Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10562

Name

OLFM4

Synonymous

olfactomedin 4;OLFM4;olfactomedin 4

Definition

G-CSF-stimulated clone 1 protein|antiapoptotic protein GW112|olfactomedin-4

Position

13q14.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1483G>A; p.D495N; 13:53050721-53050721

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1483G>A; p.D495N; 13:53050721-53050721

 skinmalignant_melanomaSubstitution - Missense

c.1326C>T; p.A442A; 13:53050564-53050564

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1145A>G; p.D382G; 13:53050383-53050383

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.205-4G>A; p.?; 13:53034344-53034344

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.643G>T; p.E215*; 13:53043177-53043177

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.374_377delAATT; p.I127fs*8; 13:53041926-53041929

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1298C>T; p.A433V; 13:53050536-53050536

 skinmalignant_melanomaSubstitution - Missense

c.67G>A; p.G23R; 13:53028903-53028903

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.718C>T; p.P240S; 13:53043252-53043252

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.725C>T; p.T242I; 13:53043259-53043259

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.533G>T; p.G178V; 13:53042085-53042085

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.202C>A; p.Q68K; 13:53029038-53029038

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.533G>T; p.G178V; 13:53042085-53042085

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.777G>T; p.V259V; 13:53050015-53050015

 breastcarcinomaSubstitution - coding silent

c.1005C>A; p.N335K; 13:53050243-53050243

 breastcarcinomaSubstitution - Missense

c.1296C>T; p.N432N; 13:53050534-53050534

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.12C>T; p.G4G; 13:53028848-53028848

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1141C>G; p.Q381E; 13:53050379-53050379

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.462G>A; p.L154L; 13:53042014-53042014

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - coding silent

c.22C>A; p.L8I; 13:53028858-53028858

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.631G>T; p.A211S; 13:53043165-53043165

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1035C>T; p.T345T; 13:53050273-53050273

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.11G>A; p.G4D; 13:53028847-53028847

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1286C>A; p.S429Y; 13:53050524-53050524

 breastcarcinomaSubstitution - Missense

c.358-1G>T; p.?; 13:53041909-53041909

 lungcarcinoma; adenocarcinomaUnknown

c.1450A>C; p.N484H; 13:53050688-53050688

 pancreascarcinomaSubstitution - Missense

c.744T>C; p.H248H; 13:53049982-53049982

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.46G>T; p.G16C; 13:53028882-53028882

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1321T>C; p.Y441H; 13:53050559-53050559

 stomachadenocarcinomaSubstitution - Missense

c.505C>T; p.L169L; 13:53042057-53042057

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.946A>T; p.I316L; 13:53050184-53050184

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1038G>A; p.G346G; 13:53050276-53050276

 skin; legmalignant_melanomaSubstitution - coding silent

c.1038G>A; p.G346G; 13:53050276-53050276

 skin; legmalignant_melanomaSubstitution - coding silent

c.993A>C; p.T331T; 13:53050231-53050231

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1512T>A; p.S504S; 13:53050750-53050750

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.346G>T; p.E116*; 13:53034489-53034489

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.229G>T; p.V77L; 13:53034372-53034372

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.229G>T; p.V77L; 13:53034372-53034372

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.656T>C; p.L219P; 13:53043190-53043190

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.570G>T; p.E190D; 13:53042122-53042122

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.325C>A; p.L109I; 13:53034468-53034468

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1432G>C; p.V478L; 13:53050670-53050670

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.204G>T; p.Q68H; 13:53029040-53029040

 ovarycarcinomaSubstitution - Missense

c.989G>A; p.G330D; 13:53050227-53050227

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1404_1405insATTGTA; p.V470_M471insIV; 13:53050642-53050643

 oesophaguscarcinoma; adenocarcinomaInsertion - In frame

c.1469T>G; p.L490R; 13:53050707-53050707

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.699C>T; p.N233N; 13:53043233-53043233

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1244T>G; p.L415R; 13:53050482-53050482

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1281A>G; p.K427K; 13:53050519-53050519

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1349C>A; p.T450K; 13:53050587-53050587

