Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

11145

Name

PLA2G16

Synonymous

phospholipase A2, group XVI;PLA2G16;phospholipase A2, group XVI

Definition

Ca-independent phospholipase A1/2|H-rev 107 protein homolog|HRAS-like suppressor 1|HRAS-like suppressor 3|adipose-specific PLA2|adipose-specific phospholipase A2|group XVI phospholipase A1/A2|group XVI phospholipase A2|renal carcinoma antigen NY-REN-65

Position

11q12.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.402C>G; p.I134M; 11:63575032-63575032

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.126C>T; p.V42V; 11:63590361-63590361

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.126C>T; p.V42V; 11:63590361-63590361

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.257C>T; p.P86L; 11:63590230-63590230

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.220T>C; p.Y74H; 11:63590267-63590267

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.92G>A; p.G31E; 11:63598087-63598087

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.183G>T; p.K61N; 11:63590304-63590304

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.29C>T; p.P10L; 11:63598150-63598150

 skinmalignant_melanomaSubstitution - Missense

c.139G>A; p.A47T; 11:63590348-63590348

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.377G>A; p.R126H; 11:63590110-63590110

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.285G>A; p.R95R; 11:63590202-63590202

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.338G>A; p.C113Y; 11:63590149-63590149

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.156C>T; p.S52S; 11:63590331-63590331

 NSmalignant_melanomaSubstitution - coding silent

c.284G>A; p.R95Q; 11:63590203-63590203

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.156C>T; p.S52S; 11:63590331-63590331

 NSmalignant_melanomaSubstitution - coding silent

c.326C>T; p.T109I; 11:63590161-63590161

 skin; trunkmalignant_melanomaSubstitution - Missense

c.206C>T; p.A69V; 11:63590281-63590281

 skinmalignant_melanomaSubstitution - Missense

c.32G>A; p.G11E; 11:63598147-63598147

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.477A>G; p.R159R; 11:63574957-63574957

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.54C>T; p.R18R; 11:63598125-63598125

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.54C>T; p.R18R; 11:63598125-63598125

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.283C>T; p.R95W; 11:63590204-63590204

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.276C>T; p.I92I; 11:63590211-63590211

 skinmalignant_melanomaSubstitution - coding silent

c.476G>A; p.R159Q; 11:63574958-63574958

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.178G>A; p.V60M; 11:63590309-63590309

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.8C>T; p.A3V; 11:63614007-63614007

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.254C>T; p.S85L; 11:63590233-63590233

 skinmalignant_melanomaSubstitution - Missense

c.141A>G; p.A47A; 11:63590346-63590346

 skinmalignant_melanomaSubstitution - coding silent

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