Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10633

Name

RASL10A

Synonymous

RAS-like, family 10, member A;RASL10A;RAS-like, family 10, member A

Definition

ras-like protein RRP22|ras-like protein family member 10A|ras-related protein on chromosome 22

Position

22q12.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.347C>T; p.P116L; 22:29313566-29313566

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.594G>A; p.A198A; 22:29313319-29313319

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.393G>A; p.R131R; 22:29313520-29313520

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.361G>A; p.E121K; 22:29313552-29313552

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.357G>A; p.A119A; 22:29313556-29313556

 livercarcinomaSubstitution - coding silent

c.357G>A; p.A119A; 22:29313556-29313556

 livercarcinomaSubstitution - coding silent

c.264C>T; p.A88A; 22:29313943-29313943

 skinmalignant_melanomaSubstitution - coding silent

c.309C>T; p.Y103Y; 22:29313898-29313898

 central_nervous_system; braingliomaSubstitution - coding silent

c.243G>C; p.W81C; 22:29313964-29313964

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.299G>T; p.S100I; 22:29313908-29313908

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.119G>C; p.R40P; 22:29315128-29315128

 NSNSSubstitution - Missense

c.428C>T; p.A143V; 22:29313485-29313485

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.445C>T; p.R149C; 22:29313468-29313468

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.331_332insGCGCA; p.I111fs*19; 22:29313875-29313876

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.145G>T; p.D49Y; 22:29315102-29315102

 lungcarcinoma; adenocarcinomaSubstitution - Missense

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