Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10612

Name

TRIM3

Synonymous

tripartite motif containing 3;TRIM3;tripartite motif containing 3

Definition

RING finger protein 97|brain expressed ring finger|brain-expressed RING finger protein|ring finger protein 22|tripartite motif protein TRIM3|tripartite motif-containing 3|tripartite motif-containing protein 3

Position

11p15.5

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.489G>T; p.Q163H; 11:6457722-6457722

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.366G>A; p.T122T; 11:6457845-6457845

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.615C>T; p.F205F; 11:6457377-6457377

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.615C>T; p.F205F; 11:6457377-6457377

 skinmalignant_melanomaSubstitution - coding silent

c.380G>A; p.C127Y; 11:6457831-6457831

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1125G>A; p.P375P; 11:6456601-6456601

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - coding silent

c.916C>T; p.R306W; 11:6456810-6456810

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.916C>T; p.R306W; 11:6456810-6456810

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1480G>A; p.A494T; 11:6456125-6456125

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1576C>T; p.R526*; 11:6451396-6451396

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1576C>T; p.R526*; 11:6451396-6451396

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1576C>T; p.R526*; 11:6451396-6451396

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1576C>T; p.R526*; 11:6451396-6451396

 skinmalignant_melanomaSubstitution - Nonsense

c.548T>C; p.V183A; 11:6457444-6457444

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.479C>T; p.A160V; 11:6457732-6457732

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.82C>T; p.R28W; 11:6465614-6465614

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.626A>T; p.E209V; 11:6457366-6457366

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.82C>T; p.R28W; 11:6465614-6465614

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1543A>C; p.N515H; 11:6451429-6451429

 breastcarcinomaSubstitution - Missense

c.726C>T; p.R242R; 11:6457000-6457000

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1543A>C; p.N515H; 11:6451429-6451429

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1543A>C; p.N515H; 11:6451429-6451429

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1108_1109insG; p.D370fs*18; 11:6456617-6456618

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1284G>A; p.P428P; 11:6456442-6456442

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1594C>A; p.Q532K; 11:6451378-6451378

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1531C>T; p.Q511*; 11:6456074-6456074

 skinmalignant_melanomaSubstitution - Nonsense

c.270G>A; p.Q90Q; 11:6458158-6458158

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1310C>T; p.S437F; 11:6456416-6456416

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.1310C>T; p.S437F; 11:6456416-6456416

 skinmalignant_melanomaSubstitution - Missense

c.1229G>T; p.R410L; 11:6456497-6456497

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.635T>C; p.L212P; 11:6457357-6457357

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.159G>C; p.Q53H; 11:6458269-6458269

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.420C>G; p.A140A; 11:6457791-6457791

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.795G>A; p.P265P; 11:6456931-6456931

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.2088C>G; p.F696L; 11:6449175-6449175

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1988G>C; p.G663A; 11:6449400-6449400

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.747C>T; p.G249G; 11:6456979-6456979

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1310C>A; p.S437Y; 11:6456416-6456416

 skin; extremitymalignant_melanomaSubstitution - Missense

c.386C>A; p.A129D; 11:6457825-6457825

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1989C>T; p.G663G; 11:6449399-6449399

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1392G>A; p.K464K; 11:6456334-6456334

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.619G>A; p.D207N; 11:6457373-6457373

 livercarcinomaSubstitution - Missense

c.619G>A; p.D207N; 11:6457373-6457373

 livercarcinomaSubstitution - Missense

c.643C>T; p.R215C; 11:6457349-6457349

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.491G>A; p.R164H; 11:6457720-6457720

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1816G>T; p.G606C; 11:6450946-6450946

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.932A>G; p.N311S; 11:6456794-6456794

 skinmalignant_melanomaSubstitution - Missense

c.1682C>T; p.S561F; 11:6451290-6451290

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.517T>A; p.L173M; 11:6457475-6457475

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2168C>T; p.S723L; 11:6449095-6449095

 thyroidother; neoplasmSubstitution - Missense

c.1454A>G; p.E485G; 11:6456151-6456151

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1971C>G; p.F657L; 11:6449417-6449417

 breastcarcinomaSubstitution - Missense

c.1041C>T; p.T347T; 11:6456685-6456685

 skinmalignant_melanomaSubstitution - coding silent

c.2169G>A; p.S723S; 11:6449094-6449094

 prostatecarcinomaSubstitution - coding silent

c.1436G>A; p.R479H; 11:6456169-6456169

 breastcarcinomaSubstitution - Missense

c.1436G>A; p.R479H; 11:6456169-6456169

 breastcarcinomaSubstitution - Missense

c.1436G>A; p.R479H; 11:6456169-6456169

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1845T>C; p.R615R; 11:6450917-6450917

 bone; tibiaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1811C>A; p.P604H; 11:6450951-6450951

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1110C>T; p.D370D; 11:6456616-6456616

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1767C>G; p.I589M; 11:6450995-6450995

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.603C>T; p.I201I; 11:6457389-6457389

 thyroidother; neoplasmSubstitution - coding silent

c.2015C>T; p.P672L; 11:6449373-6449373

 skinmalignant_melanomaSubstitution - Missense

c.1229G>A; p.R410H; 11:6456497-6456497

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1022C>T; p.A341V; 11:6456704-6456704

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1067G>A; p.R356H; 11:6456659-6456659

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.385G>T; p.A129S; 11:6457826-6457826

 central_nervous_system; brainglioma; astrocytoma_Grade_IIISubstitution - Missense

c.759C>A; p.S253R; 11:6456967-6456967

 large_intestineadenomaSubstitution - Missense

c.1106C>T; p.P369L; 11:6456620-6456620

 pancreascarcinomaSubstitution - Missense

c.1106C>T; p.P369L; 11:6456620-6456620

 pancreascarcinomaSubstitution - Missense

c.2144G>T; p.G715V; 11:6449119-6449119

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1215C>T; p.Y405Y; 11:6456511-6456511