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1037G>A; p.G346E; 13:53050275-53050275

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.925C>A; p.L309M; 13:53050163-53050163

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.284C>A; p.P95H; 13:53034427-53034427

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.586C>T; p.L196F; 13:53043120-53043120

 skinmalignant_melanomaSubstitution - Missense

c.778G>C; p.V260L; 13:53050016-53050016

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1401A>G; p.L467L; 13:53050639-53050639

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.232G>A; p.D78N; 13:53034375-53034375

 breastcarcinomaSubstitution - Missense

c.1344C>A; p.T448T; 13:53050582-53050582

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.39C>T; p.F13F; 13:53028875-53028875

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.642A>T; p.R214R; 13:53043176-53043176

 kidneyother; neoplasmSubstitution - coding silent

c.396G>T; p.K132N; 13:53041948-53041948

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.396G>T; p.K132N; 13:53041948-53041948

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.254G>A; p.C85Y; 13:53034397-53034397

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1511C>T; p.S504F; 13:53050749-53050749

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1263G>A; p.W421*; 13:53050501-53050501

 skinmalignant_melanomaSubstitution - Nonsense

c.173G>A; p.R58H; 13:53029009-53029009

 central_nervous_system; braingliomaSubstitution - Missense

c.974A>T; p.Y325F; 13:53050212-53050212

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1156G>T; p.A386S; 13:53050394-53050394

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1356G>T; p.E452D; 13:53050594-53050594

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1356G>T; p.E452D; 13:53050594-53050594

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.381T>C; p.I127I; 13:53041933-53041933

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.873G>A; p.A291A; 13:53050111-53050111

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1319T>C; p.L440P; 13:53050557-53050557

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1386G>A; p.G462G; 13:53050624-53050624

 skinmalignant_melanomaSubstitution - coding silent

c.861G>T; p.L287L; 13:53050099-53050099

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.893G>A; p.R298K; 13:53050131-53050131

 breastcarcinomaSubstitution - Missense

c.1385G>T; p.G462V; 13:53050623-53050623

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1202G>A; p.S401N; 13:53050440-53050440

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1150G>T; p.D384Y; 13:53050388-53050388

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.964C>T; p.R322W; 13:53050202-53050202

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.224G>T; p.G75V; 13:53034367-53034367

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.153G>A; p.R51R; 13:53028989-53028989

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.409C>G; p.L137V; 13:53041961-53041961

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.285C>A; p.P95P; 13:53034428-53034428

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.868G>T; p.V290L; 13:53050106-53050106

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.704C>T; p.P235L; 13:53043238-53043238

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.59G>T; p.G20V; 13:53028895-53028895

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1121C>T; p.S374L; 13:53050359-53050359

 skinmalignant_melanomaSubstitution - Missense

c.469G>A; p.E157K; 13:53042021-53042021

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1121C>T; p.S374L; 13:53050359-53050359

 skin; abdomenmalignant_melanomaSubstitution - Missense

c.178T>C; p.L60L; 13:53029014-53029014

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.263C>T; p.S88F; 13:53034406-53034406

 skinmalignant_melanomaSubstitution - Missense

c.22C>T; p.L8F; 13:53028858-53028858

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.632C>T; p.A211V; 13:53043166-53043166

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.786C>T; p.L262L; 13:53050024-53050024

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.15C>T; p.L5L; 13:53028851-53028851

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.364G>T; p.E122*; 13:53041916-53041916

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Nonsense

c.685T>A; p.S229T; 13:53043219-53043219

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1159G>T; p.V387L; 13:53050397-53050397

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.238C>T; p.R80C; 13:53034381-53034381

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.238C>T; p.R80C; 13:53034381-53034381

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.889G>A; p.G297R; 13:53050127-53050127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.34C>T; p.L12L; 13:53028870-53028870

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1404C>G; p.D468E; 13:53050642-53050642

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1495C>T; p.L499L; 13:53050733-53050733

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.978C>T; p.G326G; 13:53050216-53050216

