Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

11074

Name

TRIM31

Synonymous

tripartite motif containing 31;TRIM31;tripartite motif containing 31

Definition

E3 ubiquitin-protein ligase TRIM31|ring finger protein|tripartite motif-containing 31 gamma|tripartite motif-containing protein 31

Position

6p21.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

Top

There is no record for TRIM31

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.12G>A; p.G4G; 6:30112794-30112794

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.869_870insG; p.F293fs*8; 6:30108066-30108067

 lungcarcinoma; adenocarcinomaInsertion - Frameshift

c.862G>A; p.G288R; 6:30108074-30108074

 skinmalignant_melanomaSubstitution - Missense

c.1190A>G; p.D397G; 6:30103624-30103624

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.50C>T; p.P17L; 6:30112756-30112756

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.642G>A; p.G214G; 6:30110550-30110550

 skinmalignant_melanomaSubstitution - coding silent

c.642G>A; p.G214G; 6:30110550-30110550

 skinmalignant_melanomaSubstitution - coding silent

c.564G>A; p.L188L; 6:30110628-30110628

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.642G>A; p.G214G; 6:30110550-30110550

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.487G>A; p.G163S; 6:30111674-30111674

 livercarcinomaSubstitution - Missense

c.487G>A; p.G163S; 6:30111674-30111674

 livercarcinomaSubstitution - Missense

c.655G>A; p.A219T; 6:30110537-30110537

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.439C>T; p.Q147*; 6:30111722-30111722

 skinmalignant_melanomaSubstitution - Nonsense

c.855C>T; p.S285S; 6:30108081-30108081

 skinmalignant_melanomaSubstitution - coding silent

c.756C>T; p.V252V; 6:30109037-30109037

 skinmalignant_melanomaSubstitution - coding silent

c.616C>T; p.L206L; 6:30110576-30110576

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1238C>T; p.T413I; 6:30103576-30103576

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.726A>G; p.P242P; 6:30110466-30110466

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.375C>T; p.S125S; 6:30112431-30112431

 skinmalignant_melanomaSubstitution - coding silent

c.269G>A; p.R90K; 6:30112537-30112537

 skinmalignant_melanomaSubstitution - Missense

c.31C>A; p.Q11K; 6:30112775-30112775

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.960G>A; p.W320*; 6:30104166-30104166

 skinmalignant_melanomaSubstitution - Nonsense

c.270G>A; p.R90R; 6:30112536-30112536

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.853T>G; p.S285A; 6:30108083-30108083

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.853T>G; p.S285A; 6:30108083-30108083

 livercarcinomaSubstitution - Missense

c.1011G>A; p.G337G; 6:30104115-30104115

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.301A>C; p.M101L; 6:30112505-30112505

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.31delC; p.Q11fs*4; 6:30112775-30112775

 lungcarcinoma; small_cell_carcinomaDeletion - Frameshift

c.742G>A; p.E248K; 6:30110450-30110450

 skinmalignant_melanomaSubstitution - Missense

c.178G>A; p.V60I; 6:30112628-30112628

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1141G>A; p.D381N; 6:30103673-30103673

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.781C>A; p.Q261K; 6:30108155-30108155

 skinmalignant_melanomaSubstitution - Missense

c.800C>T; p.P267L; 6:30108136-30108136

 skinmalignant_melanomaSubstitution - Missense

c.352C>T; p.R118C; 6:30112454-30112454

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.610T>G; p.Y204D; 6:30110582-30110582

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.307C>T; p.H103Y; 6:30112499-30112499

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1093T>G; p.S365A; 6:30103721-30103721

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1236G>A; p.L412L; 6:30103578-30103578

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.460_462delAAG; p.K154delK; 6:30111699-30111701

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.1026C>T; p.G342G; 6:30103788-30103788

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1204G>A; p.E402K; 6:30103610-30103610

 salivary_gland; parotidcarcinoma; adenoid_cystic_carcinomaSubstitution - Missense

c.1118C>T; p.P373L; 6:30103696-30103696

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.637G>A; p.A213T; 6:30110555-30110555

 skin; trunkmalignant_melanomaSubstitution - Missense

c.729C>T; p.P243P; 6:30110463-30110463

 lungcarcinomaSubstitution - coding silent

c.193A>C; p.I65L; 6:30112613-30112613

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.740T>G; p.L247R; 6:30110452-30110452

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.13C>A; p.Q5K; 6:30112793-30112793

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.193A>G; p.I65V; 6:30112613-30112613

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.723G>A; p.M241I; 6:30110469-30110469

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1100C>A; p.A367D; 6:30103714-30103714

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.98A>C; p.H33P; 6:30112708-30112708

 skinmalignant_melanomaSubstitution - Missense

c.300G>A; p.E100E; 6:30112506-30112506

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.423G>A; p.Q141Q; 6:30111738-30111738

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.574C>T; p.L192L; 6:30110618-30110618

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1042G>A; p.G348R; 6:30103772-30103772

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.539G>T; p.R180M; 6:30110653-30110653

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.454A>C; p.K152Q; 6:30111707-30111707

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.364G>A; p.D122N; 6:30112442-30112442

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.849T>C; p.H283H; 6:30108087-30108087

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.638C>T; p.A213V; 6:30110554-30110554

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.435G>A; p.Q145Q; 6:30111726-30111726

 bone; femurchondrosarcomaSubstitution - coding silent

c.810G>A; p.L270L; 6:30108126-30108126

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.88G>A; p.D30N; 6:30112718-30112718

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.305T>A; p.F102Y; 6:30112501-30112501

 skinmalignant_melanomaSubstitution - Missense

c.162C>T; p.P54P; 6:30112644-30112644

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.992A>T; p.N331I; 6:30104134-30104134

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.598C>A; p.L200I; 6:30110594-30110594

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.177C>T; p.S59S; 6:30112629-30112629

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.728C>T; p.P243L; 6:30110464-30110464

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.728C>T; p.P243L; 6:30110464-30110464

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1152T>C; p.S384S; 6:30103662-30103662

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.438C>T; p.I146I; 6:30111723-30111723

 skinmalignant_melanomaSubstitution - coding silent

c.1062T>A; p.S354S; 6:30103752-30103752

 skinmalignant_melanomaSubstitution - coding silent

c.903G>A; p.R301R; 6:30105223-30105223

 skin; head_neckmalignant_melanoma; superficial_spreadingSubstitution - coding silent

c.903G>A; p.R301R; 6:30105223-30105223

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.918C>G; p.N306K; 6:30105208-30105208

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.791A>G; p.N264S; 6:30108145-30108145

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.876delA; p.K292fs*21; 6:30108060-30108060

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1261G>A; p.E421K; 6:30103553-30103553

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.520G>A; p.V174I; 6:30110672-30110672

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.520G>A; p.V174I; 6:30110672-30110672

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.30G>A; p.L10L; 6:30112776-30112776

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

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