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1541C>G; p.S514C; 11:6451431-6451431

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1533+1G>A; p.?; 11:6456071-6456071

 skinmalignant_melanomaUnknown

c.1014C>T; p.G338G; 11:6456712-6456712

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1107G>A; p.P369P; 11:6456619-6456619

 skinmalignant_melanomaSubstitution - coding silent

c.490C>T; p.R164C; 11:6457721-6457721

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1917G>A; p.T639T; 11:6450575-6450575

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1111G>A; p.G371S; 11:6456615-6456615

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.243C>T; p.F81F; 11:6458185-6458185

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1111G>A; p.G371S; 11:6456615-6456615

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.786C>A; p.G262G; 11:6456940-6456940

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.450G>T; p.L150L; 11:6457761-6457761

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1849G>A; p.A617T; 11:6450913-6450913

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.663C>T; p.S221S; 11:6457329-6457329

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.670G>A; p.E224K; 11:6457322-6457322

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1146G>T; p.K382N; 11:6456580-6456580

 breastcarcinomaSubstitution - Missense

c.2099G>A; p.G700D; 11:6449164-6449164

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.919C>G; p.R307G; 11:6456807-6456807

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1102G>A; p.G368S; 11:6456624-6456624

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1610C>G; p.T537R; 11:6451362-6451362

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.83G>A; p.R28Q; 11:6465613-6465613

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1280C>T; p.S427F; 11:6456446-6456446

 skinmalignant_melanomaSubstitution - Missense

c.187C>T; p.R63W; 11:6458241-6458241

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2207G>A; p.C736Y; 11:6449056-6449056

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2207G>A; p.C736Y; 11:6449056-6449056

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.2207G>A; p.C736Y; 11:6449056-6449056

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1579G>T; p.G527*; 11:6451393-6451393

 lungcarcinoma; small_cell_carcinomaSubstitution - Nonsense

c.365C>T; p.T122M; 11:6457846-6457846

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1259G>A; p.R420H; 11:6456467-6456467

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2088C>T; p.F696F; 11:6449175-6449175

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.746G>A; p.G249D; 11:6456980-6456980

 skin; handcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1421delT; p.F474fs*29; 11:6456305-6456305

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1380C>T; p.G460G; 11:6456346-6456346

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1380C>T; p.G460G; 11:6456346-6456346

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1732C>T; p.P578S; 11:6451030-6451030

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1380C>T; p.G460G; 11:6456346-6456346

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1380C>T; p.G460G; 11:6456346-6456346

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.168G>A; p.T56T; 11:6458260-6458260

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2002C>T; p.Q668*; 11:6449386-6449386

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.2088C>A; p.F696L; 11:6449175-6449175

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.2081A>T; p.Q694L; 11:6449307-6449307

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.217G>A; p.V73I; 11:6458211-6458211

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1963T>A; p.F655I; 11:6449425-6449425

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2131G>A; p.E711K; 11:6449132-6449132

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.974C>T; p.T325M; 11:6456752-6456752

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.924G>A; p.S308S; 11:6456802-6456802

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.12G>A; p.R4R; 11:6465684-6465684

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1563C>T; p.F521F; 11:6451409-6451409

 skinmalignant_melanomaSubstitution - coding silent

c.291C>T; p.H97H; 11:6458137-6458137

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.788C>T; p.S263L; 11:6456938-6456938

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1565G>A; p.R522H; 11:6451407-6451407

 prostatecarcinomaSubstitution - Missense

c.1168T>C; p.Y390H; 11:6456558-6456558

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.705A>T; p.Q235H; 11:6457021-6457021

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1336C>T; p.R446C; 11:6456390-6456390

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1831C>T; p.R611C; 11:6450931-6450931

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1851C>T; p.A617A; 11:6450911-6450911

 skinmalignant_melanomaSubstitution - coding silent

c.1629C>T; p.T543T; 11:6451343-6451343

 skinmalignant_melanomaSubstitution - coding silent

c.330C>G; p.G110G; 11:6458098-6458098

 thyroidother; neoplasmSubstitution - coding silent

c.330C>G; p.G110G; 11:6458098-6458098

 thyroidother; neoplasmSubstitution - coding silent

c.330C>G; p.G110G; 11:6458098-6458098

 thyroidother; neoplasmSubstitution - coding silent

c.330C>G; p.G110G; 11:6458098-6458098

 thyroidother; neoplasmSubstitution - coding silent

c.724C>T; p.R242C; 11:6457002-6457002

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1874C>T; p.P625L; 11:6450618-6450618

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.114G>A; p.L38L; 11:6465582-6465582

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.1120C>T; p.L374F; 11:6456606-6456606

 skinmalignant_melanomaSubstitution - Missense

c.189G>A; p.R63R; 11:6458239-6458239

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.219C>A; p.V73V; 11:6458209-6458209

 breastcarcinomaSubstitution - coding silent

c.132A>C; p.R44S; 11:6458296-6458296

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2222G>A; p.R741H; 11:6449041-6449041

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.2136A>G; p.P712P; 11:6449127-6449127

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1422C>T; p.F474F; 11:6456304-6456304

 skinmalignant_melanomaSubstitution - coding silent

c.1423C>T; p.R475C; 11:6456303-6456303

 skinmalignant_melanomaSubstitution - Missense

c.1416C>T; p.L472L; 11:6456310-6456310

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1416C>T; p.L472L; 11:6456310-6456310

 skinmalignant_melanomaSubstitution - coding silent

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