A>T; p.?; 5:115813260-115813260

 skin; trunkmalignant_melanomaUnknown

c.171-2A>T; p.?; 5:115813260-115813260

 large_intestine; rectumcarcinoma; adenocarcinomaUnknown

c.81G>T; p.E27D; 5:115816317-115816317

 skinmalignant_melanomaSubstitution - Missense

c.91G>C; p.E31Q; 5:115816307-115816307

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.65T>C; p.L22P; 5:115816333-115816333

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.372C>A; p.V124V; 5:115811192-115811192

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.159C>T; p.F53F; 5:115816239-115816239

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.288G>C; p.K96N; 5:115811276-115811276

 breastcarcinomaSubstitution - Missense

c.428A>G; p.E143G; 5:115806494-115806494

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.66C>T; p.L22L; 5:115816332-115816332

 skinmalignant_melanomaSubstitution - coding silent

c.123G>C; p.E41D; 5:115816275-115816275

 breastcarcinomaSubstitution - Missense

c.191A>G; p.D64G; 5:115813238-115813238

 livercarcinomaSubstitution - Missense

c.191A>G; p.D64G; 5:115813238-115813238

 livercarcinomaSubstitution - Missense

c.445G>A; p.E149K; 5:115806477-115806477

 skinmalignant_melanomaSubstitution - Missense

c.581C>T; p.S194L; 5:115805455-115805455

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.581C>T; p.S194L; 5:115805455-115805455

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.590T>C; p.L197P; 5:115805446-115805446

 skin; earcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.197G>A; p.G66E; 5:115813232-115813232

 skinmalignant_melanomaSubstitution - Missense

c.197G>A; p.G66E; 5:115813232-115813232

 skin; upper_armmalignant_melanomaSubstitution - Missense

c.299G>A; p.G100E; 5:115811265-115811265

 skinmalignant_melanomaSubstitution - Missense

c.586T>G; p.S196A; 5:115805450-115805450

 breastcarcinoma; HER-positive_carcinomaSubstitution - Missense

c.298G>A; p.G100R; 5:115811266-115811266

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.35T>C; p.L12P; 5:115816363-115816363

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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