Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

115761

Name

ARL11

Synonymous

ADP-ribosylation factor-like 11;ARL11;ADP-ribosylation factor-like 11

Definition

ADP-ribosylation factor-like protein 11|ADP-ribosylation factor-like tumor suppressor protein 1

Position

13q14.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.16.

The copy number variations for various cancers

Top

There is no record for ARL11

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.80C>T; p.T27M; 13:49630527-49630527

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.80C>T; p.T27M; 13:49630527-49630527

 large_intestine; colonNSSubstitution - Missense

c.32C>T; p.A11V; 13:49630479-49630479

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.192_193insG; p.Q67fs*27; 13:49630639-49630640

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.216C>A; p.A72A; 13:49630663-49630663

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.343G>A; p.V115I; 13:49630790-49630790

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.343G>A; p.V115I; 13:49630790-49630790

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.226G>A; p.D76N; 13:49630673-49630673

 breastcarcinomaSubstitution - Missense

c.198G>A; p.G66G; 13:49630645-49630645

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.544C>T; p.Q182*; 13:49630991-49630991

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.284G>A; p.R95H; 13:49630731-49630731

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.284G>A; p.R95H; 13:49630731-49630731

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.388C>G; p.L130V; 13:49630835-49630835

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.181C>A; p.L61I; 13:49630628-49630628

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.262C>A; p.L88M; 13:49630709-49630709

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.262C>A; p.L88M; 13:49630709-49630709

 large_intestine; coloncarcinomaSubstitution - Missense

c.262C>A; p.L88M; 13:49630709-49630709

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.299C>T; p.A100V; 13:49630746-49630746

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.526C>T; p.R176C; 13:49630973-49630973

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.510G>A; p.W170*; 13:49630957-49630957

 NSmalignant_melanomaSubstitution - Nonsense

c.510G>A; p.W170*; 13:49630957-49630957

 NSmalignant_melanomaSubstitution - Nonsense

c.187G>A; p.D63N; 13:49630634-49630634

 skinmalignant_melanomaSubstitution - Missense

c.201G>T; p.Q67H; 13:49630648-49630648

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.46G>T; p.V16L; 13:49630493-49630493

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.190G>A; p.V64I; 13:49630637-49630637

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.265G>A; p.D89N; 13:49630712-49630712

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.297G>A; p.S99S; 13:49630744-49630744

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.297G>A; p.S99S; 13:49630744-49630744

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.297G>A; p.S99S; 13:49630744-49630744

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.193delG; p.Q67fs*41; 13:49630640-49630640

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.392C>T; p.P131L; 13:49630839-49630839

 thyroidother; neoplasmSubstitution - Missense

c.249C>T; p.I83I; 13:49630696-49630696

 skinmalignant_melanomaSubstitution - coding silent

c.33G>A; p.A11A; 13:49630480-49630480

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.530G>A; p.S177N; 13:49630977-49630977

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.258C>T; p.Y86Y; 13:49630705-49630705

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.253G>A; p.V85M; 13:49630700-49630700

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.40C>A; p.Q14K; 13:49630487-49630487

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.290C>T; p.P97L; 13:49630737-49630737

 skinmalignant_melanomaSubstitution - Missense

c.454C>T; p.R152W; 13:49630901-49630901

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.369G>A; p.K123K; 13:49630816-49630816

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.369G>A; p.K123K; 13:49630816-49630816

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.50T>C; p.M17T; 13:49630497-49630497

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.490G>A; p.E164K; 13:49630937-49630937

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.252C>A; p.L84L; 13:49630699-49630699

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.324C>T; p.N108N; 13:49630771-49630771

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.325G>A; p.D109N; 13:49630772-49630772

 skinmalignant_melanomaSubstitution - Missense

c.325G>A; p.D109N; 13:49630772-49630772

 skinmalignant_melanomaSubstitution - Missense

c.68C>T; p.A23V; 13:49630515-49630515

 breastcarcinomaSubstitution - Missense

c.446G>A; p.W149*; 13:49630893-49630893

 thyroidother; neoplasmSubstitution - Nonsense

c.177G>A; p.L59L; 13:49630624-49630624

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

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