Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10769

Name

PLK2

Synonymous

polo-like kinase 2;PLK2;polo-like kinase 2

Definition

PLK-2|serine/threonine-protein kinase PLK2|serine/threonine-protein kinase SNK|serum-inducible kinase

Position

5q12.1-q13.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.20.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.378+5G>C; p.?; 5:58458980-58458980

 ovarycarcinoma; serous_carcinomaUnknown

c.378+5G>C; p.?; 5:58458980-58458980

 ovarycarcinoma; serous_carcinomaUnknown

c.1810C>T; p.Q604*; 5:58454967-58454967

 breastcarcinomaSubstitution - Nonsense

c.837A>G; p.P279P; 5:58457352-58457352

 bone; pelvisEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1883A>G; p.D628G; 5:58454758-58454758

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.84G>A; p.G28G; 5:58459876-58459876

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.84G>A; p.G28G; 5:58459876-58459876

 thyroidother; neoplasmSubstitution - coding silent

c.1534A>G; p.N512D; 5:58455630-58455630

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.36C>T; p.A12A; 5:58459924-58459924

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.989G>A; p.R330Q; 5:58457200-58457200

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1102G>A; p.A368T; 5:58456999-58456999

 boneosteosarcomaSubstitution - Missense

c.707G>T; p.R236I; 5:58458090-58458090

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1856G>T; p.G619V; 5:58454921-58454921

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1188C>T; p.Y396Y; 5:58456558-58456558

 breastcarcinomaSubstitution - coding silent

c.1337G>A; p.R446Q; 5:58456073-58456073

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.121G>A; p.E41K; 5:58459839-58459839

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1337G>A; p.R446Q; 5:58456073-58456073

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1003_1004delTT; p.L335fs*11; 5:58457185-58457186

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1438C>T; p.R480W; 5:58455726-58455726

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1070C>G; p.S357*; 5:58457031-58457031

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1709C>T; p.T570M; 5:58455331-58455331

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1340T>A; p.M447K; 5:58456070-58456070

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1699A>G; p.S567G; 5:58455341-58455341

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1018C>A; p.P340T; 5:58457083-58457083

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.626-7C>T; p.?; 5:58458178-58458178

 livercarcinoma; hepatocellular_carcinomaUnknown

c.626-7C>T; p.?; 5:58458178-58458178

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.1470T>C; p.D490D; 5:58455694-58455694

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.689T>A; p.L230Q; 5:58458108-58458108

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1126A>C; p.K376Q; 5:58456975-58456975

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1089C>A; p.F363L; 5:58457012-58457012

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1089C>A; p.F363L; 5:58457012-58457012

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1089C>A; p.F363L; 5:58457012-58457012

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.117_118insC; p.E40fs*66; 5:58459842-58459843

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.920C>T; p.A307V; 5:58457269-58457269

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1289C>T; p.S430F; 5:58456121-58456121

 thyroidcarcinomaSubstitution - Missense

c.117C>T; p.P39P; 5:58459843-58459843

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1393G>A; p.D465N; 5:58455771-58455771

 skinmalignant_melanomaSubstitution - Missense

c.867T>C; p.Y289Y; 5:58457322-58457322

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2007A>T; p.L669F; 5:58454634-58454634

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 stomachadenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestine; colonNSDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1004delT; p.L335fs*68; 5:58457185-58457185

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.276C>T; p.G92G; 5:58459087-58459087

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1004delT; p.L335fs*68; 5:58457185-58457185

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1955C>T; p.S652F; 5:58454686-58454686

 skinmalignant_melanomaSubstitution - Missense

c.1336C>T; p.R446W; 5:58456074-58456074

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1336C>T; p.R446W; 5:58456074-58456074

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1336C>T; p.R446W; 5:58456074-58456074

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2038C>T; p.L680F; 5:58454603-58454603

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1654C>A; p.Q552K; 5:58455386-58455386

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1696A>G; p.I566V; 5:58455344-58455344

