Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

11219

Name

TREX2

Synonymous

three prime repair exonuclease 2;TREX2;three prime repair exonuclease 2

Definition

3'-5' exonuclease TREX2 long form

Position

Xq28

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.11.

The copy number variations for various cancers

Top

There is no record for TREX2

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.258G>A; p.A86A; 23:153445173-153445173

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.552A>G; p.P184P; 23:153444879-153444879

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.164G>T; p.R55L; 23:153445267-153445267

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.226G>A; p.E76K; 23:153445205-153445205

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.455G>A; p.R152Q; 23:153444976-153444976

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.324G>A; p.Q108Q; 23:153445107-153445107

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.467G>A; p.R156H; 23:153444964-153444964

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.467G>A; p.R156H; 23:153444964-153444964

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.94C>A; p.L32I; 23:153445337-153445337

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.688G>A; p.D230N; 23:153444743-153444743

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.21C>T; p.A7A; 23:153445410-153445410

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.166G>A; p.V56I; 23:153445265-153445265

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.203G>A; p.R68H; 23:153445228-153445228

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.259C>T; p.R87*; 23:153445172-153445172

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.351_362del12; p.N118_D121delNGFD; 23:153445069-153445080

 livercarcinoma; hepatocellular_carcinomaDeletion - In frame

c.153A>G; p.L51L; 23:153445278-153445278

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.129G>A; p.P43P; 23:153445302-153445302

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.494G>T; p.R165L; 23:153444937-153444937

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.433C>A; p.L145M; 23:153444998-153444998

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.467G>T; p.R156L; 23:153444964-153444964

 breastcarcinomaSubstitution - Missense

c.666C>T; p.I222I; 23:153444765-153444765

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.110G>A; p.R37H; 23:153445321-153445321

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.633G>T; p.W211C; 23:153444798-153444798

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.114C>A; p.S38S; 23:153445317-153445317

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.164G>A; p.R55Q; 23:153445267-153445267

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.198G>T; p.P66P; 23:153445233-153445233

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.225C>T; p.S75S; 23:153445206-153445206

 skinmalignant_melanomaSubstitution - coding silent

c.109C>T; p.R37C; 23:153445322-153445322

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.613G>A; p.A205T; 23:153444818-153444818

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.468C>T; p.R156R; 23:153444963-153444963

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.182C>T; p.T61M; 23:153445249-153445249

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.242G>A; p.S81N; 23:153445189-153445189

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.164_165GG>AA; p.R55Q; 23:153445266-153445267

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.254T>C; p.L85P; 23:153445177-153445177

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.289G>A; p.V97M; 23:153445142-153445142

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.289G>A; p.V97M; 23:153445142-153445142

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.289G>A; p.V97M; 23:153445142-153445142

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

')