Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

11197

Name

WIF1

Synonymous

WNT inhibitory factor 1;WIF1;WNT inhibitory factor 1

Definition

wnt inhibitory factor 1

Position

12q14.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.552C>T; p.G184G; 12:65067777-65067777

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.931G>A; p.E311K; 12:65055205-65055205

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.559C>T; p.R187*; 12:65067770-65067770

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1098C>A; p.A366A; 12:65051391-65051391

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.708C>A; p.F236L; 12:65066663-65066663

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.482G>A; p.G161D; 12:65068820-65068820

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.762G>A; p.G254G; 12:65062545-65062545

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.313T>C; p.S105P; 12:65077830-65077830

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.731-3C>A; p.?; 12:65062579-65062579

 oesophaguscarcinoma; adenocarcinomaUnknown

c.439G>T; p.V147L; 12:65068863-65068863

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.288+1G>C; p.?; 12:65120416-65120416

 ovarycarcinoma; serous_carcinomaUnknown

c.374G>A; p.G125E; 12:65077769-65077769

 skinmalignant_melanomaSubstitution - Missense

c.1024G>A; p.E342K; 12:65051465-65051465

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1024G>A; p.E342K; 12:65051465-65051465

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1091A>G; p.K364R; 12:65051398-65051398

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.163A>G; p.I55V; 12:65120542-65120542

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.242C>T; p.P81L; 12:65120463-65120463

 skinmalignant_melanomaSubstitution - Missense

c.591C>G; p.I197M; 12:65067738-65067738

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.304G>A; p.E102K; 12:65077839-65077839

 skinmalignant_melanomaSubstitution - Missense

c.637C>A; p.L213I; 12:65066734-65066734

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.21C>T; p.F7F; 12:65121171-65121171

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.215A>T; p.K72I; 12:65120490-65120490

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.997C>A; p.H333N; 12:65055139-65055139

 skinmalignant_melanomaSubstitution - Missense

c.446C>A; p.A149E; 12:65068856-65068856

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1078A>G; p.T360A; 12:65051411-65051411

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.602C>T; p.P201L; 12:65067727-65067727

 skinmalignant_melanomaSubstitution - Missense

c.847C>A; p.R283R; 12:65056106-65056106

 livercarcinomaSubstitution - coding silent

c.847C>A; p.R283R; 12:65056106-65056106

 livercarcinomaSubstitution - coding silent

c.896G>T; p.G299V; 12:65056057-65056057

 livercarcinomaSubstitution - Missense

c.820G>A; p.E274K; 12:65062487-65062487

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.204T>C; p.H68H; 12:65120501-65120501

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.587G>A; p.R196H; 12:65067742-65067742

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.587G>A; p.R196H; 12:65067742-65067742

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1124C>T; p.S375F; 12:65051365-65051365

 livercarcinomaSubstitution - Missense

c.1124C>T; p.S375F; 12:65051365-65051365

 livercarcinomaSubstitution - Missense

c.1106G>C; p.R369P; 12:65051383-65051383

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.680C>T; p.P227L; 12:65066691-65066691

 skinmalignant_melanomaSubstitution - Missense

c.1059C>T; p.G353G; 12:65051430-65051430

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.996G>A; p.W332*; 12:65055140-65055140

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.397+1G>A; p.?; 12:65077745-65077745

 ovarycarcinoma; serous_carcinomaUnknown

c.1004G>A; p.R335K; 12:65055132-65055132

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.320G>A; p.R107H; 12:65077823-65077823

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.546C>A; p.C182*; 12:65067783-65067783

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.704G>A; p.G235E; 12:65066667-65066667

 skin; shouldermalignant_melanomaSubstitution - Missense

c.634+1G>A; p.?; 12:65067694-65067694

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.895G>T; p.G299C; 12:65056058-65056058

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.560G>A; p.R187Q; 12:65067769-65067769

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.294A>G; p.E98E; 12:65077849-65077849

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1133T>G; p.I378S; 12:65051356-65051356

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.560G>A; p.R187Q; 12:65067769-65067769

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.650G>A; p.R217Q; 12:65066721-65066721

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.255T>C; p.H85H; 12:65120450-65120450

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.398-2A>T; p.?; 12:65068906-65068906

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.398-2A>T; p.?; 12:65068906-65068906

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.398-2A>T; p.?; 12:65068906-65068906

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.786T>C; p.C262C; 12:65062521-65062521

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.649C>T; p.R217*; 12:65066722-65066722

 central_nervous_system; braingliomaSubstitution - Nonsense

c.565G>A; p.G189R; 12:65067764-65067764

 skinmalignant_melanomaSubstitution - Missense

c.735C>T; p.N245N; 12:65062572-65062572

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.749G>C; p.C250S; 12:65062558-65062558

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.725A>G; p.D242G; 12:65066646-65066646

 central_nervous_system; braingliomaSubstitution - Missense

c.215A>G; p.K72R; 12:65120490-65120490

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.244G>C; p.V82L; 12:65120461-65120461

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.244G>C; p.V82L; 12:65120461-65120461

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.522T>G; p.F174L; 12:65068780-65068780

 skinmalignant_melanomaSubstitution - Missense

c.1116A>G; p.P372P; 12:65051373-65051373

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.250A>G; p.I84V; 12:65120455-65120455

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.309C>A; p.F103L; 12:65077834-65077834

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.854G>A; p.G285E; 12:65056099-65056099

 skinmalignant_melanomaSubstitution - Missense

c.929G>A; p.C310Y; 12:65055207-65055207

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.319C>T; p.R107C; 12:65077824-65077824

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.432G>A; p.Q144Q; 12:65068870-65068870

 skinmalignant_melanomaSubstitution - coding silent

c.520T>C; p.F174L; 12:65068782-65068782

 central_nervous_system; brainglioma; astrocytoma_Grade_IISubstitution - Missense

c.805G>C; p.E269Q; 12:65062502-65062502

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.922C>T; p.P308S; 12:65056031-65056031

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.547C>A; p.P183T; 12:65067782-65067782

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.547C>A; p.P183T; 12:65067782-65067782

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.647C>T; p.P216L; 12:65066724-65066724

 skinmalignant_melanomaSubstitution - Missense

c.693C>G; p.I231M; 12:65066678-65066678

 breastcarcinomaSubstitution - Missense

c.154G>A; p.E52K; 12:65120551-65120551

 breastcarcinomaSubstitution - Missense

c.642T>G; p.C214W; 12:65066729-65066729

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.356T>G; p.V119G; 12:65077787-65077787

 skinmalignant_melanomaSubstitution - Missense

c.323C>T; p.S108F; 12:65077820-65077820

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.415C>T; p.P139S; 12:65068887-65068887

 skinmalignant_melanomaSubstitution - Missense

c.805G>A; p.E269K; 12:65062502-65062502

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

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