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.328G>A; p.A110T; 5:58459035-58459035

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.328G>A; p.A110T; 5:58459035-58459035

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.734A>T; p.N245I; 5:58457563-58457563

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1468G>C; p.D490H; 5:58455696-58455696

 breastcarcinomaSubstitution - Missense

c.328G>A; p.A110T; 5:58459035-58459035

 prostatecarcinomaSubstitution - Missense

c.1004_1005insT; p.L335fs*12; 5:58457184-58457185

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaInsertion - Frameshift

c.1004_1005insT; p.L335fs*12; 5:58457184-58457185

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1004_1005insT; p.L335fs*12; 5:58457184-58457185

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.1019C>T; p.P340L; 5:58457082-58457082

 skin; upper_armmalignant_melanomaSubstitution - Missense

c.237G>A; p.G79G; 5:58459723-58459723

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.535G>A; p.E179K; 5:58458489-58458489

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1548T>C; p.F516F; 5:58455616-58455616

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1858A>G; p.T620A; 5:58454919-58454919

 skinmalignant_melanomaSubstitution - Missense

c.623T>C; p.L208P; 5:58458401-58458401

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1365C>G; p.S455R; 5:58456045-58456045

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1847T>A; p.F616Y; 5:58454930-58454930

 skinmalignant_melanomaSubstitution - Missense

c.2043A>T; p.L681F; 5:58454598-58454598

 breastcarcinomaSubstitution - Missense

c.647C>T; p.A216V; 5:58458150-58458150

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.892A>G; p.T298A; 5:58457297-58457297

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.7C>G; p.L3V; 5:58459953-58459953

 pancreascarcinomaSubstitution - Missense

c.1786C>T; p.R596*; 5:58454991-58454991

 skinmalignant_melanomaSubstitution - Nonsense

c.1786C>T; p.R596*; 5:58454991-58454991

 skinmalignant_melanomaSubstitution - Nonsense

c.1756-2A>G; p.?; 5:58455023-58455023

 lungcarcinoma; adenocarcinomaUnknown

c.784G>A; p.D262N; 5:58457513-58457513

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1756G>T; p.G586C; 5:58455021-58455021

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1777A>T; p.T593S; 5:58455000-58455000

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.117delC; p.E40fs*60; 5:58459843-58459843

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.268A>G; p.K90E; 5:58459692-58459692

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2046_2051delAAGATG; p.Q682_C684>H; 5:58454590-58454595

 breastcarcinomaComplex - deletion inframe

c.1573G>A; p.V525I; 5:58455591-58455591

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1813T>G; p.W605G; 5:58454964-58454964

 skinmalignant_melanomaSubstitution - Missense

c.1478C>T; p.P493L; 5:58455686-58455686

 skinmalignant_melanomaSubstitution - Missense

c.2014C>T; p.R672*; 5:58454627-58454627

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.2014C>T; p.R672*; 5:58454627-58454627

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.296T>C; p.M99T; 5:58459067-58459067

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.108G>A; p.P36P; 5:58459852-58459852

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1839G>T; p.M613I; 5:58454938-58454938

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1637A>G; p.Y546C; 5:58455403-58455403

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1637A>G; p.Y546C; 5:58455403-58455403

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1900_1902delATC; p.I634delI; 5:58454739-58454741

 breastcarcinomaDeletion - In frame

c.1023C>A; p.D341E; 5:58457078-58457078

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1493G>T; p.S498I; 5:58455671-58455671

 central_nervous_system; brainglioma; astrocytoma_Grade_IIISubstitution - Missense

c.378+4C>T; p.?; 5:58458981-58458981

 livercarcinoma; hepatocellular_carcinomaUnknown

c.141C>T; p.S47S; 5:58459819-58459819

 skinmalignant_melanomaSubstitution - coding silent

c.469A>G; p.I157V; 5:58458751-58458751

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.64C>T; p.L22L; 5:58459896-58459896