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.931G>A; p.D311N; 13:53050169-53050169

 skinmalignant_melanomaSubstitution - Missense

c.585T>C; p.T195T; 13:53043119-53043119

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.423T>A; p.I141I; 13:53041975-53041975

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.348_349delAC; p.E116fs*12; 13:53034491-53034492

 pancreascarcinoma; ductal_carcinomaDeletion - Frameshift

c.1275G>T; p.Q425H; 13:53050513-53050513

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1300T>C; p.F434L; 13:53050538-53050538

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1464G>A; p.Q488Q; 13:53050702-53050702

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.77G>T; p.G26V; 13:53028913-53028913

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.962T>C; p.L321S; 13:53050200-53050200

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1454C>A; p.P485H; 13:53050692-53050692

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.213C>T; p.S71S; 13:53034356-53034356

 skinmalignant_melanomaSubstitution - coding silent

c.1061C>A; p.T354N; 13:53050299-53050299

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1515C>A; p.V505V; 13:53050753-53050753

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.499G>A; p.E167K; 13:53042051-53042051

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1132G>A; p.V378I; 13:53050370-53050370

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1092C>T; p.L364L; 13:53050330-53050330

 skinmalignant_melanomaSubstitution - coding silent

c.1346G>A; p.R449K; 13:53050584-53050584

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1525delC; p.Q510fs?; 13:53050763-53050763

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; myelofibrosisDeletion - Frameshift

c.354C>T; p.S118S; 13:53034497-53034497

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1001A>G; p.Y334C; 13:53050239-53050239

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.735C>A; p.S245R; 13:53049973-53049973

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.822G>A; p.W274*; 13:53050060-53050060

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.36G>C; p.L12L; 13:53028872-53028872

 kidneyother; neoplasmSubstitution - coding silent

c.155C>A; p.S52*; 13:53028991-53028991

 oesophaguscarcinomaSubstitution - Nonsense

c.10G>T; p.G4C; 13:53028846-53028846

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.10G>T; p.G4C; 13:53028846-53028846

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.843G>T; p.Q281H; 13:53050081-53050081

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1114C>A; p.R372S; 13:53050352-53050352

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1516T>A; p.L506M; 13:53050754-53050754

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1114C>A; p.R372S; 13:53050352-53050352

 pancreascarcinomaSubstitution - Missense

c.1114C>A; p.R372S; 13:53050352-53050352

 pancreascarcinomaSubstitution - Missense

c.1114C>A; p.R372S; 13:53050352-53050352

 breastcarcinomaSubstitution - Missense

c.956G>A; p.R319Q; 13:53050194-53050194

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1217T>C; p.V406A; 13:53050455-53050455

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.116G>T; p.G39V; 13:53028952-53028952

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.648C>T; p.I216I; 13:53043182-53043182

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.586C>A; p.L196I; 13:53043120-53043120

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.293G>A; p.R98K; 13:53034436-53034436

 skinmalignant_melanomaSubstitution - Missense

c.47G>T; p.G16V; 13:53028883-53028883

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.145A>T; p.S49C; 13:53028981-53028981

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.203A>T; p.Q68L; 13:53029039-53029039

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1096A>T; p.N366Y; 13:53050334-53050334

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.364G>A; p.E122K; 13:53041916-53041916

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.965G>A; p.R322Q; 13:53050203-53050203

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.903G>C; p.E301D; 13:53050141-53050141

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.709G>A; p.V237I; 13:53043243-53043243

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.60G>A; p.G20G; 13:53028896-53028896

 skinmalignant_melanomaSubstitution - coding silent

c.96C>T; p.P32P; 13:53028932-53028932

 breastcarcinomaSubstitution - coding silent

c.533G>A; p.G178D; 13:53042085-53042085

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.89C>T; p.P30L; 13:53028925-53028925

 skinmalignant_melanomaSubstitution - Missense

c.1182T>A; p.V394V; 13:53050420-53050420

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.964C>A; p.R322R; 13:53050202-53050202

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.803C>T; p.S268F; 13:53050041-53050041

 skinmalignant_melanomaSubstitution - Missense

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