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.1575C>T; p.V525V; 5:58455589-58455589

 skinmalignant_melanomaSubstitution - coding silent

c.1907G>A; p.S636N; 5:58454734-58454734

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1387C>A; p.L463I; 5:58455777-58455777

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1020G>C; p.P340P; 5:58457081-58457081

 livercarcinomaSubstitution - coding silent

c.1020G>C; p.P340P; 5:58457081-58457081

 livercarcinomaSubstitution - coding silent

c.284A>C; p.K95T; 5:58459079-58459079

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1795C>T; p.R599W; 5:58454982-58454982

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.274G>T; p.G92C; 5:58459089-58459089

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.274G>T; p.G92C; 5:58459089-58459089

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.246C>A; p.Y82*; 5:58459714-58459714

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1054C>T; p.P352S; 5:58457047-58457047

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.245A>T; p.Y82F; 5:58459715-58459715

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.274G>A; p.G92S; 5:58459089-58459089

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.274G>A; p.G92S; 5:58459089-58459089

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.900G>A; p.P300P; 5:58457289-58457289

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.727A>G; p.T243A; 5:58457570-58457570

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1034C>A; p.S345Y; 5:58457067-58457067

 breastcarcinomaSubstitution - Missense

c.1950G>T; p.R650S; 5:58454691-58454691

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.1171G>T; p.E391*; 5:58456575-58456575

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.140C>T; p.S47F; 5:58459820-58459820

 skinmalignant_melanomaSubstitution - Missense

c.1142A>G; p.Y381C; 5:58456959-58456959

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1577G>A; p.G526D; 5:58455587-58455587

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.122A>T; p.E41V; 5:58459838-58459838

 livercarcinomaSubstitution - Missense

c.122A>T; p.E41V; 5:58459838-58459838

 livercarcinomaSubstitution - Missense

c.122A>T; p.E41V; 5:58459838-58459838

 livercarcinomaSubstitution - Missense

c.1153C>T; p.H385Y; 5:58456948-58456948

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.637A>G; p.I213V; 5:58458160-58458160

 livercarcinomaSubstitution - Missense

c.637A>G; p.I213V; 5:58458160-58458160

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1576G>C; p.G526R; 5:58455588-58455588

 breastcarcinomaSubstitution - Missense

c.121G>T; p.E41*; 5:58459839-58459839

 livercarcinomaSubstitution - Nonsense

c.1214C>T; p.T405I; 5:58456532-58456532

 skin; trunkmalignant_melanomaSubstitution - Missense

c.121G>T; p.E41*; 5:58459839-58459839

 livercarcinomaSubstitution - Nonsense

c.121G>T; p.E41*; 5:58459839-58459839

 livercarcinomaSubstitution - Nonsense

c.292G>C; p.E98Q; 5:58459071-58459071

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1064A>T; p.H355L; 5:58457037-58457037

 skinmalignant_melanomaSubstitution - Missense

c.339T>C; p.I113I; 5:58459024-58459024

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1227G>A; p.Q409Q; 5:58456519-58456519

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1865A>T; p.Q622L; 5:58454912-58454912

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.41G>C; p.S14T; 5:58459919-58459919

 ovarycarcinoma; endometrioid_carcinomaSubstitution - Missense

c.41G>C; p.S14T; 5:58459919-58459919

 ovarycarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1733A>G; p.Y578C; 5:58455307-58455307

 livercarcinomaSubstitution - Missense

c.1733A>G; p.Y578C; 5:58455307-58455307

 livercarcinomaSubstitution - Missense

c.965G>A; p.R322H; 5:58457224-58457224

 prostatecarcinomaSubstitution - Missense

c.622C>G; p.L208V; 5:58458402-58458402

 breastcarcinomaSubstitution - Missense

c.1998A>G; p.S666S; 5:58454643-58454643

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1477C>T; p.P493S; 5:58455687-58455687

 skinmalignant_melanomaSubstitution - Missense

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